Elastin Accumulation in Actinic Cheilitis with Different Degrees of Epithelial Dysplasia

The extracellular matrix (ECM) plays an important role in the regulation of biological events such as the development of cell migration, proliferation and differentiation. Chronic sun exposure causes changes present in the ECM of actinic cheilitis (AC), a premalignant lesion of the lower lip which h...

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Autores principales:	Araújo,Caliandra Pinto, Xavier,Flávia Caló de Aquino, Gurgel,Clarissa Araújo Silva, Ramos,Eduardo Antônio Gonçalves, Freitas,Valéria Souza, Schlaepfer-Sales,Caroline Brandi, Ramalho,Luciana Maria Pedreira, dos Santos,Jean Nunes
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2012
Materias:	Matrix extracellular Elastin Immunohistochemistry Actinic cheilitis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000200044
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id	oai:scielo:S0717-95022012000200044
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spelling	oai:scielo:S0717-950220120002000442012-10-03Elastin Accumulation in Actinic Cheilitis with Different Degrees of Epithelial DysplasiaAraújo,Caliandra PintoXavier,Flávia Caló de AquinoGurgel,Clarissa Araújo SilvaRamos,Eduardo Antônio GonçalvesFreitas,Valéria SouzaSchlaepfer-Sales,Caroline BrandiRamalho,Luciana Maria Pedreirados Santos,Jean Nunes Matrix extracellular Elastin Immunohistochemistry Actinic cheilitis The extracellular matrix (ECM) plays an important role in the regulation of biological events such as the development of cell migration, proliferation and differentiation. Chronic sun exposure causes changes present in the ECM of actinic cheilitis (AC), a premalignant lesion of the lower lip which helps to understand the carcinogenesis of the lip. This study aimed to investigate elastin, the main component of solar elastosis alternating current in an attempt to establish the relationship between this protein and ECM in epithelial dysplasia. Paraffin embedded tissue sections of the lesions of 35 cases of AC were analyzed by immunohistochemistry for elastin, and became the association with the degree of epithelial dysplasia and age. Highest scores of elastin (+3) was predominant in 45.7% of cases of AC, especially in cases of severe dysplasia (n = 3). When comparing the scores of elastin between the different grades of epithelial dysplasia showed no significant difference (P> 0.05, Kruskal-Wallis). This study was not able to demonstrate the influence of elastin on the severity of epithelial dysplasia in AC. Additional studies on other ECM proteins must be conducted in an attempt to better understand the mechanism of malignant progression of the AC.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.30 n.2 20122012-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000200044en10.4067/S0717-95022012000200044
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Matrix extracellular Elastin Immunohistochemistry Actinic cheilitis
spellingShingle	Matrix extracellular Elastin Immunohistochemistry Actinic cheilitis Araújo,Caliandra Pinto Xavier,Flávia Caló de Aquino Gurgel,Clarissa Araújo Silva Ramos,Eduardo Antônio Gonçalves Freitas,Valéria Souza Schlaepfer-Sales,Caroline Brandi Ramalho,Luciana Maria Pedreira dos Santos,Jean Nunes Elastin Accumulation in Actinic Cheilitis with Different Degrees of Epithelial Dysplasia
description	The extracellular matrix (ECM) plays an important role in the regulation of biological events such as the development of cell migration, proliferation and differentiation. Chronic sun exposure causes changes present in the ECM of actinic cheilitis (AC), a premalignant lesion of the lower lip which helps to understand the carcinogenesis of the lip. This study aimed to investigate elastin, the main component of solar elastosis alternating current in an attempt to establish the relationship between this protein and ECM in epithelial dysplasia. Paraffin embedded tissue sections of the lesions of 35 cases of AC were analyzed by immunohistochemistry for elastin, and became the association with the degree of epithelial dysplasia and age. Highest scores of elastin (+3) was predominant in 45.7% of cases of AC, especially in cases of severe dysplasia (n = 3). When comparing the scores of elastin between the different grades of epithelial dysplasia showed no significant difference (P> 0.05, Kruskal-Wallis). This study was not able to demonstrate the influence of elastin on the severity of epithelial dysplasia in AC. Additional studies on other ECM proteins must be conducted in an attempt to better understand the mechanism of malignant progression of the AC.
author	Araújo,Caliandra Pinto Xavier,Flávia Caló de Aquino Gurgel,Clarissa Araújo Silva Ramos,Eduardo Antônio Gonçalves Freitas,Valéria Souza Schlaepfer-Sales,Caroline Brandi Ramalho,Luciana Maria Pedreira dos Santos,Jean Nunes
author_facet	Araújo,Caliandra Pinto Xavier,Flávia Caló de Aquino Gurgel,Clarissa Araújo Silva Ramos,Eduardo Antônio Gonçalves Freitas,Valéria Souza Schlaepfer-Sales,Caroline Brandi Ramalho,Luciana Maria Pedreira dos Santos,Jean Nunes
author_sort	Araújo,Caliandra Pinto
title	Elastin Accumulation in Actinic Cheilitis with Different Degrees of Epithelial Dysplasia
title_short	Elastin Accumulation in Actinic Cheilitis with Different Degrees of Epithelial Dysplasia
title_full	Elastin Accumulation in Actinic Cheilitis with Different Degrees of Epithelial Dysplasia
title_fullStr	Elastin Accumulation in Actinic Cheilitis with Different Degrees of Epithelial Dysplasia
title_full_unstemmed	Elastin Accumulation in Actinic Cheilitis with Different Degrees of Epithelial Dysplasia
title_sort	elastin accumulation in actinic cheilitis with different degrees of epithelial dysplasia
publisher	Sociedad Chilena de Anatomía
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000200044
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_version_	1718444782262419456

Elastin Accumulation in Actinic Cheilitis with Different Degrees of Epithelial Dysplasia

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