Beneficial Effects of Exercise Training (Treadmill) on Body Mass and Skeletal Muscle Capillaries/Myocyte Ratio in C57BL/6 Mice Fed High-Fat Diet

C57BL/6 mice develop signals and symptoms comparable at least in part with the metabolic syndrome in humans. This study aimed to evaluate the beneficial effects of exercise training upon skeletal microcirculation in these mice. Animals were fed one of two diets during an eight week period: standard...

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Autores principales:	Motta,Victor Faria, Mandarim de Lacerda,Carlos Alberto
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2012
Materias:	Aerobic training Metabolic syndrome Lipid profile Skeletal muscle
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000100037
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spelling	oai:scielo:S0717-950220120001000372012-06-08Beneficial Effects of Exercise Training (Treadmill) on Body Mass and Skeletal Muscle Capillaries/Myocyte Ratio in C57BL/6 Mice Fed High-Fat DietMotta,Victor FariaMandarim de Lacerda,Carlos Alberto Aerobic training Metabolic syndrome Lipid profile Skeletal muscle C57BL/6 mice develop signals and symptoms comparable at least in part with the metabolic syndrome in humans. This study aimed to evaluate the beneficial effects of exercise training upon skeletal microcirculation in these mice. Animals were fed one of two diets during an eight week period: standard chow (SC) or very high-fat (HF). Afterwards, the exercise training protocol (treadmill) was established and mice divided into SC and HF sedentary (SC-Sed, HF-Sed) or exercised groups (SC-Ex, HF-Ex), respectively. HF/HF-Sed mice had the greatest body mass (plus 65% than SC-Sed; P<0.0001), and exercise reduced it by 23% (P<0.0001). The plasma insulin was higher in the HF-Sed than in the matched Ex (P<0.001). The ratio between capillaries/myocytes in HF-Ex group increased by 64% than in HF-Sed group (P<0.001) and increased by 80% in SC-Ex group than in SC-Sed group (P<0.001). In conclusion, exercise improved the lipid profile by reducing body mass gain, insulin resistance, ameliorating the skeletal muscle microcirculation.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.30 n.1 20122012-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000100037en10.4067/S0717-95022012000100037
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Aerobic training Metabolic syndrome Lipid profile Skeletal muscle
spellingShingle	Aerobic training Metabolic syndrome Lipid profile Skeletal muscle Motta,Victor Faria Mandarim de Lacerda,Carlos Alberto Beneficial Effects of Exercise Training (Treadmill) on Body Mass and Skeletal Muscle Capillaries/Myocyte Ratio in C57BL/6 Mice Fed High-Fat Diet
description	C57BL/6 mice develop signals and symptoms comparable at least in part with the metabolic syndrome in humans. This study aimed to evaluate the beneficial effects of exercise training upon skeletal microcirculation in these mice. Animals were fed one of two diets during an eight week period: standard chow (SC) or very high-fat (HF). Afterwards, the exercise training protocol (treadmill) was established and mice divided into SC and HF sedentary (SC-Sed, HF-Sed) or exercised groups (SC-Ex, HF-Ex), respectively. HF/HF-Sed mice had the greatest body mass (plus 65% than SC-Sed; P<0.0001), and exercise reduced it by 23% (P<0.0001). The plasma insulin was higher in the HF-Sed than in the matched Ex (P<0.001). The ratio between capillaries/myocytes in HF-Ex group increased by 64% than in HF-Sed group (P<0.001) and increased by 80% in SC-Ex group than in SC-Sed group (P<0.001). In conclusion, exercise improved the lipid profile by reducing body mass gain, insulin resistance, ameliorating the skeletal muscle microcirculation.
author	Motta,Victor Faria Mandarim de Lacerda,Carlos Alberto
author_facet	Motta,Victor Faria Mandarim de Lacerda,Carlos Alberto
author_sort	Motta,Victor Faria
title	Beneficial Effects of Exercise Training (Treadmill) on Body Mass and Skeletal Muscle Capillaries/Myocyte Ratio in C57BL/6 Mice Fed High-Fat Diet
title_short	Beneficial Effects of Exercise Training (Treadmill) on Body Mass and Skeletal Muscle Capillaries/Myocyte Ratio in C57BL/6 Mice Fed High-Fat Diet
title_full	Beneficial Effects of Exercise Training (Treadmill) on Body Mass and Skeletal Muscle Capillaries/Myocyte Ratio in C57BL/6 Mice Fed High-Fat Diet
title_fullStr	Beneficial Effects of Exercise Training (Treadmill) on Body Mass and Skeletal Muscle Capillaries/Myocyte Ratio in C57BL/6 Mice Fed High-Fat Diet
title_full_unstemmed	Beneficial Effects of Exercise Training (Treadmill) on Body Mass and Skeletal Muscle Capillaries/Myocyte Ratio in C57BL/6 Mice Fed High-Fat Diet
title_sort	beneficial effects of exercise training (treadmill) on body mass and skeletal muscle capillaries/myocyte ratio in c57bl/6 mice fed high-fat diet
publisher	Sociedad Chilena de Anatomía
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000100037
work_keys_str_mv	AT mottavictorfaria beneficialeffectsofexercisetrainingtreadmillonbodymassandskeletalmusclecapillariesmyocyteratioinc57bl6micefedhighfatdiet AT mandarimdelacerdacarlosalberto beneficialeffectsofexercisetrainingtreadmillonbodymassandskeletalmusclecapillariesmyocyteratioinc57bl6micefedhighfatdiet
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Beneficial Effects of Exercise Training (Treadmill) on Body Mass and Skeletal Muscle Capillaries/Myocyte Ratio in C57BL/6 Mice Fed High-Fat Diet

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