Effect of Scopolamine-based Amnesia on the Number of Astrocytes in the Rat's Hippocampus

As neuronastrocyte interactions play a crucial role in the adult brain, it is thought that astrocytes support learning and memory through specific mechanisms. In this study, the effect of scopolamine based amnesia on the number of astrocytes in rats' hippocampus was studied. Adult male albino...

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Autores principales:	Jahanshahi,M, Azami,N. S, Nickmahzar,E
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2012
Materias:	Scopolamine Amnesia Astrocyte Hippocampus Rat
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000200004
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spelling	oai:scielo:S0717-950220120002000042012-10-03Effect of Scopolamine-based Amnesia on the Number of Astrocytes in the Rat's HippocampusJahanshahi,MAzami,N. SNickmahzar,E Scopolamine Amnesia Astrocyte Hippocampus Rat As neuronastrocyte interactions play a crucial role in the adult brain, it is thought that astrocytes support learning and memory through specific mechanisms. In this study, the effect of scopolamine based amnesia on the number of astrocytes in rats' hippocampus was studied. Adult male albino Wistar rats were bilaterally cannulated into the CA1 region and animals received saline or different doses of scopolamine (0.5, 1 and 2 mg/ rat, intra - CA1), immediately after training. Then all the rats were sacrificed and coronal sections were taken from the dorsal hippocampal formation of the right cerebral hemispheres and stained with PTAH. The area densities of the astrocytes in dentate gyrus were measured and compared in the all groups (p < 0.05). Data showed that post-training scopolamine (0.5, 1 and 2 µg/rat, intra-CA1) dose-dependently reduced the step-through latency in the inhibitory avoidance task, showing scopolamine-induced amnesia. Also we found different response of astrocytes in different subfields of hippocampal formation. In dentate gyrus the number of astrocytes was increased, but in other areas scopolamine can decreased the density of astrocytes. We concluded that scopolamine can cause amnesia and this phenomenon can have an effect on astrocyte numbers in the rats hippocampal formation.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.30 n.2 20122012-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000200004en10.4067/S0717-95022012000200004
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Scopolamine Amnesia Astrocyte Hippocampus Rat
spellingShingle	Scopolamine Amnesia Astrocyte Hippocampus Rat Jahanshahi,M Azami,N. S Nickmahzar,E Effect of Scopolamine-based Amnesia on the Number of Astrocytes in the Rat's Hippocampus
description	As neuronastrocyte interactions play a crucial role in the adult brain, it is thought that astrocytes support learning and memory through specific mechanisms. In this study, the effect of scopolamine based amnesia on the number of astrocytes in rats' hippocampus was studied. Adult male albino Wistar rats were bilaterally cannulated into the CA1 region and animals received saline or different doses of scopolamine (0.5, 1 and 2 mg/ rat, intra - CA1), immediately after training. Then all the rats were sacrificed and coronal sections were taken from the dorsal hippocampal formation of the right cerebral hemispheres and stained with PTAH. The area densities of the astrocytes in dentate gyrus were measured and compared in the all groups (p < 0.05). Data showed that post-training scopolamine (0.5, 1 and 2 µg/rat, intra-CA1) dose-dependently reduced the step-through latency in the inhibitory avoidance task, showing scopolamine-induced amnesia. Also we found different response of astrocytes in different subfields of hippocampal formation. In dentate gyrus the number of astrocytes was increased, but in other areas scopolamine can decreased the density of astrocytes. We concluded that scopolamine can cause amnesia and this phenomenon can have an effect on astrocyte numbers in the rats hippocampal formation.
author	Jahanshahi,M Azami,N. S Nickmahzar,E
author_facet	Jahanshahi,M Azami,N. S Nickmahzar,E
author_sort	Jahanshahi,M
title	Effect of Scopolamine-based Amnesia on the Number of Astrocytes in the Rat's Hippocampus
title_short	Effect of Scopolamine-based Amnesia on the Number of Astrocytes in the Rat's Hippocampus
title_full	Effect of Scopolamine-based Amnesia on the Number of Astrocytes in the Rat's Hippocampus
title_fullStr	Effect of Scopolamine-based Amnesia on the Number of Astrocytes in the Rat's Hippocampus
title_full_unstemmed	Effect of Scopolamine-based Amnesia on the Number of Astrocytes in the Rat's Hippocampus
title_sort	effect of scopolamine-based amnesia on the number of astrocytes in the rat's hippocampus
publisher	Sociedad Chilena de Anatomía
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000200004
work_keys_str_mv	AT jahanshahim effectofscopolaminebasedamnesiaonthenumberofastrocytesintheratshippocampus AT azamins effectofscopolaminebasedamnesiaonthenumberofastrocytesintheratshippocampus AT nickmahzare effectofscopolaminebasedamnesiaonthenumberofastrocytesintheratshippocampus
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Effect of Scopolamine-based Amnesia on the Number of Astrocytes in the Rat's Hippocampus

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