Correlation between Innervation of Skeletal Muscles and Myoblast Stem Cells
In order to explore the change rule of myoblast stem cells (satellite cells, SCs) in the denervated and re-innervated muscle and to investigate the cellular mechanism of the morphological and functional changes of the muscle, denervated muscle atrophy and nerve regeneration models were established i...
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| Lenguaje: | English |
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Sociedad Chilena de Anatomía
2012
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oai:scielo:S0717-950220120004000432013-06-20Correlation between Innervation of Skeletal Muscles and Myoblast Stem CellsWu,JiangSun,XiaojuanZhu,MinZhu,ChongtaoChen,BinXu,YongqingOuyang,JunLiao,HuaQiu,Xiaozhong Satellite cells Atrophy Denervation Innervations Stem cells In order to explore the change rule of myoblast stem cells (satellite cells, SCs) in the denervated and re-innervated muscle and to investigate the cellular mechanism of the morphological and functional changes of the muscle, denervated muscle atrophy and nerve regeneration models were established in one-month-old rats. Postoperative indexes such as muscle wet weight, cell section areas, content of collagen fibers and DNA, electrophysiology, numbers of SCs in the triceps muscle of calf were dynamically tested. After denervation, the muscle wet weight and cell area reduced rapidly, and the collagen fiber content increased slowly. The number of SCs increased at first, and then declined suddenly two months later. From 4 to 5 weeks after re-neuralization, muscle action potentials could be evoked, but the best innervation effect was found in the groups, which received re-neuralization at 2 months and 3 months after denervation. Denervation causes a progressive progress of muscle atrophy. SCs proliferate within 3 months after denervation, and then atrophy becomes irreversible from 4 months. At 4 or 5 weeks after re-neuralization, muscle action potentials can be evoked. Re-neuralization at 2 months and 3 months after denervation can achieve a good effect on the functional recovery of the atrophic muscle.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.30 n.4 20122012-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000400043en10.4067/S0717-95022012000400043 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Satellite cells Atrophy Denervation Innervations Stem cells |
| spellingShingle |
Satellite cells Atrophy Denervation Innervations Stem cells Wu,Jiang Sun,Xiaojuan Zhu,Min Zhu,Chongtao Chen,Bin Xu,Yongqing Ouyang,Jun Liao,Hua Qiu,Xiaozhong Correlation between Innervation of Skeletal Muscles and Myoblast Stem Cells |
| description |
In order to explore the change rule of myoblast stem cells (satellite cells, SCs) in the denervated and re-innervated muscle and to investigate the cellular mechanism of the morphological and functional changes of the muscle, denervated muscle atrophy and nerve regeneration models were established in one-month-old rats. Postoperative indexes such as muscle wet weight, cell section areas, content of collagen fibers and DNA, electrophysiology, numbers of SCs in the triceps muscle of calf were dynamically tested. After denervation, the muscle wet weight and cell area reduced rapidly, and the collagen fiber content increased slowly. The number of SCs increased at first, and then declined suddenly two months later. From 4 to 5 weeks after re-neuralization, muscle action potentials could be evoked, but the best innervation effect was found in the groups, which received re-neuralization at 2 months and 3 months after denervation. Denervation causes a progressive progress of muscle atrophy. SCs proliferate within 3 months after denervation, and then atrophy becomes irreversible from 4 months. At 4 or 5 weeks after re-neuralization, muscle action potentials can be evoked. Re-neuralization at 2 months and 3 months after denervation can achieve a good effect on the functional recovery of the atrophic muscle. |
| author |
Wu,Jiang Sun,Xiaojuan Zhu,Min Zhu,Chongtao Chen,Bin Xu,Yongqing Ouyang,Jun Liao,Hua Qiu,Xiaozhong |
| author_facet |
Wu,Jiang Sun,Xiaojuan Zhu,Min Zhu,Chongtao Chen,Bin Xu,Yongqing Ouyang,Jun Liao,Hua Qiu,Xiaozhong |
| author_sort |
Wu,Jiang |
| title |
Correlation between Innervation of Skeletal Muscles and Myoblast Stem Cells |
| title_short |
Correlation between Innervation of Skeletal Muscles and Myoblast Stem Cells |
| title_full |
Correlation between Innervation of Skeletal Muscles and Myoblast Stem Cells |
| title_fullStr |
Correlation between Innervation of Skeletal Muscles and Myoblast Stem Cells |
| title_full_unstemmed |
Correlation between Innervation of Skeletal Muscles and Myoblast Stem Cells |
| title_sort |
correlation between innervation of skeletal muscles and myoblast stem cells |
| publisher |
Sociedad Chilena de Anatomía |
| publishDate |
2012 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000400043 |
| work_keys_str_mv |
AT wujiang correlationbetweeninnervationofskeletalmusclesandmyoblaststemcells AT sunxiaojuan correlationbetweeninnervationofskeletalmusclesandmyoblaststemcells AT zhumin correlationbetweeninnervationofskeletalmusclesandmyoblaststemcells AT zhuchongtao correlationbetweeninnervationofskeletalmusclesandmyoblaststemcells AT chenbin correlationbetweeninnervationofskeletalmusclesandmyoblaststemcells AT xuyongqing correlationbetweeninnervationofskeletalmusclesandmyoblaststemcells AT ouyangjun correlationbetweeninnervationofskeletalmusclesandmyoblaststemcells AT liaohua correlationbetweeninnervationofskeletalmusclesandmyoblaststemcells AT qiuxiaozhong correlationbetweeninnervationofskeletalmusclesandmyoblaststemcells |
| _version_ |
1718444806542196736 |