Histopathology of Organs from Neonate Offspring Born to Female Rats Exposed to Sublethal Doses of Biological and Synthetic Insecticides

The current annual consumption of insecticides in agriculture in Brazil is over three million tons. The exposure happens through food that is contaminated with toxic waste and respiratory and dermal absorption. Biological control with Bacillus thuringiensis Berliner (Bt) has assumed increasing impor...

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Autores principales:	dos Santos,Hilda Michelly Paiva, Teixeira,Valéria Wanderley, Teixeira,Álvaro Aguiar Coelho, da Silva,Rosimere, Lemos,Ana Janaina Jeanine Martins, Neto,Clovis José Cavalcanti Lapa, Ferreira,Cintia Giselle Martins
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2013
Materias:	Bacillus thuringiensis Synthetic insecticide Rats Histology Histochemistry
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000100040
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spelling	oai:scielo:S0717-950220130001000402014-09-09Histopathology of Organs from Neonate Offspring Born to Female Rats Exposed to Sublethal Doses of Biological and Synthetic Insecticidesdos Santos,Hilda Michelly PaivaTeixeira,Valéria WanderleyTeixeira,Álvaro Aguiar Coelhoda Silva,RosimereLemos,Ana Janaina Jeanine MartinsNeto,Clovis José Cavalcanti LapaFerreira,Cintia Giselle Martins Bacillus thuringiensis Synthetic insecticide Rats Histology Histochemistry The current annual consumption of insecticides in agriculture in Brazil is over three million tons. The exposure happens through food that is contaminated with toxic waste and respiratory and dermal absorption. Biological control with Bacillus thuringiensis Berliner (Bt) has assumed increasing importance replacing the use of conventional insecticides. However, the tests used to justify approval for use and market release of Bt products, and the protocols used to assess the development of toxicity, are extremely superficial. In addition, more studies comparing effects between males and females and during pregnancy and lactation have not been conducted. Thus, the hypothesis tested in this study was if the administration of the XenTari® WG (Bacillus thuringiensis subsp. Aizawai) biological insecticide and Decis® 25CE (Deltamethrin) synthetic insecticide, at concentrations that do not cause clinical signs of maternal toxicity, could interfere in the histophysiology of the organs of neonate rats. Thirty-five pregnant albino rats, Rattus norvegicus albinus, were randomly distributed in seven groups: Group I received placebo (water); Groups II, III, and IV received 1.0, 10.0, and 20.0 mg of XenTari®/kg respectively; and Groups V, VI, and VII received 1.0, 2.0, and 4.0 mg of Deltamethrin/kg, respectively. The results showed that the highest doses of insecticides reduced the number of neonates. No histopathological alterations were observed in the kidneys, however, lipidosis, diffuse mononuclear inflammatory cells, and sinusoids congestion were observed in the liver. Rats from groups IV and VII presented atresia in the ovaries. Neonates from Group IV showed congestion and hemosiderin deposition in the testicle's blood vessels, which is characteristic of a process of hemolysis. In conclusion, both insecticides presented similar effects on organs and number of neonates born to rats exposed to sub-lethal doses that did not cause clinical symptoms of maternal intoxication.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.31 n.1 20132013-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000100040en10.4067/S0717-95022013000100040
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Bacillus thuringiensis Synthetic insecticide Rats Histology Histochemistry
spellingShingle	Bacillus thuringiensis Synthetic insecticide Rats Histology Histochemistry dos Santos,Hilda Michelly Paiva Teixeira,Valéria Wanderley Teixeira,Álvaro Aguiar Coelho da Silva,Rosimere Lemos,Ana Janaina Jeanine Martins Neto,Clovis José Cavalcanti Lapa Ferreira,Cintia Giselle Martins Histopathology of Organs from Neonate Offspring Born to Female Rats Exposed to Sublethal Doses of Biological and Synthetic Insecticides
description	The current annual consumption of insecticides in agriculture in Brazil is over three million tons. The exposure happens through food that is contaminated with toxic waste and respiratory and dermal absorption. Biological control with Bacillus thuringiensis Berliner (Bt) has assumed increasing importance replacing the use of conventional insecticides. However, the tests used to justify approval for use and market release of Bt products, and the protocols used to assess the development of toxicity, are extremely superficial. In addition, more studies comparing effects between males and females and during pregnancy and lactation have not been conducted. Thus, the hypothesis tested in this study was if the administration of the XenTari® WG (Bacillus thuringiensis subsp. Aizawai) biological insecticide and Decis® 25CE (Deltamethrin) synthetic insecticide, at concentrations that do not cause clinical signs of maternal toxicity, could interfere in the histophysiology of the organs of neonate rats. Thirty-five pregnant albino rats, Rattus norvegicus albinus, were randomly distributed in seven groups: Group I received placebo (water); Groups II, III, and IV received 1.0, 10.0, and 20.0 mg of XenTari®/kg respectively; and Groups V, VI, and VII received 1.0, 2.0, and 4.0 mg of Deltamethrin/kg, respectively. The results showed that the highest doses of insecticides reduced the number of neonates. No histopathological alterations were observed in the kidneys, however, lipidosis, diffuse mononuclear inflammatory cells, and sinusoids congestion were observed in the liver. Rats from groups IV and VII presented atresia in the ovaries. Neonates from Group IV showed congestion and hemosiderin deposition in the testicle's blood vessels, which is characteristic of a process of hemolysis. In conclusion, both insecticides presented similar effects on organs and number of neonates born to rats exposed to sub-lethal doses that did not cause clinical symptoms of maternal intoxication.
author	dos Santos,Hilda Michelly Paiva Teixeira,Valéria Wanderley Teixeira,Álvaro Aguiar Coelho da Silva,Rosimere Lemos,Ana Janaina Jeanine Martins Neto,Clovis José Cavalcanti Lapa Ferreira,Cintia Giselle Martins
author_facet	dos Santos,Hilda Michelly Paiva Teixeira,Valéria Wanderley Teixeira,Álvaro Aguiar Coelho da Silva,Rosimere Lemos,Ana Janaina Jeanine Martins Neto,Clovis José Cavalcanti Lapa Ferreira,Cintia Giselle Martins
author_sort	dos Santos,Hilda Michelly Paiva
title	Histopathology of Organs from Neonate Offspring Born to Female Rats Exposed to Sublethal Doses of Biological and Synthetic Insecticides
title_short	Histopathology of Organs from Neonate Offspring Born to Female Rats Exposed to Sublethal Doses of Biological and Synthetic Insecticides
title_full	Histopathology of Organs from Neonate Offspring Born to Female Rats Exposed to Sublethal Doses of Biological and Synthetic Insecticides
title_fullStr	Histopathology of Organs from Neonate Offspring Born to Female Rats Exposed to Sublethal Doses of Biological and Synthetic Insecticides
title_full_unstemmed	Histopathology of Organs from Neonate Offspring Born to Female Rats Exposed to Sublethal Doses of Biological and Synthetic Insecticides
title_sort	histopathology of organs from neonate offspring born to female rats exposed to sublethal doses of biological and synthetic insecticides
publisher	Sociedad Chilena de Anatomía
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000100040
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Histopathology of Organs from Neonate Offspring Born to Female Rats Exposed to Sublethal Doses of Biological and Synthetic Insecticides

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