Cellular Responses in the Respiratory Tract Following Intranasal administration of Peste des petits Ruminant Vaccine in Goats

A trial was conducted to compare the cellular responses in the respiratory tract in intranasal vaccination against caprine Peste des petits ruminant lineage 1 variant virus infection with intramuscular and subcutaneous vaccinations in order to elucidate the mechanism of the protection. Twenty four g...

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Autores principales:	Ezeasor,C. V, Emikpe,B. O, Yussof,Sabri M, Afusat,Jagun, Anosa,V. O
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2013
Materias:	Cellular responses Intranasal administration Peste des petits ruminant vaccine Goats
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000200056
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spelling	oai:scielo:S0717-950220130002000562014-09-09Cellular Responses in the Respiratory Tract Following Intranasal administration of Peste des petits Ruminant Vaccine in GoatsEzeasor,C. VEmikpe,B. OYussof,Sabri MAfusat,JagunAnosa,V. O Cellular responses Intranasal administration Peste des petits ruminant vaccine Goats A trial was conducted to compare the cellular responses in the respiratory tract in intranasal vaccination against caprine Peste des petits ruminant lineage 1 variant virus infection with intramuscular and subcutaneous vaccinations in order to elucidate the mechanism of the protection. Twenty four goats were divided into four equal groups. Group 1 was vaccinated intranasaly, group 2 was vaccinated subcutaneously, and group 3 intramuscularly, while Group 4 was the unvaccinated control group. In each group the vaccinations were carried out once. All goats were challenged intratrachealy with PPR virus at a concentration of 106.5 TCID50 two weeks after vaccination and were euthanised 21 days after the challenge. The bronchoalveolar lavage differential count, bronchial associated lymphoid tissue (BALT) responses were measured using standard techniques. Descriptive Statistics and ANOVA was employed and significance was at p < 0.05. The exposure also resulted into significant increase in the number and size of BALT as well as the number of lymphocytes in BALT. This study showed the mechanism of the protective effect of intranasal vaccination of PPR vaccine observed with the strong mucosal and defensive cellular responses in the respiratory tract observed than the subcutaneous and intramuscular routes.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.31 n.2 20132013-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000200056en10.4067/S0717-95022013000200056
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Cellular responses Intranasal administration Peste des petits ruminant vaccine Goats
spellingShingle	Cellular responses Intranasal administration Peste des petits ruminant vaccine Goats Ezeasor,C. V Emikpe,B. O Yussof,Sabri M Afusat,Jagun Anosa,V. O Cellular Responses in the Respiratory Tract Following Intranasal administration of Peste des petits Ruminant Vaccine in Goats
description	A trial was conducted to compare the cellular responses in the respiratory tract in intranasal vaccination against caprine Peste des petits ruminant lineage 1 variant virus infection with intramuscular and subcutaneous vaccinations in order to elucidate the mechanism of the protection. Twenty four goats were divided into four equal groups. Group 1 was vaccinated intranasaly, group 2 was vaccinated subcutaneously, and group 3 intramuscularly, while Group 4 was the unvaccinated control group. In each group the vaccinations were carried out once. All goats were challenged intratrachealy with PPR virus at a concentration of 106.5 TCID50 two weeks after vaccination and were euthanised 21 days after the challenge. The bronchoalveolar lavage differential count, bronchial associated lymphoid tissue (BALT) responses were measured using standard techniques. Descriptive Statistics and ANOVA was employed and significance was at p < 0.05. The exposure also resulted into significant increase in the number and size of BALT as well as the number of lymphocytes in BALT. This study showed the mechanism of the protective effect of intranasal vaccination of PPR vaccine observed with the strong mucosal and defensive cellular responses in the respiratory tract observed than the subcutaneous and intramuscular routes.
author	Ezeasor,C. V Emikpe,B. O Yussof,Sabri M Afusat,Jagun Anosa,V. O
author_facet	Ezeasor,C. V Emikpe,B. O Yussof,Sabri M Afusat,Jagun Anosa,V. O
author_sort	Ezeasor,C. V
title	Cellular Responses in the Respiratory Tract Following Intranasal administration of Peste des petits Ruminant Vaccine in Goats
title_short	Cellular Responses in the Respiratory Tract Following Intranasal administration of Peste des petits Ruminant Vaccine in Goats
title_full	Cellular Responses in the Respiratory Tract Following Intranasal administration of Peste des petits Ruminant Vaccine in Goats
title_fullStr	Cellular Responses in the Respiratory Tract Following Intranasal administration of Peste des petits Ruminant Vaccine in Goats
title_full_unstemmed	Cellular Responses in the Respiratory Tract Following Intranasal administration of Peste des petits Ruminant Vaccine in Goats
title_sort	cellular responses in the respiratory tract following intranasal administration of peste des petits ruminant vaccine in goats
publisher	Sociedad Chilena de Anatomía
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000200056
work_keys_str_mv	AT ezeasorcv cellularresponsesintherespiratorytractfollowingintranasaladministrationofpestedespetitsruminantvaccineingoats AT emikpebo cellularresponsesintherespiratorytractfollowingintranasaladministrationofpestedespetitsruminantvaccineingoats AT yussofsabrim cellularresponsesintherespiratorytractfollowingintranasaladministrationofpestedespetitsruminantvaccineingoats AT afusatjagun cellularresponsesintherespiratorytractfollowingintranasaladministrationofpestedespetitsruminantvaccineingoats AT anosavo cellularresponsesintherespiratorytractfollowingintranasaladministrationofpestedespetitsruminantvaccineingoats
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Cellular Responses in the Respiratory Tract Following Intranasal administration of Peste des petits Ruminant Vaccine in Goats

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