Repeated Binge-Like Ethanol Administration During Adolescence cause Decreased C-Fos Immunoreactivity in Amygdala and Arcuate Nucleus in Adult Sprague-Dawley Rats
Binge alcohol drinking during adolescence has been associated with neurotoxicity and increased risk for the development of alcohol use disorders. There is evidence that acute and chronic ethanol administration alters c-fos expression, an indirect index of cellular activity, in different brain region...
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Sociedad Chilena de Anatomía
2014
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oai:scielo:S0717-950220140002000332015-11-16Repeated Binge-Like Ethanol Administration During Adolescence cause Decreased C-Fos Immunoreactivity in Amygdala and Arcuate Nucleus in Adult Sprague-Dawley RatsLerma-Cabrera,Jose ManuelCarvajal,FranciscaAlcaraz-Iborra,ManuelSanchez-Amate,Maria del Carmende la Fuente,LeticiaCubero,Inmaculada -Fos Immunoreactivity Rats Binge-like ethanol administration Adolescent Arcuate nucleus of hypothalamus (Arc) Central nucleus of the amygdala (CeA) Paraventricular nucleus of the hypothalamus (PVN) Binge alcohol drinking during adolescence has been associated with neurotoxicity and increased risk for the development of alcohol use disorders. There is evidence that acute and chronic ethanol administration alters c-fos expression, an indirect index of cellular activity, in different brain regions in adult rats. We evaluate here if a binge-like pattern of ethanol exposure during adolescence has a relevant impact on basal and/or ethanol-stimulated regional c-fos activity during adulthood. For that aim, Sprague-Dawley rats PND 25 were saline pre-treated, (SP group) or binge-ethanol pre-treated (BEP group) for twoconsecutive days, at 48-h intervals, over a 14-day period (PND 25 to PND 38). At adult stage (PND 63) and following 25 ethanol-free days, we evaluated c-fos immunoreactivity in response to saline or acute ethanol (1.5 or 3.0 g/kg) in the hypothalamus and amygdala. We found that acute ethanol administration dose-dependently increased c-fos activity in the the Paraventricular nucleus of the hypothalamus (PVN). Interestingly, binge-ethanol exposure during adolescence significantly reduced basal c-fos activity during adulthood in the Central nucleus of the amygdala (CeA) and the Arcuate nucleus of hypothalamus (Arc). We conclude that binge-like ethanol administration during adolescence causes long-term disturbances in basal neural activity in brain areas critically involved with ethanol consumption.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.32 n.2 20142014-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000200033en10.4067/S0717-95022014000200033 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
-Fos Immunoreactivity Rats Binge-like ethanol administration Adolescent Arcuate nucleus of hypothalamus (Arc) Central nucleus of the amygdala (CeA) Paraventricular nucleus of the hypothalamus (PVN) |
| spellingShingle |
-Fos Immunoreactivity Rats Binge-like ethanol administration Adolescent Arcuate nucleus of hypothalamus (Arc) Central nucleus of the amygdala (CeA) Paraventricular nucleus of the hypothalamus (PVN) Lerma-Cabrera,Jose Manuel Carvajal,Francisca Alcaraz-Iborra,Manuel Sanchez-Amate,Maria del Carmen de la Fuente,Leticia Cubero,Inmaculada Repeated Binge-Like Ethanol Administration During Adolescence cause Decreased C-Fos Immunoreactivity in Amygdala and Arcuate Nucleus in Adult Sprague-Dawley Rats |
| description |
Binge alcohol drinking during adolescence has been associated with neurotoxicity and increased risk for the development of alcohol use disorders. There is evidence that acute and chronic ethanol administration alters c-fos expression, an indirect index of cellular activity, in different brain regions in adult rats. We evaluate here if a binge-like pattern of ethanol exposure during adolescence has a relevant impact on basal and/or ethanol-stimulated regional c-fos activity during adulthood. For that aim, Sprague-Dawley rats PND 25 were saline pre-treated, (SP group) or binge-ethanol pre-treated (BEP group) for twoconsecutive days, at 48-h intervals, over a 14-day period (PND 25 to PND 38). At adult stage (PND 63) and following 25 ethanol-free days, we evaluated c-fos immunoreactivity in response to saline or acute ethanol (1.5 or 3.0 g/kg) in the hypothalamus and amygdala. We found that acute ethanol administration dose-dependently increased c-fos activity in the the Paraventricular nucleus of the hypothalamus (PVN). Interestingly, binge-ethanol exposure during adolescence significantly reduced basal c-fos activity during adulthood in the Central nucleus of the amygdala (CeA) and the Arcuate nucleus of hypothalamus (Arc). We conclude that binge-like ethanol administration during adolescence causes long-term disturbances in basal neural activity in brain areas critically involved with ethanol consumption. |
| author |
Lerma-Cabrera,Jose Manuel Carvajal,Francisca Alcaraz-Iborra,Manuel Sanchez-Amate,Maria del Carmen de la Fuente,Leticia Cubero,Inmaculada |
| author_facet |
Lerma-Cabrera,Jose Manuel Carvajal,Francisca Alcaraz-Iborra,Manuel Sanchez-Amate,Maria del Carmen de la Fuente,Leticia Cubero,Inmaculada |
| author_sort |
Lerma-Cabrera,Jose Manuel |
| title |
Repeated Binge-Like Ethanol Administration During Adolescence cause Decreased C-Fos Immunoreactivity in Amygdala and Arcuate Nucleus in Adult Sprague-Dawley Rats |
| title_short |
Repeated Binge-Like Ethanol Administration During Adolescence cause Decreased C-Fos Immunoreactivity in Amygdala and Arcuate Nucleus in Adult Sprague-Dawley Rats |
| title_full |
Repeated Binge-Like Ethanol Administration During Adolescence cause Decreased C-Fos Immunoreactivity in Amygdala and Arcuate Nucleus in Adult Sprague-Dawley Rats |
| title_fullStr |
Repeated Binge-Like Ethanol Administration During Adolescence cause Decreased C-Fos Immunoreactivity in Amygdala and Arcuate Nucleus in Adult Sprague-Dawley Rats |
| title_full_unstemmed |
Repeated Binge-Like Ethanol Administration During Adolescence cause Decreased C-Fos Immunoreactivity in Amygdala and Arcuate Nucleus in Adult Sprague-Dawley Rats |
| title_sort |
repeated binge-like ethanol administration during adolescence cause decreased c-fos immunoreactivity in amygdala and arcuate nucleus in adult sprague-dawley rats |
| publisher |
Sociedad Chilena de Anatomía |
| publishDate |
2014 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000200033 |
| work_keys_str_mv |
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