Bovine Bone Matrix Action Associated With Morphogenetic Protein in Bone Defects in Rats Submitted to Alcoholism

Extended excessive alcohol use causes changes in bone tissue, thus affecting osteogenesis. The objective of this study was to evaluate if demineralized bone matrix (Gen-ox®) associated with bone morphogenetic protein (Gen-pro®) changes bone neoformation in rats submitted to experimental alcoholism....

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Autores principales:	Buchaim,Rogério Leone, Andreo,Jesus Carlos, Rodrigues,Antonio de Castro, Buchaim,Daniela Vieira, Roque,Domingos Donizeti, Roque,José Sidney, Rosa Júnior,Geraldo Marco
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2012
Materias:	Bone repair Alcoholism Xenograft Bone morphogenetic proteins
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000100048
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spelling	oai:scielo:S0717-950220120001000482012-06-08Bovine Bone Matrix Action Associated With Morphogenetic Protein in Bone Defects in Rats Submitted to AlcoholismBuchaim,Rogério LeoneAndreo,Jesus CarlosRodrigues,Antonio de CastroBuchaim,Daniela VieiraRoque,Domingos DonizetiRoque,José SidneyRosa Júnior,Geraldo Marco Bone repair Alcoholism Xenograft Bone morphogenetic proteins Extended excessive alcohol use causes changes in bone tissue, thus affecting osteogenesis. The objective of this study was to evaluate if demineralized bone matrix (Gen-ox®) associated with bone morphogenetic protein (Gen-pro®) changes bone neoformation in rats submitted to experimental alcoholism. Forty male rats (Rattus norvegicus) were separated into 2 groups of 20 animals each: Group E1, which received ethyl alcohol at 25% and had the surgical cavity filled in only with blood clot; and Group E2, which received ethyl alcohol at 25% and had the surgical cavity filled in with demineralized bovine cortical bone associated with bone morphogenetic protein. The animals were submitted to a three-week period of gradual adaptation to alcohol, and then continued receiving alcohol at 25% for 90 days, when the surgical cavity was made. After the surgery, the animals continued consuming alcohol until reaching the sacrifice periods of 10, 20, 40, and 60 days, when the tibias were removed for histological processing. Results showed that surgical cavity repair and bone marrow reorganization occurred faster in Group E1 than in Group E2. At the end of the experiment, it was observed that animals in Group E2 had thick bony trabeculae surrounding the implanted material particles and a small area of connective tissue in the surface region. In conclusion, the implanted material did not accelerate bone neoformation, rather it served as a structure for osteogenesis.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.30 n.1 20122012-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000100048en10.4067/S0717-95022012000100048
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Bone repair Alcoholism Xenograft Bone morphogenetic proteins
spellingShingle	Bone repair Alcoholism Xenograft Bone morphogenetic proteins Buchaim,Rogério Leone Andreo,Jesus Carlos Rodrigues,Antonio de Castro Buchaim,Daniela Vieira Roque,Domingos Donizeti Roque,José Sidney Rosa Júnior,Geraldo Marco Bovine Bone Matrix Action Associated With Morphogenetic Protein in Bone Defects in Rats Submitted to Alcoholism
description	Extended excessive alcohol use causes changes in bone tissue, thus affecting osteogenesis. The objective of this study was to evaluate if demineralized bone matrix (Gen-ox®) associated with bone morphogenetic protein (Gen-pro®) changes bone neoformation in rats submitted to experimental alcoholism. Forty male rats (Rattus norvegicus) were separated into 2 groups of 20 animals each: Group E1, which received ethyl alcohol at 25% and had the surgical cavity filled in only with blood clot; and Group E2, which received ethyl alcohol at 25% and had the surgical cavity filled in with demineralized bovine cortical bone associated with bone morphogenetic protein. The animals were submitted to a three-week period of gradual adaptation to alcohol, and then continued receiving alcohol at 25% for 90 days, when the surgical cavity was made. After the surgery, the animals continued consuming alcohol until reaching the sacrifice periods of 10, 20, 40, and 60 days, when the tibias were removed for histological processing. Results showed that surgical cavity repair and bone marrow reorganization occurred faster in Group E1 than in Group E2. At the end of the experiment, it was observed that animals in Group E2 had thick bony trabeculae surrounding the implanted material particles and a small area of connective tissue in the surface region. In conclusion, the implanted material did not accelerate bone neoformation, rather it served as a structure for osteogenesis.
author	Buchaim,Rogério Leone Andreo,Jesus Carlos Rodrigues,Antonio de Castro Buchaim,Daniela Vieira Roque,Domingos Donizeti Roque,José Sidney Rosa Júnior,Geraldo Marco
author_facet	Buchaim,Rogério Leone Andreo,Jesus Carlos Rodrigues,Antonio de Castro Buchaim,Daniela Vieira Roque,Domingos Donizeti Roque,José Sidney Rosa Júnior,Geraldo Marco
author_sort	Buchaim,Rogério Leone
title	Bovine Bone Matrix Action Associated With Morphogenetic Protein in Bone Defects in Rats Submitted to Alcoholism
title_short	Bovine Bone Matrix Action Associated With Morphogenetic Protein in Bone Defects in Rats Submitted to Alcoholism
title_full	Bovine Bone Matrix Action Associated With Morphogenetic Protein in Bone Defects in Rats Submitted to Alcoholism
title_fullStr	Bovine Bone Matrix Action Associated With Morphogenetic Protein in Bone Defects in Rats Submitted to Alcoholism
title_full_unstemmed	Bovine Bone Matrix Action Associated With Morphogenetic Protein in Bone Defects in Rats Submitted to Alcoholism
title_sort	bovine bone matrix action associated with morphogenetic protein in bone defects in rats submitted to alcoholism
publisher	Sociedad Chilena de Anatomía
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000100048
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Bovine Bone Matrix Action Associated With Morphogenetic Protein in Bone Defects in Rats Submitted to Alcoholism

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