Effects of Chronic Administration of Efavirenz on the Chromatophilic Substance of the Intracranial Auditory Relay Centres of Adult Wistar Rats

The effects of chronic administration of efavirenz commonly used as part of highly active antiretroviral therapy (HAART) for the treatment of Human Immunodeficiency Virus (HIV) type-1 therapy on the chromatophilic substance of the intracranial auditory relay centre namely the inferior colliculus and...

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Autores principales:	Adjene,J. O, Igbigbi,P. S
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2012
Materias:	Efavirenz Chromatophilic substance Inferior colliculus Medial Geniculate body Wistar rats
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000300037
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spelling	oai:scielo:S0717-950220120003000372013-02-20Effects of Chronic Administration of Efavirenz on the Chromatophilic Substance of the Intracranial Auditory Relay Centres of Adult Wistar RatsAdjene,J. OIgbigbi,P. S Efavirenz Chromatophilic substance Inferior colliculus Medial Geniculate body Wistar rats The effects of chronic administration of efavirenz commonly used as part of highly active antiretroviral therapy (HAART) for the treatment of Human Immunodeficiency Virus (HIV) type-1 therapy on the chromatophilic substance of the intracranial auditory relay centre namely the inferior colliculus and medial geniculate body of adult wistar rats were carefully studied. The rats of both sexes (n=20), with an average weight of 200g were randomly assigned into treatment (n=10) and control (n=10) groups. The rats in the treatment group received 600 mg/70kg body weight of efavirenz dissolved in distilled water daily for 30 days through the orogastric tube. The control group received equal volume of distilled water daily for 30 days through the same route. The rats were fed with grower's mash obtained from Edo Feeds and Flour Mill Limited, Ewu, Edo state, Nigeria and given water liberally. The rats were sacrificed by cervical dislocation method on the thirty-first day of the experiment. The inferior colliculus and medial geniculate body were carefully dissected out and quickly fixed in 10% formal saline for histological study. The histological findings indicated that the treated sections of the inferior colliculus and medial geniculate body showed that the chromatophilics substances were less intensely stained as compared to the control. The parenchyme was vacuolated and with evidence of hypertrophy and more spaces between the axonal mesh around the sparsely distributed neurons as compared to the control group. The treated section of the inferior colliculus showed neurons with faintly stained chromatophilics substances in large, medium and small sized neurons while that of the medial geniculate body showed less intense and enlarge chromatophilics substances with some vacuolations. Chronic administration of efavirenz may therefore have an adverse effect on the chromatophilics substances of the inferior colliculus and medial geniculate body of adult wistar rats. It is recommended that further studies aimed at corroborating these observations be carried out.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.30 n.3 20122012-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000300037en10.4067/S0717-95022012000300037
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Efavirenz Chromatophilic substance Inferior colliculus Medial Geniculate body Wistar rats
spellingShingle	Efavirenz Chromatophilic substance Inferior colliculus Medial Geniculate body Wistar rats Adjene,J. O Igbigbi,P. S Effects of Chronic Administration of Efavirenz on the Chromatophilic Substance of the Intracranial Auditory Relay Centres of Adult Wistar Rats
description	The effects of chronic administration of efavirenz commonly used as part of highly active antiretroviral therapy (HAART) for the treatment of Human Immunodeficiency Virus (HIV) type-1 therapy on the chromatophilic substance of the intracranial auditory relay centre namely the inferior colliculus and medial geniculate body of adult wistar rats were carefully studied. The rats of both sexes (n=20), with an average weight of 200g were randomly assigned into treatment (n=10) and control (n=10) groups. The rats in the treatment group received 600 mg/70kg body weight of efavirenz dissolved in distilled water daily for 30 days through the orogastric tube. The control group received equal volume of distilled water daily for 30 days through the same route. The rats were fed with grower's mash obtained from Edo Feeds and Flour Mill Limited, Ewu, Edo state, Nigeria and given water liberally. The rats were sacrificed by cervical dislocation method on the thirty-first day of the experiment. The inferior colliculus and medial geniculate body were carefully dissected out and quickly fixed in 10% formal saline for histological study. The histological findings indicated that the treated sections of the inferior colliculus and medial geniculate body showed that the chromatophilics substances were less intensely stained as compared to the control. The parenchyme was vacuolated and with evidence of hypertrophy and more spaces between the axonal mesh around the sparsely distributed neurons as compared to the control group. The treated section of the inferior colliculus showed neurons with faintly stained chromatophilics substances in large, medium and small sized neurons while that of the medial geniculate body showed less intense and enlarge chromatophilics substances with some vacuolations. Chronic administration of efavirenz may therefore have an adverse effect on the chromatophilics substances of the inferior colliculus and medial geniculate body of adult wistar rats. It is recommended that further studies aimed at corroborating these observations be carried out.
author	Adjene,J. O Igbigbi,P. S
author_facet	Adjene,J. O Igbigbi,P. S
author_sort	Adjene,J. O
title	Effects of Chronic Administration of Efavirenz on the Chromatophilic Substance of the Intracranial Auditory Relay Centres of Adult Wistar Rats
title_short	Effects of Chronic Administration of Efavirenz on the Chromatophilic Substance of the Intracranial Auditory Relay Centres of Adult Wistar Rats
title_full	Effects of Chronic Administration of Efavirenz on the Chromatophilic Substance of the Intracranial Auditory Relay Centres of Adult Wistar Rats
title_fullStr	Effects of Chronic Administration of Efavirenz on the Chromatophilic Substance of the Intracranial Auditory Relay Centres of Adult Wistar Rats
title_full_unstemmed	Effects of Chronic Administration of Efavirenz on the Chromatophilic Substance of the Intracranial Auditory Relay Centres of Adult Wistar Rats
title_sort	effects of chronic administration of efavirenz on the chromatophilic substance of the intracranial auditory relay centres of adult wistar rats
publisher	Sociedad Chilena de Anatomía
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000300037
work_keys_str_mv	AT adjenejo effectsofchronicadministrationofefavirenzonthechromatophilicsubstanceoftheintracranialauditoryrelaycentresofadultwistarrats AT igbigbips effectsofchronicadministrationofefavirenzonthechromatophilicsubstanceoftheintracranialauditoryrelaycentresofadultwistarrats
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Effects of Chronic Administration of Efavirenz on the Chromatophilic Substance of the Intracranial Auditory Relay Centres of Adult Wistar Rats

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