Chemopreventive Effect of Brazilian Green Propolis on Experimental Dermal Carcinogenesis in Murine Model
The aim of this study was to assess the effect of oral administration of Hydroalcoholic Extract of Green Propolis (HEGP) on dermal carcinogenesis in rodent model. For the biological assay, we used 36 mice, assigned into 6 groups (n=6): CTR (treated with 100 mg/kg HEGP and no tumor induction), TUM (t...
Guardado en:
| Autores principales: | , , , , , , , , |
|---|---|
| Lenguaje: | English |
| Publicado: |
Sociedad Chilena de Anatomía
2014
|
| Materias: | |
| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000200024 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:scielo:S0717-95022014000200024 |
|---|---|
| record_format |
dspace |
| spelling |
oai:scielo:S0717-950220140002000242015-11-16Chemopreventive Effect of Brazilian Green Propolis on Experimental Dermal Carcinogenesis in Murine ModelPereira-Filho,Rose NelyBatista,Fellipe SantosRibeiro,Danielle RodriguesMelo,Genecy Calado deReis,Francisco PradoMelo,Allan Ulisses Carvalho deGomes,Margarete ZanardoCardoso,Juliana CordeiroAlbuquerque Júnior,Ricardo Luiz Cavalcanti de Propolis Skin cancer The aim of this study was to assess the effect of oral administration of Hydroalcoholic Extract of Green Propolis (HEGP) on dermal carcinogenesis in rodent model. For the biological assay, we used 36 mice, assigned into 6 groups (n=6): CTR (treated with 100 mg/kg HEGP and no tumor induction), TUM (treated with water and tumor induction), GP10 (treated with 10 mg/kg HEGP and tumor induction), GP50 (treated with 50 mg/kg HEGP and tumor induction) and GP100 (treated with 100 mg/kg HEGP and tumor induction). Cancer induction was performed in the back of the mice by topical application of DMBA. After 16 weeks, mice were euthanized and their backs were submitted to post-mortem histological analysis. The mean number of lesions developed in TUM (4.14±0.89) was significantly higher than in GP10 (2.05±1.02), GP50 (1.8±1.92) and GP100 (2.5±1.73) (p<0.05). The tumors formed in HEGP-treated groups were histologically more differentiated, but only in PV100 in situ lesions were evidenced. Infiltration of anatomical noble structures was less frequent in HEGP-treated groups (p<0.05). Our data suggest that oral administration of HEGP provided partial inhibition of DMBA-induced dermal carcinogenesis, as well as appeared to modulate the differentiation and infiltrative potential of the carcinomas in rodent model.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.32 n.2 20142014-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000200024en10.4067/S0717-95022014000200024 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Propolis Skin cancer |
| spellingShingle |
Propolis Skin cancer Pereira-Filho,Rose Nely Batista,Fellipe Santos Ribeiro,Danielle Rodrigues Melo,Genecy Calado de Reis,Francisco Prado Melo,Allan Ulisses Carvalho de Gomes,Margarete Zanardo Cardoso,Juliana Cordeiro Albuquerque Júnior,Ricardo Luiz Cavalcanti de Chemopreventive Effect of Brazilian Green Propolis on Experimental Dermal Carcinogenesis in Murine Model |
| description |
The aim of this study was to assess the effect of oral administration of Hydroalcoholic Extract of Green Propolis (HEGP) on dermal carcinogenesis in rodent model. For the biological assay, we used 36 mice, assigned into 6 groups (n=6): CTR (treated with 100 mg/kg HEGP and no tumor induction), TUM (treated with water and tumor induction), GP10 (treated with 10 mg/kg HEGP and tumor induction), GP50 (treated with 50 mg/kg HEGP and tumor induction) and GP100 (treated with 100 mg/kg HEGP and tumor induction). Cancer induction was performed in the back of the mice by topical application of DMBA. After 16 weeks, mice were euthanized and their backs were submitted to post-mortem histological analysis. The mean number of lesions developed in TUM (4.14±0.89) was significantly higher than in GP10 (2.05±1.02), GP50 (1.8±1.92) and GP100 (2.5±1.73) (p<0.05). The tumors formed in HEGP-treated groups were histologically more differentiated, but only in PV100 in situ lesions were evidenced. Infiltration of anatomical noble structures was less frequent in HEGP-treated groups (p<0.05). Our data suggest that oral administration of HEGP provided partial inhibition of DMBA-induced dermal carcinogenesis, as well as appeared to modulate the differentiation and infiltrative potential of the carcinomas in rodent model. |
| author |
Pereira-Filho,Rose Nely Batista,Fellipe Santos Ribeiro,Danielle Rodrigues Melo,Genecy Calado de Reis,Francisco Prado Melo,Allan Ulisses Carvalho de Gomes,Margarete Zanardo Cardoso,Juliana Cordeiro Albuquerque Júnior,Ricardo Luiz Cavalcanti de |
| author_facet |
Pereira-Filho,Rose Nely Batista,Fellipe Santos Ribeiro,Danielle Rodrigues Melo,Genecy Calado de Reis,Francisco Prado Melo,Allan Ulisses Carvalho de Gomes,Margarete Zanardo Cardoso,Juliana Cordeiro Albuquerque Júnior,Ricardo Luiz Cavalcanti de |
| author_sort |
Pereira-Filho,Rose Nely |
| title |
Chemopreventive Effect of Brazilian Green Propolis on Experimental Dermal Carcinogenesis in Murine Model |
| title_short |
Chemopreventive Effect of Brazilian Green Propolis on Experimental Dermal Carcinogenesis in Murine Model |
| title_full |
Chemopreventive Effect of Brazilian Green Propolis on Experimental Dermal Carcinogenesis in Murine Model |
| title_fullStr |
Chemopreventive Effect of Brazilian Green Propolis on Experimental Dermal Carcinogenesis in Murine Model |
| title_full_unstemmed |
Chemopreventive Effect of Brazilian Green Propolis on Experimental Dermal Carcinogenesis in Murine Model |
| title_sort |
chemopreventive effect of brazilian green propolis on experimental dermal carcinogenesis in murine model |
| publisher |
Sociedad Chilena de Anatomía |
| publishDate |
2014 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000200024 |
| work_keys_str_mv |
AT pereirafilhorosenely chemopreventiveeffectofbraziliangreenpropolisonexperimentaldermalcarcinogenesisinmurinemodel AT batistafellipesantos chemopreventiveeffectofbraziliangreenpropolisonexperimentaldermalcarcinogenesisinmurinemodel AT ribeirodaniellerodrigues chemopreventiveeffectofbraziliangreenpropolisonexperimentaldermalcarcinogenesisinmurinemodel AT melogenecycaladode chemopreventiveeffectofbraziliangreenpropolisonexperimentaldermalcarcinogenesisinmurinemodel AT reisfranciscoprado chemopreventiveeffectofbraziliangreenpropolisonexperimentaldermalcarcinogenesisinmurinemodel AT meloallanulissescarvalhode chemopreventiveeffectofbraziliangreenpropolisonexperimentaldermalcarcinogenesisinmurinemodel AT gomesmargaretezanardo chemopreventiveeffectofbraziliangreenpropolisonexperimentaldermalcarcinogenesisinmurinemodel AT cardosojulianacordeiro chemopreventiveeffectofbraziliangreenpropolisonexperimentaldermalcarcinogenesisinmurinemodel AT albuquerquejuniorricardoluizcavalcantide chemopreventiveeffectofbraziliangreenpropolisonexperimentaldermalcarcinogenesisinmurinemodel |
| _version_ |
1718444870377406464 |