Ultrastructural Changes in the Placental Membrane in Pregnancies Associated with Diabetes

Placenta is the most accurate record of the infant prenatal experience. If the placenta is examined minutely after delivery, it provides much insight into the prenatal health of the baby and the mother. The weight of placenta is higher in diabetic pregnancy in comparison to the normal pregnancy. To...

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Autores principales:	Verma,Ranjana, Mishra,S, Kaul,Jagat Mohini
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2011
Materias:	Gestational diabetes mellitus Transmission electron Microscopy Placental membrane
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400056
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spelling	oai:scielo:S0717-950220110004000562012-07-30Ultrastructural Changes in the Placental Membrane in Pregnancies Associated with DiabetesVerma,RanjanaMishra,SKaul,Jagat Mohini Gestational diabetes mellitus Transmission electron Microscopy Placental membrane Placenta is the most accurate record of the infant prenatal experience. If the placenta is examined minutely after delivery, it provides much insight into the prenatal health of the baby and the mother. The weight of placenta is higher in diabetic pregnancy in comparison to the normal pregnancy. To study the cellular changes that might contribute to more weight of placenta in diabetic pregnancies, light microscopic and electron microscopic analysis was performed. Twenty singleton pregnancies complicated with Gestational diabetes mellitus (12 controlled on diet, 8 controlled on insulin) were selected and compared to control group. Tissue sections were processed and analyzed. The placenta of diabetic pregnancies showed no abnormality on gross observation but light microscopic examination revealed, lesions like syncytial knots, fibrinoid necrosis, villous edema, villous fibrosis and capillary proliferation. Transmission electron microscopic examination (TEM) showed changes in almost all the layers of the placental membrane i.e. synctiotrophoblast, cytotrophoblast, trophoblastic basement membrane and fetal capillaries. These changes were observed in the placenta of both groups of patients whether blood sugar level was controlled by diet or insulin, but to different degree. It indicates that control of hyperglycemia only partially prevents the development of placental abnormalities which must be due to some other constituent factor of diabetic state.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.29 n.4 20112011-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400056en10.4067/S0717-95022011000400056
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Gestational diabetes mellitus Transmission electron Microscopy Placental membrane
spellingShingle	Gestational diabetes mellitus Transmission electron Microscopy Placental membrane Verma,Ranjana Mishra,S Kaul,Jagat Mohini Ultrastructural Changes in the Placental Membrane in Pregnancies Associated with Diabetes
description	Placenta is the most accurate record of the infant prenatal experience. If the placenta is examined minutely after delivery, it provides much insight into the prenatal health of the baby and the mother. The weight of placenta is higher in diabetic pregnancy in comparison to the normal pregnancy. To study the cellular changes that might contribute to more weight of placenta in diabetic pregnancies, light microscopic and electron microscopic analysis was performed. Twenty singleton pregnancies complicated with Gestational diabetes mellitus (12 controlled on diet, 8 controlled on insulin) were selected and compared to control group. Tissue sections were processed and analyzed. The placenta of diabetic pregnancies showed no abnormality on gross observation but light microscopic examination revealed, lesions like syncytial knots, fibrinoid necrosis, villous edema, villous fibrosis and capillary proliferation. Transmission electron microscopic examination (TEM) showed changes in almost all the layers of the placental membrane i.e. synctiotrophoblast, cytotrophoblast, trophoblastic basement membrane and fetal capillaries. These changes were observed in the placenta of both groups of patients whether blood sugar level was controlled by diet or insulin, but to different degree. It indicates that control of hyperglycemia only partially prevents the development of placental abnormalities which must be due to some other constituent factor of diabetic state.
author	Verma,Ranjana Mishra,S Kaul,Jagat Mohini
author_facet	Verma,Ranjana Mishra,S Kaul,Jagat Mohini
author_sort	Verma,Ranjana
title	Ultrastructural Changes in the Placental Membrane in Pregnancies Associated with Diabetes
title_short	Ultrastructural Changes in the Placental Membrane in Pregnancies Associated with Diabetes
title_full	Ultrastructural Changes in the Placental Membrane in Pregnancies Associated with Diabetes
title_fullStr	Ultrastructural Changes in the Placental Membrane in Pregnancies Associated with Diabetes
title_full_unstemmed	Ultrastructural Changes in the Placental Membrane in Pregnancies Associated with Diabetes
title_sort	ultrastructural changes in the placental membrane in pregnancies associated with diabetes
publisher	Sociedad Chilena de Anatomía
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400056
work_keys_str_mv	AT vermaranjana ultrastructuralchangesintheplacentalmembraneinpregnanciesassociatedwithdiabetes AT mishras ultrastructuralchangesintheplacentalmembraneinpregnanciesassociatedwithdiabetes AT kauljagatmohini ultrastructuralchangesintheplacentalmembraneinpregnanciesassociatedwithdiabetes
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Ultrastructural Changes in the Placental Membrane in Pregnancies Associated with Diabetes

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