Increasing of Syncytial Knot and Fibrinoid Deposit in High-Cd Accumulated Human Placentas

A toxic metal, cadmium (Cd), can accumulate in human organs. Placenta is usually used as indicator organ for Cd exposure. Therefore, we aim to investigate the different of placental morphology between the low- and high-Cd accumulated placentas. The samples were collected from 14 pregnant women who r...

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Autores principales:	Phuapittayalert,Laorrat, Norkaew,Thongchai, Supanpaiboon,Wisa, Chuenchoojit,Supaporn, Hipkeao,Wiphawi, Swaddiwudhipong,Witaya, Sakulsak,Natthiya
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2013
Materias:	Cadmium Placenta Syncytial knot Fibrinoid materials
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000400011
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spelling	oai:scielo:S0717-950220130004000112014-02-18Increasing of Syncytial Knot and Fibrinoid Deposit in High-Cd Accumulated Human PlacentasPhuapittayalert,LaorratNorkaew,ThongchaiSupanpaiboon,WisaChuenchoojit,SupapornHipkeao,WiphawiSwaddiwudhipong,WitayaSakulsak,Natthiya Cadmium Placenta Syncytial knot Fibrinoid materials A toxic metal, cadmium (Cd), can accumulate in human organs. Placenta is usually used as indicator organ for Cd exposure. Therefore, we aim to investigate the different of placental morphology between the low- and high-Cd accumulated placentas. The samples were collected from 14 pregnant women who resided in low-Cd contaminated (L-Cd group) and high-Cd contaminated (H-Cd group) areas. The concentrations of Cd in blood (B-Cd), urine (U-Cd) and placentas (P-Cd) were measured by ICP-MS and AAS. The morphological appearance of placentas was examined by using routine paraffin section and H & E staining. The results showed that levels of B-Cd, U-Cd and P-Cd were significantly higher in H-Cd group than in L-Cd group (p= 0.001). Moreover, the B-Cd was positively correlated with U-Cd (rs= 0.823, p= 0.000) and P-Cd concentrations (rs= 0.854, p= 0.000). The appearances of syncytial knot (STK) and fibrinoid deposit (Fd) were obviously greater in H-Cd group than in L-Cd group (p= 0.007, p= 0.026). The STK was positively correlated with both Fd (rs= 0.572, p= 0.032) and P-Cd concentration (rs= 0.766, p= 0.001). Although the chorioamnitis and decidual inflammation features were found in both groups but the appearance in H-Cd group seems to be more severe than in L-Cd group. From these results, we suggested that high Cd level in placenta may be involved in morphological changes, especially STK and Fd increasing and probably disturb the connection between maternal and fetal circulation.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.31 n.4 20132013-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000400011en10.4067/S0717-95022013000400011
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Cadmium Placenta Syncytial knot Fibrinoid materials
spellingShingle	Cadmium Placenta Syncytial knot Fibrinoid materials Phuapittayalert,Laorrat Norkaew,Thongchai Supanpaiboon,Wisa Chuenchoojit,Supaporn Hipkeao,Wiphawi Swaddiwudhipong,Witaya Sakulsak,Natthiya Increasing of Syncytial Knot and Fibrinoid Deposit in High-Cd Accumulated Human Placentas
description	A toxic metal, cadmium (Cd), can accumulate in human organs. Placenta is usually used as indicator organ for Cd exposure. Therefore, we aim to investigate the different of placental morphology between the low- and high-Cd accumulated placentas. The samples were collected from 14 pregnant women who resided in low-Cd contaminated (L-Cd group) and high-Cd contaminated (H-Cd group) areas. The concentrations of Cd in blood (B-Cd), urine (U-Cd) and placentas (P-Cd) were measured by ICP-MS and AAS. The morphological appearance of placentas was examined by using routine paraffin section and H & E staining. The results showed that levels of B-Cd, U-Cd and P-Cd were significantly higher in H-Cd group than in L-Cd group (p= 0.001). Moreover, the B-Cd was positively correlated with U-Cd (rs= 0.823, p= 0.000) and P-Cd concentrations (rs= 0.854, p= 0.000). The appearances of syncytial knot (STK) and fibrinoid deposit (Fd) were obviously greater in H-Cd group than in L-Cd group (p= 0.007, p= 0.026). The STK was positively correlated with both Fd (rs= 0.572, p= 0.032) and P-Cd concentration (rs= 0.766, p= 0.001). Although the chorioamnitis and decidual inflammation features were found in both groups but the appearance in H-Cd group seems to be more severe than in L-Cd group. From these results, we suggested that high Cd level in placenta may be involved in morphological changes, especially STK and Fd increasing and probably disturb the connection between maternal and fetal circulation.
author	Phuapittayalert,Laorrat Norkaew,Thongchai Supanpaiboon,Wisa Chuenchoojit,Supaporn Hipkeao,Wiphawi Swaddiwudhipong,Witaya Sakulsak,Natthiya
author_facet	Phuapittayalert,Laorrat Norkaew,Thongchai Supanpaiboon,Wisa Chuenchoojit,Supaporn Hipkeao,Wiphawi Swaddiwudhipong,Witaya Sakulsak,Natthiya
author_sort	Phuapittayalert,Laorrat
title	Increasing of Syncytial Knot and Fibrinoid Deposit in High-Cd Accumulated Human Placentas
title_short	Increasing of Syncytial Knot and Fibrinoid Deposit in High-Cd Accumulated Human Placentas
title_full	Increasing of Syncytial Knot and Fibrinoid Deposit in High-Cd Accumulated Human Placentas
title_fullStr	Increasing of Syncytial Knot and Fibrinoid Deposit in High-Cd Accumulated Human Placentas
title_full_unstemmed	Increasing of Syncytial Knot and Fibrinoid Deposit in High-Cd Accumulated Human Placentas
title_sort	increasing of syncytial knot and fibrinoid deposit in high-cd accumulated human placentas
publisher	Sociedad Chilena de Anatomía
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000400011
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Increasing of Syncytial Knot and Fibrinoid Deposit in High-Cd Accumulated Human Placentas

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