Protective Role of Melatonin in Mouse Spermatogenesis Induced by Sodium Arsenite

Arsenic is a testicular environmental toxic. Melatonin (Me), being a potent antioxidant, may reduce the damage caused by arsenic in male fertility. The effects of daily oral exposure of Sodium Arsenite (As; 7.0 mg/kg/bw); Melatonin (Me, 10.0 mg/kg/bw); Me (10.0 mg/kg/bw) plus As (7.0 mg/kg/bw), and...

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Autores principales:	Bustos-Obregón,Eduardo, Poblete,Daniel, Catriao,Roberto, Fernandes,Fábio Henrique
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2013
Materias:	Mouse Arsenic COX-2 Androgen receptor Oxidative stress Melatonin
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000300012
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spelling	oai:scielo:S0717-950220130003000122013-12-03Protective Role of Melatonin in Mouse Spermatogenesis Induced by Sodium ArseniteBustos-Obregón,EduardoPoblete,DanielCatriao,RobertoFernandes,Fábio Henrique Mouse Arsenic COX-2 Androgen receptor Oxidative stress Melatonin Arsenic is a testicular environmental toxic. Melatonin (Me), being a potent antioxidant, may reduce the damage caused by arsenic in male fertility. The effects of daily oral exposure of Sodium Arsenite (As; 7.0 mg/kg/bw); Melatonin (Me, 10.0 mg/kg/bw); Me (10.0 mg/kg/bw) plus As (7.0 mg/kg/bw), and Negative Control (NaCl 0.9%) in male CF-1 adult mice were assessed in acute (8.3 days), chronic (33.2 days) and recovery (66,4 days) of testicular damage. We evaluated changes in testicular weight and histopathological, morphometric measurements, expression of COX-2 and Androgen Receptor (AR) antigens and lipid peroxidation levels. Treatment resulted in decreased tubular diameter and AR expression, and increased: interstitial area, luminal diameter, COX-2 expression levels and of lipid peroxidation. Co-administration of As and Me partially decreased germ cell degeneration and AR expression levels, improving testicular histopathological parameters. These results indicate that As causes toxicity and testicular germ cell degeneration by induction of oxidative stress. Me partially protects from this damage in mouse testis, acting as scavenger of oxygen radical species.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.31 n.3 20132013-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000300012en10.4067/S0717-95022013000300012
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Mouse Arsenic COX-2 Androgen receptor Oxidative stress Melatonin
spellingShingle	Mouse Arsenic COX-2 Androgen receptor Oxidative stress Melatonin Bustos-Obregón,Eduardo Poblete,Daniel Catriao,Roberto Fernandes,Fábio Henrique Protective Role of Melatonin in Mouse Spermatogenesis Induced by Sodium Arsenite
description	Arsenic is a testicular environmental toxic. Melatonin (Me), being a potent antioxidant, may reduce the damage caused by arsenic in male fertility. The effects of daily oral exposure of Sodium Arsenite (As; 7.0 mg/kg/bw); Melatonin (Me, 10.0 mg/kg/bw); Me (10.0 mg/kg/bw) plus As (7.0 mg/kg/bw), and Negative Control (NaCl 0.9%) in male CF-1 adult mice were assessed in acute (8.3 days), chronic (33.2 days) and recovery (66,4 days) of testicular damage. We evaluated changes in testicular weight and histopathological, morphometric measurements, expression of COX-2 and Androgen Receptor (AR) antigens and lipid peroxidation levels. Treatment resulted in decreased tubular diameter and AR expression, and increased: interstitial area, luminal diameter, COX-2 expression levels and of lipid peroxidation. Co-administration of As and Me partially decreased germ cell degeneration and AR expression levels, improving testicular histopathological parameters. These results indicate that As causes toxicity and testicular germ cell degeneration by induction of oxidative stress. Me partially protects from this damage in mouse testis, acting as scavenger of oxygen radical species.
author	Bustos-Obregón,Eduardo Poblete,Daniel Catriao,Roberto Fernandes,Fábio Henrique
author_facet	Bustos-Obregón,Eduardo Poblete,Daniel Catriao,Roberto Fernandes,Fábio Henrique
author_sort	Bustos-Obregón,Eduardo
title	Protective Role of Melatonin in Mouse Spermatogenesis Induced by Sodium Arsenite
title_short	Protective Role of Melatonin in Mouse Spermatogenesis Induced by Sodium Arsenite
title_full	Protective Role of Melatonin in Mouse Spermatogenesis Induced by Sodium Arsenite
title_fullStr	Protective Role of Melatonin in Mouse Spermatogenesis Induced by Sodium Arsenite
title_full_unstemmed	Protective Role of Melatonin in Mouse Spermatogenesis Induced by Sodium Arsenite
title_sort	protective role of melatonin in mouse spermatogenesis induced by sodium arsenite
publisher	Sociedad Chilena de Anatomía
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000300012
work_keys_str_mv	AT bustosobregoneduardo protectiveroleofmelatonininmousespermatogenesisinducedbysodiumarsenite AT pobletedaniel protectiveroleofmelatonininmousespermatogenesisinducedbysodiumarsenite AT catriaoroberto protectiveroleofmelatonininmousespermatogenesisinducedbysodiumarsenite AT fernandesfabiohenrique protectiveroleofmelatonininmousespermatogenesisinducedbysodiumarsenite
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Protective Role of Melatonin in Mouse Spermatogenesis Induced by Sodium Arsenite

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