Gamma Radiation-induced Impairment of Hippocampal Neurogenesis,Comparison of Single and Fractionated Dose Regimens

Radiation therapy of the brain is associated with many consequences, including cognitive disorders. Pathogenesis of radiation induced cognitive disorder is not clear, but reduction of neurogenesis in hippocampus may be an underlying reason. 24 adult male rats entered to study. Radiation absorbed dos...

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Autores principales:	Khoshbin khoshnazar,A. R, Jahanshahi,M, Azami,N. S
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2012
Materias:	Hippocampus Neurogenesis Radiation Fractionation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000100026
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spelling	oai:scielo:S0717-950220120001000262012-06-08Gamma Radiation-induced Impairment of Hippocampal Neurogenesis,Comparison of Single and Fractionated Dose RegimensKhoshbin khoshnazar,A. RJahanshahi,MAzami,N. S Hippocampus Neurogenesis Radiation Fractionation Radiation therapy of the brain is associated with many consequences, including cognitive disorders. Pathogenesis of radiation induced cognitive disorder is not clear, but reduction of neurogenesis in hippocampus may be an underlying reason. 24 adult male rats entered to study. Radiation absorbed dose to midbrain was 10 Gy, delivered by routine cobalt radiotherapy machine which its output was measured 115.24 cGy/min. The rats were divided in four groups of sixes, including groups of control, single fraction 10 Gy, fractionated 10 Gy and finally anaesthesia sham group. Number of pyramidal nerve cells was counted in two regions of hippocampus formation (CA1 and CA3). The radiation could reduce the number of cells in two regions of hippocampus significantly (p=0.000). It seems fractionated 10 Gy irradiation to more efficient than single fraction, while role of anaesthesia drug should be cautiously assessed. Moreover the rate of neurogenesis reduction was determined the same in these regions of hippocampus meaning the same radiosensitivity of cells.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.30 n.1 20122012-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000100026en10.4067/S0717-95022012000100026
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Hippocampus Neurogenesis Radiation Fractionation
spellingShingle	Hippocampus Neurogenesis Radiation Fractionation Khoshbin khoshnazar,A. R Jahanshahi,M Azami,N. S Gamma Radiation-induced Impairment of Hippocampal Neurogenesis,Comparison of Single and Fractionated Dose Regimens
description	Radiation therapy of the brain is associated with many consequences, including cognitive disorders. Pathogenesis of radiation induced cognitive disorder is not clear, but reduction of neurogenesis in hippocampus may be an underlying reason. 24 adult male rats entered to study. Radiation absorbed dose to midbrain was 10 Gy, delivered by routine cobalt radiotherapy machine which its output was measured 115.24 cGy/min. The rats were divided in four groups of sixes, including groups of control, single fraction 10 Gy, fractionated 10 Gy and finally anaesthesia sham group. Number of pyramidal nerve cells was counted in two regions of hippocampus formation (CA1 and CA3). The radiation could reduce the number of cells in two regions of hippocampus significantly (p=0.000). It seems fractionated 10 Gy irradiation to more efficient than single fraction, while role of anaesthesia drug should be cautiously assessed. Moreover the rate of neurogenesis reduction was determined the same in these regions of hippocampus meaning the same radiosensitivity of cells.
author	Khoshbin khoshnazar,A. R Jahanshahi,M Azami,N. S
author_facet	Khoshbin khoshnazar,A. R Jahanshahi,M Azami,N. S
author_sort	Khoshbin khoshnazar,A. R
title	Gamma Radiation-induced Impairment of Hippocampal Neurogenesis,Comparison of Single and Fractionated Dose Regimens
title_short	Gamma Radiation-induced Impairment of Hippocampal Neurogenesis,Comparison of Single and Fractionated Dose Regimens
title_full	Gamma Radiation-induced Impairment of Hippocampal Neurogenesis,Comparison of Single and Fractionated Dose Regimens
title_fullStr	Gamma Radiation-induced Impairment of Hippocampal Neurogenesis,Comparison of Single and Fractionated Dose Regimens
title_full_unstemmed	Gamma Radiation-induced Impairment of Hippocampal Neurogenesis,Comparison of Single and Fractionated Dose Regimens
title_sort	gamma radiation-induced impairment of hippocampal neurogenesis,comparison of single and fractionated dose regimens
publisher	Sociedad Chilena de Anatomía
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000100026
work_keys_str_mv	AT khoshbinkhoshnazarar gammaradiationinducedimpairmentofhippocampalneurogenesiscomparisonofsingleandfractionateddoseregimens AT jahanshahim gammaradiationinducedimpairmentofhippocampalneurogenesiscomparisonofsingleandfractionateddoseregimens AT azamins gammaradiationinducedimpairmentofhippocampalneurogenesiscomparisonofsingleandfractionateddoseregimens
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Gamma Radiation-induced Impairment of Hippocampal Neurogenesis,Comparison of Single and Fractionated Dose Regimens

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