Nestin-positive Stem Cells Participate in Chondrocyte Renewal in Healthy Adult Lung Cartilage

It is considered that healthy adult cartilage has little or no capacity for renewal, and that chondrocytes maintain a stable resting phenotype and resist proliferation and differentiation throughout life. Recently we found that cell turnover in lung cartilage is possible and that nestin-positive cel...

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Autores principales:	Ortega-Martínez,Marta, de-la-Garza-González,Carlos, Ancer-Rodríguez,Jesús, Jaramillo-Rangel,Gilberto
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2014
Materias:	Cartilage Chondrocyte renewal Nestin Stem cells
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000100026
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spelling	oai:scielo:S0717-950220140001000262015-11-13Nestin-positive Stem Cells Participate in Chondrocyte Renewal in Healthy Adult Lung CartilageOrtega-Martínez,Martade-la-Garza-González,CarlosAncer-Rodríguez,JesúsJaramillo-Rangel,Gilberto Cartilage Chondrocyte renewal Nestin Stem cells It is considered that healthy adult cartilage has little or no capacity for renewal, and that chondrocytes maintain a stable resting phenotype and resist proliferation and differentiation throughout life. Recently we found that cell turnover in lung cartilage is possible and that nestin-positive cells may have a role in it. In this paper, we report additional findings about chondrocyte renewal in lung cartilage. Lung specimens from CD1 mice at the age of 2, 6, 12, 18 or 24 months were fixed in 10% neutral-buffered formalin and paraffin-embedded. Nestin expression was examined by an immunohistochemical peroxidase-based method. We found nestin-positive cells inside of cartilage islets and cells in division very close from them. Our findings indicate that there exist nestin-positive mesenchymal stem cells in the adult that are able to differentiate into lung chondrocytes, perhaps to maintain homeostasis or repair damaged tissue. These findings may improve our knowledge about the cartilage biology and could provide new cell candidates for cartilage tissue engineering.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.32 n.1 20142014-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000100026en10.4067/S0717-95022014000100026
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Cartilage Chondrocyte renewal Nestin Stem cells
spellingShingle	Cartilage Chondrocyte renewal Nestin Stem cells Ortega-Martínez,Marta de-la-Garza-González,Carlos Ancer-Rodríguez,Jesús Jaramillo-Rangel,Gilberto Nestin-positive Stem Cells Participate in Chondrocyte Renewal in Healthy Adult Lung Cartilage
description	It is considered that healthy adult cartilage has little or no capacity for renewal, and that chondrocytes maintain a stable resting phenotype and resist proliferation and differentiation throughout life. Recently we found that cell turnover in lung cartilage is possible and that nestin-positive cells may have a role in it. In this paper, we report additional findings about chondrocyte renewal in lung cartilage. Lung specimens from CD1 mice at the age of 2, 6, 12, 18 or 24 months were fixed in 10% neutral-buffered formalin and paraffin-embedded. Nestin expression was examined by an immunohistochemical peroxidase-based method. We found nestin-positive cells inside of cartilage islets and cells in division very close from them. Our findings indicate that there exist nestin-positive mesenchymal stem cells in the adult that are able to differentiate into lung chondrocytes, perhaps to maintain homeostasis or repair damaged tissue. These findings may improve our knowledge about the cartilage biology and could provide new cell candidates for cartilage tissue engineering.
author	Ortega-Martínez,Marta de-la-Garza-González,Carlos Ancer-Rodríguez,Jesús Jaramillo-Rangel,Gilberto
author_facet	Ortega-Martínez,Marta de-la-Garza-González,Carlos Ancer-Rodríguez,Jesús Jaramillo-Rangel,Gilberto
author_sort	Ortega-Martínez,Marta
title	Nestin-positive Stem Cells Participate in Chondrocyte Renewal in Healthy Adult Lung Cartilage
title_short	Nestin-positive Stem Cells Participate in Chondrocyte Renewal in Healthy Adult Lung Cartilage
title_full	Nestin-positive Stem Cells Participate in Chondrocyte Renewal in Healthy Adult Lung Cartilage
title_fullStr	Nestin-positive Stem Cells Participate in Chondrocyte Renewal in Healthy Adult Lung Cartilage
title_full_unstemmed	Nestin-positive Stem Cells Participate in Chondrocyte Renewal in Healthy Adult Lung Cartilage
title_sort	nestin-positive stem cells participate in chondrocyte renewal in healthy adult lung cartilage
publisher	Sociedad Chilena de Anatomía
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000100026
work_keys_str_mv	AT ortegamartinezmarta nestinpositivestemcellsparticipateinchondrocyterenewalinhealthyadultlungcartilage AT delagarzagonzalezcarlos nestinpositivestemcellsparticipateinchondrocyterenewalinhealthyadultlungcartilage AT ancerrodriguezjesus nestinpositivestemcellsparticipateinchondrocyterenewalinhealthyadultlungcartilage AT jaramillorangelgilberto nestinpositivestemcellsparticipateinchondrocyterenewalinhealthyadultlungcartilage
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Nestin-positive Stem Cells Participate in Chondrocyte Renewal in Healthy Adult Lung Cartilage

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