Immunohistochemical Analysis of Human Homologue of Drosophila Patched (PTCH) in Dental Follicles of Impacted Third Molars

This study investigated the immunodetection of PTCH in epithelial components of dental follicles associated with impacted third molars without radiographic signs of pathosis. One hundred and five specimens of dental follicles associated with impacted third molars with incomplete rhizogenesis (betwee...

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Autores principales: Oliveira,David Moraes de, Silveira,Márcia Maria Ferreira da, Andrade,Emanuel Sávio de Souza, Sobral,Ana Paula Veras, Martins-Filho,Paulo Ricardo Saquete, Santos,Thiago de Santana, Oliveira,Patrícia Leimig Amorim de, Peixoto,Aline Carvalho, Santos,Jadson Alípio Santana de Souza, Piva,Marta Rabello
Lenguaje:English
Publicado: Sociedad Chilena de Anatomía 2012
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000100018
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spelling oai:scielo:S0717-950220120001000182012-06-08Immunohistochemical Analysis of Human Homologue of Drosophila Patched (PTCH) in Dental Follicles of Impacted Third MolarsOliveira,David Moraes deSilveira,Márcia Maria Ferreira daAndrade,Emanuel Sávio de SouzaSobral,Ana Paula VerasMartins-Filho,Paulo Ricardo SaqueteSantos,Thiago de SantanaOliveira,Patrícia Leimig Amorim dePeixoto,Aline CarvalhoSantos,Jadson Alípio Santana de SouzaPiva,Marta Rabello Immunohistochemistry Dental follicle Odontogenic epithelial PTCH This study investigated the immunodetection of PTCH in epithelial components of dental follicles associated with impacted third molars without radiographic signs of pathosis. One hundred and five specimens of dental follicles associated with impacted third molars with incomplete rhizogenesis (between Nolla's stage 6 and 9) were surgically removed from 56 patients. Epithelial cell proliferation was determined by using immunohistochemical labeling. Statistical analysis was performed using Fisher exact test and a level of significance of 5%. Of the 105 dental follicles collected, 3 were PTCH-positive. The specimens with squamous metaplasia and epithelial hyperplasia had higher rates of positivity for PTCH, as well as those with active remnants of odontogenic epithelium. This study suggests that the odontogenic cells of the dental follicle might be proliferating during the rhizogenesis, while the squamous metaplasia and hyperplasia of the epithelial lining and proliferative odontogenic epithelial rests show the differentiation potential of dental follicles.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.30 n.1 20122012-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000100018en10.4067/S0717-95022012000100018
institution Scielo Chile
collection Scielo Chile
language English
topic Immunohistochemistry
Dental follicle
Odontogenic epithelial
PTCH
spellingShingle Immunohistochemistry
Dental follicle
Odontogenic epithelial
PTCH
Oliveira,David Moraes de
Silveira,Márcia Maria Ferreira da
Andrade,Emanuel Sávio de Souza
Sobral,Ana Paula Veras
Martins-Filho,Paulo Ricardo Saquete
Santos,Thiago de Santana
Oliveira,Patrícia Leimig Amorim de
Peixoto,Aline Carvalho
Santos,Jadson Alípio Santana de Souza
Piva,Marta Rabello
Immunohistochemical Analysis of Human Homologue of Drosophila Patched (PTCH) in Dental Follicles of Impacted Third Molars
description This study investigated the immunodetection of PTCH in epithelial components of dental follicles associated with impacted third molars without radiographic signs of pathosis. One hundred and five specimens of dental follicles associated with impacted third molars with incomplete rhizogenesis (between Nolla's stage 6 and 9) were surgically removed from 56 patients. Epithelial cell proliferation was determined by using immunohistochemical labeling. Statistical analysis was performed using Fisher exact test and a level of significance of 5%. Of the 105 dental follicles collected, 3 were PTCH-positive. The specimens with squamous metaplasia and epithelial hyperplasia had higher rates of positivity for PTCH, as well as those with active remnants of odontogenic epithelium. This study suggests that the odontogenic cells of the dental follicle might be proliferating during the rhizogenesis, while the squamous metaplasia and hyperplasia of the epithelial lining and proliferative odontogenic epithelial rests show the differentiation potential of dental follicles.
author Oliveira,David Moraes de
Silveira,Márcia Maria Ferreira da
Andrade,Emanuel Sávio de Souza
Sobral,Ana Paula Veras
Martins-Filho,Paulo Ricardo Saquete
Santos,Thiago de Santana
Oliveira,Patrícia Leimig Amorim de
Peixoto,Aline Carvalho
Santos,Jadson Alípio Santana de Souza
Piva,Marta Rabello
author_facet Oliveira,David Moraes de
Silveira,Márcia Maria Ferreira da
Andrade,Emanuel Sávio de Souza
Sobral,Ana Paula Veras
Martins-Filho,Paulo Ricardo Saquete
Santos,Thiago de Santana
Oliveira,Patrícia Leimig Amorim de
Peixoto,Aline Carvalho
Santos,Jadson Alípio Santana de Souza
Piva,Marta Rabello
author_sort Oliveira,David Moraes de
title Immunohistochemical Analysis of Human Homologue of Drosophila Patched (PTCH) in Dental Follicles of Impacted Third Molars
title_short Immunohistochemical Analysis of Human Homologue of Drosophila Patched (PTCH) in Dental Follicles of Impacted Third Molars
title_full Immunohistochemical Analysis of Human Homologue of Drosophila Patched (PTCH) in Dental Follicles of Impacted Third Molars
title_fullStr Immunohistochemical Analysis of Human Homologue of Drosophila Patched (PTCH) in Dental Follicles of Impacted Third Molars
title_full_unstemmed Immunohistochemical Analysis of Human Homologue of Drosophila Patched (PTCH) in Dental Follicles of Impacted Third Molars
title_sort immunohistochemical analysis of human homologue of drosophila patched (ptch) in dental follicles of impacted third molars
publisher Sociedad Chilena de Anatomía
publishDate 2012
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000100018
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