Cytomorphology of Circulating Tumor Cells and Cell Clusters in Chilean Patients with Colo-Rectal Cancer

The aim of this study was to determine the cytomorphological characteristics of circulating tumor cells (CTCS) in patients with colo-rectal cancer and compare them with the primary tumor and metastasis. CTCS were obtained from blood using differential gel centrifugation and detected using standard i...

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Autores principales:	Murray,Nigel P, Vidal Albarran,R-C, Pérez O,Guillermo, Ruiz M,Amparo, Porcell E,José, Castillo A,Ana María
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2012
Materias:	Circulating tumor cells Colo-rectal cancer Immunocytochemistry
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000300011
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spelling	oai:scielo:S0717-950220120003000112013-02-20Cytomorphology of Circulating Tumor Cells and Cell Clusters in Chilean Patients with Colo-Rectal CancerMurray,Nigel PVidal Albarran,R-CPérez O,GuillermoRuiz M,AmparoPorcell E,JoséCastillo A,Ana María Circulating tumor cells Colo-rectal cancer Immunocytochemistry The aim of this study was to determine the cytomorphological characteristics of circulating tumor cells (CTCS) in patients with colo-rectal cancer and compare them with the primary tumor and metastasis. CTCS were obtained from blood using differential gel centrifugation and detected using standard immunocytochemistry using anti-CEA. Primary CTCs were defined as those detected before surgery and secondary CTCs those detected after. Surgical specimens of the primary tumor and metastasis were evaluated using standard histological methods with hematoxillin and eosin. CTCs both primary and secondary retained the cytomorphological characteristics of the primary tumor, showing marked intra-patient pleomorphism. There were no differences between primary and secondary CTCs in their cytomorphological features. CTCs from patients with signet ring tumors showed the presence of intracellular mucin deposits. Groups of 3 or more CTCs were only seen in patients with metastasis, whereas duplets of CTcs were seen in patients with metastatic and non-metastatic colo-rectal cancer. This study provides an initial analysis of the cytomorphological features of CTCs, providing a foundation for further investigation into the significance and metastatic potential of CTCs.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.30 n.3 20122012-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000300011en10.4067/S0717-95022012000300011
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Circulating tumor cells Colo-rectal cancer Immunocytochemistry
spellingShingle	Circulating tumor cells Colo-rectal cancer Immunocytochemistry Murray,Nigel P Vidal Albarran,R-C Pérez O,Guillermo Ruiz M,Amparo Porcell E,José Castillo A,Ana María Cytomorphology of Circulating Tumor Cells and Cell Clusters in Chilean Patients with Colo-Rectal Cancer
description	The aim of this study was to determine the cytomorphological characteristics of circulating tumor cells (CTCS) in patients with colo-rectal cancer and compare them with the primary tumor and metastasis. CTCS were obtained from blood using differential gel centrifugation and detected using standard immunocytochemistry using anti-CEA. Primary CTCs were defined as those detected before surgery and secondary CTCs those detected after. Surgical specimens of the primary tumor and metastasis were evaluated using standard histological methods with hematoxillin and eosin. CTCs both primary and secondary retained the cytomorphological characteristics of the primary tumor, showing marked intra-patient pleomorphism. There were no differences between primary and secondary CTCs in their cytomorphological features. CTCs from patients with signet ring tumors showed the presence of intracellular mucin deposits. Groups of 3 or more CTCs were only seen in patients with metastasis, whereas duplets of CTcs were seen in patients with metastatic and non-metastatic colo-rectal cancer. This study provides an initial analysis of the cytomorphological features of CTCs, providing a foundation for further investigation into the significance and metastatic potential of CTCs.
author	Murray,Nigel P Vidal Albarran,R-C Pérez O,Guillermo Ruiz M,Amparo Porcell E,José Castillo A,Ana María
author_facet	Murray,Nigel P Vidal Albarran,R-C Pérez O,Guillermo Ruiz M,Amparo Porcell E,José Castillo A,Ana María
author_sort	Murray,Nigel P
title	Cytomorphology of Circulating Tumor Cells and Cell Clusters in Chilean Patients with Colo-Rectal Cancer
title_short	Cytomorphology of Circulating Tumor Cells and Cell Clusters in Chilean Patients with Colo-Rectal Cancer
title_full	Cytomorphology of Circulating Tumor Cells and Cell Clusters in Chilean Patients with Colo-Rectal Cancer
title_fullStr	Cytomorphology of Circulating Tumor Cells and Cell Clusters in Chilean Patients with Colo-Rectal Cancer
title_full_unstemmed	Cytomorphology of Circulating Tumor Cells and Cell Clusters in Chilean Patients with Colo-Rectal Cancer
title_sort	cytomorphology of circulating tumor cells and cell clusters in chilean patients with colo-rectal cancer
publisher	Sociedad Chilena de Anatomía
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000300011
work_keys_str_mv	AT murraynigelp cytomorphologyofcirculatingtumorcellsandcellclustersinchileanpatientswithcolorectalcancer AT vidalalbarranrc cytomorphologyofcirculatingtumorcellsandcellclustersinchileanpatientswithcolorectalcancer AT perezoguillermo cytomorphologyofcirculatingtumorcellsandcellclustersinchileanpatientswithcolorectalcancer AT ruizmamparo cytomorphologyofcirculatingtumorcellsandcellclustersinchileanpatientswithcolorectalcancer AT porcellejose cytomorphologyofcirculatingtumorcellsandcellclustersinchileanpatientswithcolorectalcancer AT castilloaanamaria cytomorphologyofcirculatingtumorcellsandcellclustersinchileanpatientswithcolorectalcancer
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Cytomorphology of Circulating Tumor Cells and Cell Clusters in Chilean Patients with Colo-Rectal Cancer

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