The Role of Antioxidants in Cerebellar Development: A Review of Literature

Developmental pathologies may result from endogenous or xenobiotic-enhanced formation of reacting oxygen species (ROS), which oxidatively damage cellular macromolecules and/or alter signal transduction, and that the embryonic processes regulating the balance of ROS formation, oxidative DNA damage an...

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Autor principal:	Imosemi,I. O
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2013
Materias:	Cerebellar development Reacting oxygen species Oxidative stress Antioxidants
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000100034
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spelling	oai:scielo:S0717-950220130001000342014-09-09The Role of Antioxidants in Cerebellar Development: A Review of LiteratureImosemi,I. O Cerebellar development Reacting oxygen species Oxidative stress Antioxidants Developmental pathologies may result from endogenous or xenobiotic-enhanced formation of reacting oxygen species (ROS), which oxidatively damage cellular macromolecules and/or alter signal transduction, and that the embryonic processes regulating the balance of ROS formation, oxidative DNA damage and repair, and ROS-mediated signal transduction may be important determinants of teratological risk. ROS can oxidize molecular targets such as DNA, protein, lipid in a process called oxidative stress resulting in cellular dysfunction and in utero death or teratogenicity. This review, consisting of literature search of journals and chapters in books aims at highlighting the importance of the cerebellum in controlling various motor activities in the body, as well as substances affecting cerebellar development with a view of providing an insight to the role antioxidants play in cerebellar development. It is interesting to note that the developing brain (especially the cerebellum, cerebrum and hippocampus) is highly vulnerable to the deleterious effects of ROS. Studies have shown that exposure to oxidants in the first trimester is associated with an increased risk of major congenital anomalies, as most vital organs in the body develop and some become functional within this period in offspring. Antioxidants may prevent oxidative damage in degenerative diseases including ageing, cardiovascular diseases, cancer, Alzheimer's disease, stroke and Parkinson's disease as such play a critical role in wellness and health maintenance.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.31 n.1 20132013-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000100034en10.4067/S0717-95022013000100034
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Cerebellar development Reacting oxygen species Oxidative stress Antioxidants
spellingShingle	Cerebellar development Reacting oxygen species Oxidative stress Antioxidants Imosemi,I. O The Role of Antioxidants in Cerebellar Development: A Review of Literature
description	Developmental pathologies may result from endogenous or xenobiotic-enhanced formation of reacting oxygen species (ROS), which oxidatively damage cellular macromolecules and/or alter signal transduction, and that the embryonic processes regulating the balance of ROS formation, oxidative DNA damage and repair, and ROS-mediated signal transduction may be important determinants of teratological risk. ROS can oxidize molecular targets such as DNA, protein, lipid in a process called oxidative stress resulting in cellular dysfunction and in utero death or teratogenicity. This review, consisting of literature search of journals and chapters in books aims at highlighting the importance of the cerebellum in controlling various motor activities in the body, as well as substances affecting cerebellar development with a view of providing an insight to the role antioxidants play in cerebellar development. It is interesting to note that the developing brain (especially the cerebellum, cerebrum and hippocampus) is highly vulnerable to the deleterious effects of ROS. Studies have shown that exposure to oxidants in the first trimester is associated with an increased risk of major congenital anomalies, as most vital organs in the body develop and some become functional within this period in offspring. Antioxidants may prevent oxidative damage in degenerative diseases including ageing, cardiovascular diseases, cancer, Alzheimer's disease, stroke and Parkinson's disease as such play a critical role in wellness and health maintenance.
author	Imosemi,I. O
author_facet	Imosemi,I. O
author_sort	Imosemi,I. O
title	The Role of Antioxidants in Cerebellar Development: A Review of Literature
title_short	The Role of Antioxidants in Cerebellar Development: A Review of Literature
title_full	The Role of Antioxidants in Cerebellar Development: A Review of Literature
title_fullStr	The Role of Antioxidants in Cerebellar Development: A Review of Literature
title_full_unstemmed	The Role of Antioxidants in Cerebellar Development: A Review of Literature
title_sort	role of antioxidants in cerebellar development: a review of literature
publisher	Sociedad Chilena de Anatomía
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000100034
work_keys_str_mv	AT imosemiio theroleofantioxidantsincerebellardevelopmentareviewofliterature AT imosemiio roleofantioxidantsincerebellardevelopmentareviewofliterature
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The Role of Antioxidants in Cerebellar Development: A Review of Literature

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