Animal Models of Nutritional Induction of Type 2 Diabetes Mellitus

Type 2 diabetes mellitus (DM2) is the most common chronic metabolic disease, affecting approximately 6% of the adult population in the Western world. This condition is a major cause of cardiovascular disease, blindness, renal failure, and amputations, with increasing prevalence worldwide. The inuenc...

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Autores principales:	Barbosa-da-Silva,Sandra, Sarmento,Isabele Bringhenti, Bargut,Thereza C. Lonzetti, Souza-Mello,Vanessa, Aguila,Marcia Barbosa, Mandarim-de-Lacerda,Carlos A
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2014
Materias:	Animal models Nutritional induction Metabolic disease Type 2 diabetes mellitus
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000100046
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spelling	oai:scielo:S0717-950220140001000462015-11-13Animal Models of Nutritional Induction of Type 2 Diabetes MellitusBarbosa-da-Silva,SandraSarmento,Isabele BringhentiBargut,Thereza C. LonzettiSouza-Mello,VanessaAguila,Marcia BarbosaMandarim-de-Lacerda,Carlos A Animal models Nutritional induction Metabolic disease Type 2 diabetes mellitus Type 2 diabetes mellitus (DM2) is the most common chronic metabolic disease, affecting approximately 6% of the adult population in the Western world. This condition is a major cause of cardiovascular disease, blindness, renal failure, and amputations, with increasing prevalence worldwide. The inuence of obesity on type 2 diabetes risk is determined by the degree of obesity and by body fat localization, with insulin resistance (IR) being the main link between these metabolic diseases. Experimental studies have shown that dietary factors, and particularly lipids, are strongly positively associated with body mass (BM) gain; IR; and, consequently, type 2 diabetes. Similarly, excessive consumption of energy-dense carbohydrate-rich foods can trigger the onset of type 2 diabetes. Additionally, maternal dietary inadequacies at conception and/or during the gestational period have been proposed to lead to developmental programming of excessive BM gain and metabolic disturbances in offspring, such as abnormal glucose homeostasis, reduced whole-body insulin sensitivity, impaired beta-cell insulin secretion and changes in the structure of the pancreas. Metabolic disruption is strongly associated with deleterious effects on beta-cell development and function. However, alterations in the amount and quality of dietary fat can modify glucose metabolism and insulin sensitivity. In this way, certain oils have gained attention in experimental research for their beneficial effects. Olive oil, a source of monounsaturated fatty acids (MUFAs), got attention in the past for its capacity to prevent cardiovascular diseases. Nevertheless, it is currently known that this oil also improves insulin sensitivity and glycemic control. Canola oil, flaxseed oil and especially fish oil (rich in n-3 polyunsaturated fatty acids) were first described as effective dietary nutrients against hypertriglyceridemia but now are known to have positive effects on glucose metabolism as well.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.32 n.1 20142014-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000100046en10.4067/S0717-95022014000100046
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Animal models Nutritional induction Metabolic disease Type 2 diabetes mellitus
spellingShingle	Animal models Nutritional induction Metabolic disease Type 2 diabetes mellitus Barbosa-da-Silva,Sandra Sarmento,Isabele Bringhenti Bargut,Thereza C. Lonzetti Souza-Mello,Vanessa Aguila,Marcia Barbosa Mandarim-de-Lacerda,Carlos A Animal Models of Nutritional Induction of Type 2 Diabetes Mellitus
description	Type 2 diabetes mellitus (DM2) is the most common chronic metabolic disease, affecting approximately 6% of the adult population in the Western world. This condition is a major cause of cardiovascular disease, blindness, renal failure, and amputations, with increasing prevalence worldwide. The inuence of obesity on type 2 diabetes risk is determined by the degree of obesity and by body fat localization, with insulin resistance (IR) being the main link between these metabolic diseases. Experimental studies have shown that dietary factors, and particularly lipids, are strongly positively associated with body mass (BM) gain; IR; and, consequently, type 2 diabetes. Similarly, excessive consumption of energy-dense carbohydrate-rich foods can trigger the onset of type 2 diabetes. Additionally, maternal dietary inadequacies at conception and/or during the gestational period have been proposed to lead to developmental programming of excessive BM gain and metabolic disturbances in offspring, such as abnormal glucose homeostasis, reduced whole-body insulin sensitivity, impaired beta-cell insulin secretion and changes in the structure of the pancreas. Metabolic disruption is strongly associated with deleterious effects on beta-cell development and function. However, alterations in the amount and quality of dietary fat can modify glucose metabolism and insulin sensitivity. In this way, certain oils have gained attention in experimental research for their beneficial effects. Olive oil, a source of monounsaturated fatty acids (MUFAs), got attention in the past for its capacity to prevent cardiovascular diseases. Nevertheless, it is currently known that this oil also improves insulin sensitivity and glycemic control. Canola oil, flaxseed oil and especially fish oil (rich in n-3 polyunsaturated fatty acids) were first described as effective dietary nutrients against hypertriglyceridemia but now are known to have positive effects on glucose metabolism as well.
author	Barbosa-da-Silva,Sandra Sarmento,Isabele Bringhenti Bargut,Thereza C. Lonzetti Souza-Mello,Vanessa Aguila,Marcia Barbosa Mandarim-de-Lacerda,Carlos A
author_facet	Barbosa-da-Silva,Sandra Sarmento,Isabele Bringhenti Bargut,Thereza C. Lonzetti Souza-Mello,Vanessa Aguila,Marcia Barbosa Mandarim-de-Lacerda,Carlos A
author_sort	Barbosa-da-Silva,Sandra
title	Animal Models of Nutritional Induction of Type 2 Diabetes Mellitus
title_short	Animal Models of Nutritional Induction of Type 2 Diabetes Mellitus
title_full	Animal Models of Nutritional Induction of Type 2 Diabetes Mellitus
title_fullStr	Animal Models of Nutritional Induction of Type 2 Diabetes Mellitus
title_full_unstemmed	Animal Models of Nutritional Induction of Type 2 Diabetes Mellitus
title_sort	animal models of nutritional induction of type 2 diabetes mellitus
publisher	Sociedad Chilena de Anatomía
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000100046
work_keys_str_mv	AT barbosadasilvasandra animalmodelsofnutritionalinductionoftype2diabetesmellitus AT sarmentoisabelebringhenti animalmodelsofnutritionalinductionoftype2diabetesmellitus AT barguttherezaclonzetti animalmodelsofnutritionalinductionoftype2diabetesmellitus AT souzamellovanessa animalmodelsofnutritionalinductionoftype2diabetesmellitus AT aguilamarciabarbosa animalmodelsofnutritionalinductionoftype2diabetesmellitus AT mandarimdelacerdacarlosa animalmodelsofnutritionalinductionoftype2diabetesmellitus
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Animal Models of Nutritional Induction of Type 2 Diabetes Mellitus

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