The Histo-morphometric Evidences of Vernonia amygdalina Leaf Extract-induced Testicular Toxicity

Vernonia amygdalina (bitter-leaf) is native to West Africa but occurs mostly in its cultivated form in various parts of central and southern Nigeria. It is a dark-green leafy vegetable commonly used in cooking and as folkloric medicine for the management of several diseases in Nigeria. In the presen...

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Autores principales:	Saalu,L. C, Akunna,G. G, Oyewopo,A. O
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2013
Materias:	Vernonia amygdalina Histology Morphometry Testis Wistar rat
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000200052
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spelling	oai:scielo:S0717-950220130002000522014-09-09The Histo-morphometric Evidences of Vernonia amygdalina Leaf Extract-induced Testicular ToxicitySaalu,L. CAkunna,G. GOyewopo,A. O Vernonia amygdalina Histology Morphometry Testis Wistar rat Vernonia amygdalina (bitter-leaf) is native to West Africa but occurs mostly in its cultivated form in various parts of central and southern Nigeria. It is a dark-green leafy vegetable commonly used in cooking and as folkloric medicine for the management of several diseases in Nigeria. In the present study, the effects of varying doses of ethanolic leaf extract of Vernonia amygdalina on the rat testis histo-morphometry were investigated. Forty male wistar rats were divided into groups of four. Group A, as the control was given 10 ml/kg/day/oral distilled water while Group B, C and D subsequently treated with 100, 300 and 600 mg/kg/day/oral route Vernonia amygdalina leaves extract respectively for 56 days. Results showed that Group B rats had normal testis histology comparable to the control group. However, rats in Group C and D exhibited dose-dependent poor testes histo-morphometric profiles, with the higher dosage-group (D) providing a worse feature. Thus, there was a statistically significant (p < 0.05) reduction in the tubular diameter, cross-sectional area of the tubules, number of tubular profiles per unit area and the mean numerical density of seminiferous tubules of Group C and Group D animals compared to the control group. Our results therefore indicated that, while the lower dose (100 mg/kg) of Vernonia amygdalina leaves extract can be accommodated by rat testis, the higher doses (300 mg/kg and 600 mg/kg) demonstrate testicular toxicity in the rat.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.31 n.2 20132013-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000200052en10.4067/S0717-95022013000200052
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Vernonia amygdalina Histology Morphometry Testis Wistar rat
spellingShingle	Vernonia amygdalina Histology Morphometry Testis Wistar rat Saalu,L. C Akunna,G. G Oyewopo,A. O The Histo-morphometric Evidences of Vernonia amygdalina Leaf Extract-induced Testicular Toxicity
description	Vernonia amygdalina (bitter-leaf) is native to West Africa but occurs mostly in its cultivated form in various parts of central and southern Nigeria. It is a dark-green leafy vegetable commonly used in cooking and as folkloric medicine for the management of several diseases in Nigeria. In the present study, the effects of varying doses of ethanolic leaf extract of Vernonia amygdalina on the rat testis histo-morphometry were investigated. Forty male wistar rats were divided into groups of four. Group A, as the control was given 10 ml/kg/day/oral distilled water while Group B, C and D subsequently treated with 100, 300 and 600 mg/kg/day/oral route Vernonia amygdalina leaves extract respectively for 56 days. Results showed that Group B rats had normal testis histology comparable to the control group. However, rats in Group C and D exhibited dose-dependent poor testes histo-morphometric profiles, with the higher dosage-group (D) providing a worse feature. Thus, there was a statistically significant (p < 0.05) reduction in the tubular diameter, cross-sectional area of the tubules, number of tubular profiles per unit area and the mean numerical density of seminiferous tubules of Group C and Group D animals compared to the control group. Our results therefore indicated that, while the lower dose (100 mg/kg) of Vernonia amygdalina leaves extract can be accommodated by rat testis, the higher doses (300 mg/kg and 600 mg/kg) demonstrate testicular toxicity in the rat.
author	Saalu,L. C Akunna,G. G Oyewopo,A. O
author_facet	Saalu,L. C Akunna,G. G Oyewopo,A. O
author_sort	Saalu,L. C
title	The Histo-morphometric Evidences of Vernonia amygdalina Leaf Extract-induced Testicular Toxicity
title_short	The Histo-morphometric Evidences of Vernonia amygdalina Leaf Extract-induced Testicular Toxicity
title_full	The Histo-morphometric Evidences of Vernonia amygdalina Leaf Extract-induced Testicular Toxicity
title_fullStr	The Histo-morphometric Evidences of Vernonia amygdalina Leaf Extract-induced Testicular Toxicity
title_full_unstemmed	The Histo-morphometric Evidences of Vernonia amygdalina Leaf Extract-induced Testicular Toxicity
title_sort	histo-morphometric evidences of vernonia amygdalina leaf extract-induced testicular toxicity
publisher	Sociedad Chilena de Anatomía
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000200052
work_keys_str_mv	AT saalulc thehistomorphometricevidencesofvernoniaamygdalinaleafextractinducedtesticulartoxicity AT akunnagg thehistomorphometricevidencesofvernoniaamygdalinaleafextractinducedtesticulartoxicity AT oyewopoao thehistomorphometricevidencesofvernoniaamygdalinaleafextractinducedtesticulartoxicity AT saalulc histomorphometricevidencesofvernoniaamygdalinaleafextractinducedtesticulartoxicity AT akunnagg histomorphometricevidencesofvernoniaamygdalinaleafextractinducedtesticulartoxicity AT oyewopoao histomorphometricevidencesofvernoniaamygdalinaleafextractinducedtesticulartoxicity
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The Histo-morphometric Evidences of Vernonia amygdalina Leaf Extract-induced Testicular Toxicity

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