Renal Corpuscles Were Protected From Dichlorvos: Induced Morphological Alterations in Rats by Antioxidant Vitamins

Dichlorvos (DDVP), an organophosphorus pesticide is a volatile compound which enters the human body through oral, dermal and inhalational routes and is excreted via the kidney. This study assessed the effects of DDVP on the histology of the kidney. Twenty five male rats (75.05 ± 5.55 g) were divided...

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Autores principales:	Owoeye,Olatunde, Edem,Fabian V, Akinyoola,Bukola S, Arinola,Ganiyu O
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2014
Materias:	Organophosphate Pesticide Glomerulus Renal corpuscle Vitamin- supplementation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000200017
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spelling	oai:scielo:S0717-950220140002000172015-11-16Renal Corpuscles Were Protected From Dichlorvos: Induced Morphological Alterations in Rats by Antioxidant VitaminsOwoeye,OlatundeEdem,Fabian VAkinyoola,Bukola SArinola,Ganiyu O Organophosphate Pesticide Glomerulus Renal corpuscle Vitamin- supplementation Dichlorvos (DDVP), an organophosphorus pesticide is a volatile compound which enters the human body through oral, dermal and inhalational routes and is excreted via the kidney. This study assessed the effects of DDVP on the histology of the kidney. Twenty five male rats (75.05 ± 5.55 g) were divided into 5 groups of 5 rats per group as follows: Unexposed group, exposure to DDVP alone for 5 weeks, and 3 other groups exposed to DDVP for 5 weeks in addition to supplement with Vitamin E, vitamin C, and red palm oil (RPO). Rats were exposed to DDVP in poorly ventilated cardboard cages for 4 hours daily. On completion of exposure, rats were euthanized and tissue processed by routine paraffin wax method and stained with H&E. Morphological alterations monitored by histological and morphometric studies using the graticule and software packages. Data were analyzed with ANOVA and p<0.05 considered as significant. DDVP caused significant reduction (10%) in the maximum glomerular diameter and 18% reduction in the maximum width of the renal corpuscle when compared with unexposed rats. However, VTE, VTC, and RPO significantly elevated the maximum glomerular diameter by 21%, 22%, 23% the respectively. Similarly, VTE, VTC, and RPO significantly elevated the maximum width of the renal corpuscle by 17%, 19%, 20% respectfully. Glomerular tuft cellularity was neither affected by DDVP treatment nor by vitamin augmentation. Inhaled DDVP caused histological alterations in the microscopic anatomy of renal corpuscles of rat which was mitigated by vitamin supplementation. Data suggest involvement of prolonged DDVP use in the aetiology of renal failure.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.32 n.2 20142014-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000200017en10.4067/S0717-95022014000200017
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Organophosphate Pesticide Glomerulus Renal corpuscle Vitamin- supplementation
spellingShingle	Organophosphate Pesticide Glomerulus Renal corpuscle Vitamin- supplementation Owoeye,Olatunde Edem,Fabian V Akinyoola,Bukola S Arinola,Ganiyu O Renal Corpuscles Were Protected From Dichlorvos: Induced Morphological Alterations in Rats by Antioxidant Vitamins
description	Dichlorvos (DDVP), an organophosphorus pesticide is a volatile compound which enters the human body through oral, dermal and inhalational routes and is excreted via the kidney. This study assessed the effects of DDVP on the histology of the kidney. Twenty five male rats (75.05 ± 5.55 g) were divided into 5 groups of 5 rats per group as follows: Unexposed group, exposure to DDVP alone for 5 weeks, and 3 other groups exposed to DDVP for 5 weeks in addition to supplement with Vitamin E, vitamin C, and red palm oil (RPO). Rats were exposed to DDVP in poorly ventilated cardboard cages for 4 hours daily. On completion of exposure, rats were euthanized and tissue processed by routine paraffin wax method and stained with H&E. Morphological alterations monitored by histological and morphometric studies using the graticule and software packages. Data were analyzed with ANOVA and p<0.05 considered as significant. DDVP caused significant reduction (10%) in the maximum glomerular diameter and 18% reduction in the maximum width of the renal corpuscle when compared with unexposed rats. However, VTE, VTC, and RPO significantly elevated the maximum glomerular diameter by 21%, 22%, 23% the respectively. Similarly, VTE, VTC, and RPO significantly elevated the maximum width of the renal corpuscle by 17%, 19%, 20% respectfully. Glomerular tuft cellularity was neither affected by DDVP treatment nor by vitamin augmentation. Inhaled DDVP caused histological alterations in the microscopic anatomy of renal corpuscles of rat which was mitigated by vitamin supplementation. Data suggest involvement of prolonged DDVP use in the aetiology of renal failure.
author	Owoeye,Olatunde Edem,Fabian V Akinyoola,Bukola S Arinola,Ganiyu O
author_facet	Owoeye,Olatunde Edem,Fabian V Akinyoola,Bukola S Arinola,Ganiyu O
author_sort	Owoeye,Olatunde
title	Renal Corpuscles Were Protected From Dichlorvos: Induced Morphological Alterations in Rats by Antioxidant Vitamins
title_short	Renal Corpuscles Were Protected From Dichlorvos: Induced Morphological Alterations in Rats by Antioxidant Vitamins
title_full	Renal Corpuscles Were Protected From Dichlorvos: Induced Morphological Alterations in Rats by Antioxidant Vitamins
title_fullStr	Renal Corpuscles Were Protected From Dichlorvos: Induced Morphological Alterations in Rats by Antioxidant Vitamins
title_full_unstemmed	Renal Corpuscles Were Protected From Dichlorvos: Induced Morphological Alterations in Rats by Antioxidant Vitamins
title_sort	renal corpuscles were protected from dichlorvos: induced morphological alterations in rats by antioxidant vitamins
publisher	Sociedad Chilena de Anatomía
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000200017
work_keys_str_mv	AT owoeyeolatunde renalcorpuscleswereprotectedfromdichlorvosinducedmorphologicalalterationsinratsbyantioxidantvitamins AT edemfabianv renalcorpuscleswereprotectedfromdichlorvosinducedmorphologicalalterationsinratsbyantioxidantvitamins AT akinyoolabukolas renalcorpuscleswereprotectedfromdichlorvosinducedmorphologicalalterationsinratsbyantioxidantvitamins AT arinolaganiyuo renalcorpuscleswereprotectedfromdichlorvosinducedmorphologicalalterationsinratsbyantioxidantvitamins
_version_	1718444869018451968

Renal Corpuscles Were Protected From Dichlorvos: Induced Morphological Alterations in Rats by Antioxidant Vitamins

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