Effect of Amnion-Wrapped Allogenic Nerve Bridging on Peripheral Nerve Injury

This work aims to investigate the effect of fetal amnion-wrapped acellular allogenic nerve transplantation on peripheral nerve injury (PNI) in dogs and to explore its advantages and feasibility in PNI repair. A total of 15 dogs were divided into three groups: the allogenic nerve transplantation (A),...

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Autores principales:	Zhang,Yan-Ru, Zhang,Ge-Chen, Liu,Qiu-Hao, Wang,Yi-Sheng
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2013
Materias:	Amnion Allogenic transplantation Nerve regeneration
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000300034
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spelling	oai:scielo:S0717-950220130003000342013-12-03Effect of Amnion-Wrapped Allogenic Nerve Bridging on Peripheral Nerve InjuryZhang,Yan-RuZhang,Ge-ChenLiu,Qiu-HaoWang,Yi-Sheng Amnion Allogenic transplantation Nerve regeneration This work aims to investigate the effect of fetal amnion-wrapped acellular allogenic nerve transplantation on peripheral nerve injury (PNI) in dogs and to explore its advantages and feasibility in PNI repair. A total of 15 dogs were divided into three groups: the allogenic nerve transplantation (A), amnion-wrapped allogenic nerve transplantation (B), and allogenic nerve donor (C) groups. Neurite counts after myelin and H-E stainings, soleus muscle action potentials, and sciatic nerve conductive velocities were compared between the A and B groups at 16 w after operation. The B group showed better nerve regeneration than the A group at 16 w. Compared with the A group, the B group showed a better growth continuity of the transplanted nerve and milder inflammatory reactions around the nerve. The B group presented much more proliferated Schwannocytes and regenerated nerve fibers than the A group. The neurite density and the amplitude of the soleus muscle action potentials in the B group were significantly higher than those in the A group (P < 0.05). The two groups did not show significant differences in nerve conductive velocities (P > 0.05). Amnion-wrapped acellular allogenic nerve transplantation can improve defected nerve morphology and the quality of transplanted nerve regeneration.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.31 n.3 20132013-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000300034en10.4067/S0717-95022013000300034
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Amnion Allogenic transplantation Nerve regeneration
spellingShingle	Amnion Allogenic transplantation Nerve regeneration Zhang,Yan-Ru Zhang,Ge-Chen Liu,Qiu-Hao Wang,Yi-Sheng Effect of Amnion-Wrapped Allogenic Nerve Bridging on Peripheral Nerve Injury
description	This work aims to investigate the effect of fetal amnion-wrapped acellular allogenic nerve transplantation on peripheral nerve injury (PNI) in dogs and to explore its advantages and feasibility in PNI repair. A total of 15 dogs were divided into three groups: the allogenic nerve transplantation (A), amnion-wrapped allogenic nerve transplantation (B), and allogenic nerve donor (C) groups. Neurite counts after myelin and H-E stainings, soleus muscle action potentials, and sciatic nerve conductive velocities were compared between the A and B groups at 16 w after operation. The B group showed better nerve regeneration than the A group at 16 w. Compared with the A group, the B group showed a better growth continuity of the transplanted nerve and milder inflammatory reactions around the nerve. The B group presented much more proliferated Schwannocytes and regenerated nerve fibers than the A group. The neurite density and the amplitude of the soleus muscle action potentials in the B group were significantly higher than those in the A group (P < 0.05). The two groups did not show significant differences in nerve conductive velocities (P > 0.05). Amnion-wrapped acellular allogenic nerve transplantation can improve defected nerve morphology and the quality of transplanted nerve regeneration.
author	Zhang,Yan-Ru Zhang,Ge-Chen Liu,Qiu-Hao Wang,Yi-Sheng
author_facet	Zhang,Yan-Ru Zhang,Ge-Chen Liu,Qiu-Hao Wang,Yi-Sheng
author_sort	Zhang,Yan-Ru
title	Effect of Amnion-Wrapped Allogenic Nerve Bridging on Peripheral Nerve Injury
title_short	Effect of Amnion-Wrapped Allogenic Nerve Bridging on Peripheral Nerve Injury
title_full	Effect of Amnion-Wrapped Allogenic Nerve Bridging on Peripheral Nerve Injury
title_fullStr	Effect of Amnion-Wrapped Allogenic Nerve Bridging on Peripheral Nerve Injury
title_full_unstemmed	Effect of Amnion-Wrapped Allogenic Nerve Bridging on Peripheral Nerve Injury
title_sort	effect of amnion-wrapped allogenic nerve bridging on peripheral nerve injury
publisher	Sociedad Chilena de Anatomía
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000300034
work_keys_str_mv	AT zhangyanru effectofamnionwrappedallogenicnervebridgingonperipheralnerveinjury AT zhanggechen effectofamnionwrappedallogenicnervebridgingonperipheralnerveinjury AT liuqiuhao effectofamnionwrappedallogenicnervebridgingonperipheralnerveinjury AT wangyisheng effectofamnionwrappedallogenicnervebridgingonperipheralnerveinjury
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Effect of Amnion-Wrapped Allogenic Nerve Bridging on Peripheral Nerve Injury

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