Effect of Five Single Nucleotide Polymorphisms of ABCG5 and ABCG8 Genes on Ezetimibe Lipid-Lowering Response

In this study we evaluated the possible association between five single nucleotide polymorphisms in ABCG5 (rs6720173) and ABCG8 (rs11887534, rs4148211, rs4148217 and rs6544718) genes and ezetimibe response in Chilean hypercholesterolemic subjects. A total of 60 non-related hypercholesterolemic subje...

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Autores principales:	Caamaño,José M, Saavedra,Nicolás, Zambrano,Tomás, Lanas,Fernando, Salazar,Luis A
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2012
Materias:	Ezetimibe Cholesterol ABCG5/G8 Polymorphisms
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000200055
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spelling	oai:scielo:S0717-950220120002000552012-10-03Effect of Five Single Nucleotide Polymorphisms of ABCG5 and ABCG8 Genes on Ezetimibe Lipid-Lowering ResponseCaamaño,José MSaavedra,NicolásZambrano,TomásLanas,FernandoSalazar,Luis A Ezetimibe Cholesterol ABCG5/G8 Polymorphisms In this study we evaluated the possible association between five single nucleotide polymorphisms in ABCG5 (rs6720173) and ABCG8 (rs11887534, rs4148211, rs4148217 and rs6544718) genes and ezetimibe response in Chilean hypercholesterolemic subjects. A total of 60 non-related hypercholesterolemic subjects, aged 18 to 65 years old were included in this study. These subjects were treated with ezetimibe (10mg/day) during one month. The ABCG5 and ABCG8 genotypes were assessed by PCR-RFLP. The genotype distribution of the ABCG5/ABCG8 polymorphisms was in Hardy-Weinberg equilibrium. Our results showed that the investigated polymorphisms were not associated with the response to ezetimibe. Nevertheless, the T allele of rs6544718 polymorphism was related to higher baseline levels of LDL-cholesterol (p<0.001). In addition, the G allele for the rs4148211 polymorphism was associated with greater baseline concentrations of triglycerides (P=0.019). This allele was also associated with lower concentrations of HDL-cholesterol (P=0.027), after ezetimibe treatment. Our results suggest that the studied polymorphisms do not affect the therapeutic response to ezetimibe in the evaluated subjects.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.30 n.2 20122012-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000200055en10.4067/S0717-95022012000200055
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Ezetimibe Cholesterol ABCG5/G8 Polymorphisms
spellingShingle	Ezetimibe Cholesterol ABCG5/G8 Polymorphisms Caamaño,José M Saavedra,Nicolás Zambrano,Tomás Lanas,Fernando Salazar,Luis A Effect of Five Single Nucleotide Polymorphisms of ABCG5 and ABCG8 Genes on Ezetimibe Lipid-Lowering Response
description	In this study we evaluated the possible association between five single nucleotide polymorphisms in ABCG5 (rs6720173) and ABCG8 (rs11887534, rs4148211, rs4148217 and rs6544718) genes and ezetimibe response in Chilean hypercholesterolemic subjects. A total of 60 non-related hypercholesterolemic subjects, aged 18 to 65 years old were included in this study. These subjects were treated with ezetimibe (10mg/day) during one month. The ABCG5 and ABCG8 genotypes were assessed by PCR-RFLP. The genotype distribution of the ABCG5/ABCG8 polymorphisms was in Hardy-Weinberg equilibrium. Our results showed that the investigated polymorphisms were not associated with the response to ezetimibe. Nevertheless, the T allele of rs6544718 polymorphism was related to higher baseline levels of LDL-cholesterol (p<0.001). In addition, the G allele for the rs4148211 polymorphism was associated with greater baseline concentrations of triglycerides (P=0.019). This allele was also associated with lower concentrations of HDL-cholesterol (P=0.027), after ezetimibe treatment. Our results suggest that the studied polymorphisms do not affect the therapeutic response to ezetimibe in the evaluated subjects.
author	Caamaño,José M Saavedra,Nicolás Zambrano,Tomás Lanas,Fernando Salazar,Luis A
author_facet	Caamaño,José M Saavedra,Nicolás Zambrano,Tomás Lanas,Fernando Salazar,Luis A
author_sort	Caamaño,José M
title	Effect of Five Single Nucleotide Polymorphisms of ABCG5 and ABCG8 Genes on Ezetimibe Lipid-Lowering Response
title_short	Effect of Five Single Nucleotide Polymorphisms of ABCG5 and ABCG8 Genes on Ezetimibe Lipid-Lowering Response
title_full	Effect of Five Single Nucleotide Polymorphisms of ABCG5 and ABCG8 Genes on Ezetimibe Lipid-Lowering Response
title_fullStr	Effect of Five Single Nucleotide Polymorphisms of ABCG5 and ABCG8 Genes on Ezetimibe Lipid-Lowering Response
title_full_unstemmed	Effect of Five Single Nucleotide Polymorphisms of ABCG5 and ABCG8 Genes on Ezetimibe Lipid-Lowering Response
title_sort	effect of five single nucleotide polymorphisms of abcg5 and abcg8 genes on ezetimibe lipid-lowering response
publisher	Sociedad Chilena de Anatomía
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000200055
work_keys_str_mv	AT caamanojosem effectoffivesinglenucleotidepolymorphismsofabcg5andabcg8genesonezetimibelipidloweringresponse AT saavedranicolas effectoffivesinglenucleotidepolymorphismsofabcg5andabcg8genesonezetimibelipidloweringresponse AT zambranotomas effectoffivesinglenucleotidepolymorphismsofabcg5andabcg8genesonezetimibelipidloweringresponse AT lanasfernando effectoffivesinglenucleotidepolymorphismsofabcg5andabcg8genesonezetimibelipidloweringresponse AT salazarluisa effectoffivesinglenucleotidepolymorphismsofabcg5andabcg8genesonezetimibelipidloweringresponse
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Effect of Five Single Nucleotide Polymorphisms of ABCG5 and ABCG8 Genes on Ezetimibe Lipid-Lowering Response

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