Prenatal Stress Caused by Movement Restriction Induces Changes in the Appendicular Osseous Development of CF-1 Mice Progeny

Prenatal stress has been associatedwith alterationsin weight andbody size, as well as disturbances inthe process ofdevelopingskeletalossification, occurringduring childbirth and the early stagesof life.However, theeffectevidence of prenatal stresson bone growthand development duringthe gestation per...

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Autores principales:	Lizana,Pablo, Henríquez,Ricardo, Muñoz,Pablo
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2012
Materias:	Prenatal Stress CF1 Mouse Alizarin red Appendicular Skeletal Morphometric Movement restriction
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000300059
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spelling	oai:scielo:S0717-950220120003000592013-02-20Prenatal Stress Caused by Movement Restriction Induces Changes in the Appendicular Osseous Development of CF-1 Mice ProgenyLizana,PabloHenríquez,RicardoMuñoz,Pablo Prenatal Stress CF1 Mouse Alizarin red Appendicular Skeletal Morphometric Movement restriction Prenatal stress has been associatedwith alterationsin weight andbody size, as well as disturbances inthe process ofdevelopingskeletalossification, occurringduring childbirth and the early stagesof life.However, theeffectevidence of prenatal stresson bone growthand development duringthe gestation periodhas been low; therefore, it is unknown whether these alterations are associated with potential for growth disorders Because of this, thestudy aims todetermine theshort-term effectsof prenatal stress onthe CF-1mouse bone structure growth inyour date of birth. The female mice were divided randomly in two groups: controlled (n=2) and stressed (n=3). The latter was put under stress by means of movement restriction during the last week of gestation. Second, an evaluation of their gestational development was made, obtaining measurements of their weight. Finally, diaphanization with KOH and staining with Alizarin red was used to measure the length of their appendicular bones and their flat pelvic bones, of 53 P0 mice (25 control; 28 stressed during gestation). The stressed mice's body weight (p=0.02) and the length of their appendicular bones (radii, p=0.0011; ulnae, p= 0.0001; humeri, p=0.0001; femorae, p=0.0006; tibiae, p=0.0015) were affected significantly in contrast with the controlled group. On the other hand,there were nosignificant differences inmaternal bodyweightand length ofthe mice pelvic bones (isquium, ilium; p>0.05). The prenatal stress by means of movement restriction alters the osseous appendicular morphology of the CF-1 mouse evaluated at birth.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.30 n.3 20122012-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000300059en10.4067/S0717-95022012000300059
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Prenatal Stress CF1 Mouse Alizarin red Appendicular Skeletal Morphometric Movement restriction
spellingShingle	Prenatal Stress CF1 Mouse Alizarin red Appendicular Skeletal Morphometric Movement restriction Lizana,Pablo Henríquez,Ricardo Muñoz,Pablo Prenatal Stress Caused by Movement Restriction Induces Changes in the Appendicular Osseous Development of CF-1 Mice Progeny
description	Prenatal stress has been associatedwith alterationsin weight andbody size, as well as disturbances inthe process ofdevelopingskeletalossification, occurringduring childbirth and the early stagesof life.However, theeffectevidence of prenatal stresson bone growthand development duringthe gestation periodhas been low; therefore, it is unknown whether these alterations are associated with potential for growth disorders Because of this, thestudy aims todetermine theshort-term effectsof prenatal stress onthe CF-1mouse bone structure growth inyour date of birth. The female mice were divided randomly in two groups: controlled (n=2) and stressed (n=3). The latter was put under stress by means of movement restriction during the last week of gestation. Second, an evaluation of their gestational development was made, obtaining measurements of their weight. Finally, diaphanization with KOH and staining with Alizarin red was used to measure the length of their appendicular bones and their flat pelvic bones, of 53 P0 mice (25 control; 28 stressed during gestation). The stressed mice's body weight (p=0.02) and the length of their appendicular bones (radii, p=0.0011; ulnae, p= 0.0001; humeri, p=0.0001; femorae, p=0.0006; tibiae, p=0.0015) were affected significantly in contrast with the controlled group. On the other hand,there were nosignificant differences inmaternal bodyweightand length ofthe mice pelvic bones (isquium, ilium; p>0.05). The prenatal stress by means of movement restriction alters the osseous appendicular morphology of the CF-1 mouse evaluated at birth.
author	Lizana,Pablo Henríquez,Ricardo Muñoz,Pablo
author_facet	Lizana,Pablo Henríquez,Ricardo Muñoz,Pablo
author_sort	Lizana,Pablo
title	Prenatal Stress Caused by Movement Restriction Induces Changes in the Appendicular Osseous Development of CF-1 Mice Progeny
title_short	Prenatal Stress Caused by Movement Restriction Induces Changes in the Appendicular Osseous Development of CF-1 Mice Progeny
title_full	Prenatal Stress Caused by Movement Restriction Induces Changes in the Appendicular Osseous Development of CF-1 Mice Progeny
title_fullStr	Prenatal Stress Caused by Movement Restriction Induces Changes in the Appendicular Osseous Development of CF-1 Mice Progeny
title_full_unstemmed	Prenatal Stress Caused by Movement Restriction Induces Changes in the Appendicular Osseous Development of CF-1 Mice Progeny
title_sort	prenatal stress caused by movement restriction induces changes in the appendicular osseous development of cf-1 mice progeny
publisher	Sociedad Chilena de Anatomía
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000300059
work_keys_str_mv	AT lizanapablo prenatalstresscausedbymovementrestrictioninduceschangesintheappendicularosseousdevelopmentofcf1miceprogeny AT henriquezricardo prenatalstresscausedbymovementrestrictioninduceschangesintheappendicularosseousdevelopmentofcf1miceprogeny AT munozpablo prenatalstresscausedbymovementrestrictioninduceschangesintheappendicularosseousdevelopmentofcf1miceprogeny
_version_	1718444797339893760

Prenatal Stress Caused by Movement Restriction Induces Changes in the Appendicular Osseous Development of CF-1 Mice Progeny

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