Immunohistochemical Analysis of Human Homologue of Drosophila Patched (PTCH) in Dental Follicles of Impacted Third Molars
This study investigated the immunodetection of PTCH in epithelial components of dental follicles associated with impacted third molars without radiographic signs of pathosis. One hundred and five specimens of dental follicles associated with impacted third molars with incomplete rhizogenesis (betwee...
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Sociedad Chilena de Anatomía
2012
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oai:scielo:S0717-950220120001000182012-06-08Immunohistochemical Analysis of Human Homologue of Drosophila Patched (PTCH) in Dental Follicles of Impacted Third MolarsOliveira,David Moraes deSilveira,Márcia Maria Ferreira daAndrade,Emanuel Sávio de SouzaSobral,Ana Paula VerasMartins-Filho,Paulo Ricardo SaqueteSantos,Thiago de SantanaOliveira,Patrícia Leimig Amorim dePeixoto,Aline CarvalhoSantos,Jadson Alípio Santana de SouzaPiva,Marta Rabello Immunohistochemistry Dental follicle Odontogenic epithelial PTCH This study investigated the immunodetection of PTCH in epithelial components of dental follicles associated with impacted third molars without radiographic signs of pathosis. One hundred and five specimens of dental follicles associated with impacted third molars with incomplete rhizogenesis (between Nolla's stage 6 and 9) were surgically removed from 56 patients. Epithelial cell proliferation was determined by using immunohistochemical labeling. Statistical analysis was performed using Fisher exact test and a level of significance of 5%. Of the 105 dental follicles collected, 3 were PTCH-positive. The specimens with squamous metaplasia and epithelial hyperplasia had higher rates of positivity for PTCH, as well as those with active remnants of odontogenic epithelium. This study suggests that the odontogenic cells of the dental follicle might be proliferating during the rhizogenesis, while the squamous metaplasia and hyperplasia of the epithelial lining and proliferative odontogenic epithelial rests show the differentiation potential of dental follicles.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.30 n.1 20122012-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000100018en10.4067/S0717-95022012000100018 |
institution |
Scielo Chile |
collection |
Scielo Chile |
language |
English |
topic |
Immunohistochemistry Dental follicle Odontogenic epithelial PTCH |
spellingShingle |
Immunohistochemistry Dental follicle Odontogenic epithelial PTCH Oliveira,David Moraes de Silveira,Márcia Maria Ferreira da Andrade,Emanuel Sávio de Souza Sobral,Ana Paula Veras Martins-Filho,Paulo Ricardo Saquete Santos,Thiago de Santana Oliveira,Patrícia Leimig Amorim de Peixoto,Aline Carvalho Santos,Jadson Alípio Santana de Souza Piva,Marta Rabello Immunohistochemical Analysis of Human Homologue of Drosophila Patched (PTCH) in Dental Follicles of Impacted Third Molars |
description |
This study investigated the immunodetection of PTCH in epithelial components of dental follicles associated with impacted third molars without radiographic signs of pathosis. One hundred and five specimens of dental follicles associated with impacted third molars with incomplete rhizogenesis (between Nolla's stage 6 and 9) were surgically removed from 56 patients. Epithelial cell proliferation was determined by using immunohistochemical labeling. Statistical analysis was performed using Fisher exact test and a level of significance of 5%. Of the 105 dental follicles collected, 3 were PTCH-positive. The specimens with squamous metaplasia and epithelial hyperplasia had higher rates of positivity for PTCH, as well as those with active remnants of odontogenic epithelium. This study suggests that the odontogenic cells of the dental follicle might be proliferating during the rhizogenesis, while the squamous metaplasia and hyperplasia of the epithelial lining and proliferative odontogenic epithelial rests show the differentiation potential of dental follicles. |
author |
Oliveira,David Moraes de Silveira,Márcia Maria Ferreira da Andrade,Emanuel Sávio de Souza Sobral,Ana Paula Veras Martins-Filho,Paulo Ricardo Saquete Santos,Thiago de Santana Oliveira,Patrícia Leimig Amorim de Peixoto,Aline Carvalho Santos,Jadson Alípio Santana de Souza Piva,Marta Rabello |
author_facet |
Oliveira,David Moraes de Silveira,Márcia Maria Ferreira da Andrade,Emanuel Sávio de Souza Sobral,Ana Paula Veras Martins-Filho,Paulo Ricardo Saquete Santos,Thiago de Santana Oliveira,Patrícia Leimig Amorim de Peixoto,Aline Carvalho Santos,Jadson Alípio Santana de Souza Piva,Marta Rabello |
author_sort |
Oliveira,David Moraes de |
title |
Immunohistochemical Analysis of Human Homologue of Drosophila Patched (PTCH) in Dental Follicles of Impacted Third Molars |
title_short |
Immunohistochemical Analysis of Human Homologue of Drosophila Patched (PTCH) in Dental Follicles of Impacted Third Molars |
title_full |
Immunohistochemical Analysis of Human Homologue of Drosophila Patched (PTCH) in Dental Follicles of Impacted Third Molars |
title_fullStr |
Immunohistochemical Analysis of Human Homologue of Drosophila Patched (PTCH) in Dental Follicles of Impacted Third Molars |
title_full_unstemmed |
Immunohistochemical Analysis of Human Homologue of Drosophila Patched (PTCH) in Dental Follicles of Impacted Third Molars |
title_sort |
immunohistochemical analysis of human homologue of drosophila patched (ptch) in dental follicles of impacted third molars |
publisher |
Sociedad Chilena de Anatomía |
publishDate |
2012 |
url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000100018 |
work_keys_str_mv |
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1718444765217816576 |