Pure Micropapillary Rectal Carcinoma with CK7 and CK20 Coexpression and Loss of CDX2 Reactivity

The micropapillary carcinoma is regarded as an aggressive variant of adenocarcinoma in any location. Histologically is characterized by papillary cell clusters surrounded by clear spaces. The reported proportion of micropapillary carcinoma component to the entire tumor ranged from 5 to 80% and no pu...

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Autor principal:	Lino-Silva,Leonardo Saúl
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2012
Materias:	Micropapillary carcinoma Adenocarcinoma CK7 CK20 CDX2 Colorectal cancer
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000100004
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spelling	oai:scielo:S0717-950220120001000042012-06-08Pure Micropapillary Rectal Carcinoma with CK7 and CK20 Coexpression and Loss of CDX2 ReactivityLino-Silva,Leonardo Saúl Micropapillary carcinoma Adenocarcinoma CK7 CK20 CDX2 Colorectal cancer The micropapillary carcinoma is regarded as an aggressive variant of adenocarcinoma in any location. Histologically is characterized by papillary cell clusters surrounded by clear spaces. The reported proportion of micropapillary carcinoma component to the entire tumor ranged from 5 to 80% and no pure cases has been reported. There are near of 130 cases reported to date in colorectum. We experienced a patient with a pure micropapillary carcinoma showing coexpression of CK7, CK20, and absence of CDX2, which had an aggressive neoplasm with extense perineural, vascular and lymphatic invasion also extensive nodal metastasis. The presence of a micropapillary carcinoma in the colorectum seemed to be closely related with nodal metastasis, similar to the case for micropapillary carcinomas in other organs. Therefore, if a micropapillary component is identified in a tumor, particularly in a biopsy specimen, even if the pre-operative diagnosis is a pedunculated early colorectal cancer, should be carefully consider the extent of surgical resection due to the high potential for nodal metastasis.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.30 n.1 20122012-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000100004en10.4067/S0717-95022012000100004
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Micropapillary carcinoma Adenocarcinoma CK7 CK20 CDX2 Colorectal cancer
spellingShingle	Micropapillary carcinoma Adenocarcinoma CK7 CK20 CDX2 Colorectal cancer Lino-Silva,Leonardo Saúl Pure Micropapillary Rectal Carcinoma with CK7 and CK20 Coexpression and Loss of CDX2 Reactivity
description	The micropapillary carcinoma is regarded as an aggressive variant of adenocarcinoma in any location. Histologically is characterized by papillary cell clusters surrounded by clear spaces. The reported proportion of micropapillary carcinoma component to the entire tumor ranged from 5 to 80% and no pure cases has been reported. There are near of 130 cases reported to date in colorectum. We experienced a patient with a pure micropapillary carcinoma showing coexpression of CK7, CK20, and absence of CDX2, which had an aggressive neoplasm with extense perineural, vascular and lymphatic invasion also extensive nodal metastasis. The presence of a micropapillary carcinoma in the colorectum seemed to be closely related with nodal metastasis, similar to the case for micropapillary carcinomas in other organs. Therefore, if a micropapillary component is identified in a tumor, particularly in a biopsy specimen, even if the pre-operative diagnosis is a pedunculated early colorectal cancer, should be carefully consider the extent of surgical resection due to the high potential for nodal metastasis.
author	Lino-Silva,Leonardo Saúl
author_facet	Lino-Silva,Leonardo Saúl
author_sort	Lino-Silva,Leonardo Saúl
title	Pure Micropapillary Rectal Carcinoma with CK7 and CK20 Coexpression and Loss of CDX2 Reactivity
title_short	Pure Micropapillary Rectal Carcinoma with CK7 and CK20 Coexpression and Loss of CDX2 Reactivity
title_full	Pure Micropapillary Rectal Carcinoma with CK7 and CK20 Coexpression and Loss of CDX2 Reactivity
title_fullStr	Pure Micropapillary Rectal Carcinoma with CK7 and CK20 Coexpression and Loss of CDX2 Reactivity
title_full_unstemmed	Pure Micropapillary Rectal Carcinoma with CK7 and CK20 Coexpression and Loss of CDX2 Reactivity
title_sort	pure micropapillary rectal carcinoma with ck7 and ck20 coexpression and loss of cdx2 reactivity
publisher	Sociedad Chilena de Anatomía
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000100004
work_keys_str_mv	AT linosilvaleonardosaul puremicropapillaryrectalcarcinomawithck7andck20coexpressionandlossofcdx2reactivity
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Pure Micropapillary Rectal Carcinoma with CK7 and CK20 Coexpression and Loss of CDX2 Reactivity

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