Histomorphometric Evaluation of Soleus and Lateral Gastrocnemius Muscles of Animals Submitted to Pharmacological Manipulation with Fluoxetine

The pharmacological manipulation with selective inhibitor of serotonin reuptake (SSRIs) can modify the operation of the serotonergic system and may facilitate or inhibit the action of this system, inducing changes in the morphology of the skeletal muscle of rats. The objective of this study was to e...

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Autores principales:	Caiaffo,Vitor, Ribeiro,Alice Sá Carneiro, de Oliveira,Belisa Duarte Ribeiro, de Albuquerque,Yuri Mateus Lima, de Moraes,Silvia Regina Arruda
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2014
Materias:	Fluoxetine Muscles Fiber Skeletal Muscle Myonuclei Cross Section Area
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000300001
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spelling	oai:scielo:S0717-950220140003000012015-11-16Histomorphometric Evaluation of Soleus and Lateral Gastrocnemius Muscles of Animals Submitted to Pharmacological Manipulation with FluoxetineCaiaffo,VitorRibeiro,Alice Sá Carneirode Oliveira,Belisa Duarte Ribeirode Albuquerque,Yuri Mateus Limade Moraes,Silvia Regina Arruda Fluoxetine Muscles Fiber Skeletal Muscle Myonuclei Cross Section Area The pharmacological manipulation with selective inhibitor of serotonin reuptake (SSRIs) can modify the operation of the serotonergic system and may facilitate or inhibit the action of this system, inducing changes in the morphology of the skeletal muscle of rats. The objective of this study was to evaluate the action of the treatment with fluoxetine during the critical period of the animal´s life on development of the soleus and lateral gastrocnemius muscles, under the aspects of weight, the number of nuclei of myocyte cells and cross-sectional area of muscle fibers. Twenty four (30 and 90-day-old) male Wistar rats were used. They were treated with saline solution (NaCl 0.9%; 1 ml/100 g of body weight) or fluoxetine (10 mg; 1 ml/100g of body weight). The animals were divided in Saline Group (GS-30 and GS-90) and Fluoxetine Group (GF-30 and GF-90). The fluoxetine group showed a reduction on weight (g) of soleus (p=0.046) and lateral gastrocnemius (p=0.02) muscles in rats with 90 days. A lesser number of myonuclei was observed in fluoxetine group than saline group of 30 days (soleus, p<0.001; lateral gastrocnemius, p0.007) and 90 days (soleus, p=0.002; lateral gastrocnemius, p0.038). The cross section area of fluoxetine groups is also smaller than the saline groups with 30 days (soleus, p=0.03; lateral gastrocnemius, p=0.041) and 90 days (soleus, p=0.042; lateral gastrocnemius, p=0.012). The treatment of fluoxetine during the critical period of development of the nervous system of rats, causes early changes in the structure of muscle fibers that seem to be related to reducing the weight of the soleus and gastrocnemius muscles only in late stage of the animal's life. Thus, the dosage used ISRS, suggests an inhibitory effect of 5-HT in relation to variables on the development of the skeletal muscle tissue of rats.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.32 n.3 20142014-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000300001en10.4067/S0717-95022014000300001
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Fluoxetine Muscles Fiber Skeletal Muscle Myonuclei Cross Section Area
spellingShingle	Fluoxetine Muscles Fiber Skeletal Muscle Myonuclei Cross Section Area Caiaffo,Vitor Ribeiro,Alice Sá Carneiro de Oliveira,Belisa Duarte Ribeiro de Albuquerque,Yuri Mateus Lima de Moraes,Silvia Regina Arruda Histomorphometric Evaluation of Soleus and Lateral Gastrocnemius Muscles of Animals Submitted to Pharmacological Manipulation with Fluoxetine
description	The pharmacological manipulation with selective inhibitor of serotonin reuptake (SSRIs) can modify the operation of the serotonergic system and may facilitate or inhibit the action of this system, inducing changes in the morphology of the skeletal muscle of rats. The objective of this study was to evaluate the action of the treatment with fluoxetine during the critical period of the animal´s life on development of the soleus and lateral gastrocnemius muscles, under the aspects of weight, the number of nuclei of myocyte cells and cross-sectional area of muscle fibers. Twenty four (30 and 90-day-old) male Wistar rats were used. They were treated with saline solution (NaCl 0.9%; 1 ml/100 g of body weight) or fluoxetine (10 mg; 1 ml/100g of body weight). The animals were divided in Saline Group (GS-30 and GS-90) and Fluoxetine Group (GF-30 and GF-90). The fluoxetine group showed a reduction on weight (g) of soleus (p=0.046) and lateral gastrocnemius (p=0.02) muscles in rats with 90 days. A lesser number of myonuclei was observed in fluoxetine group than saline group of 30 days (soleus, p<0.001; lateral gastrocnemius, p0.007) and 90 days (soleus, p=0.002; lateral gastrocnemius, p0.038). The cross section area of fluoxetine groups is also smaller than the saline groups with 30 days (soleus, p=0.03; lateral gastrocnemius, p=0.041) and 90 days (soleus, p=0.042; lateral gastrocnemius, p=0.012). The treatment of fluoxetine during the critical period of development of the nervous system of rats, causes early changes in the structure of muscle fibers that seem to be related to reducing the weight of the soleus and gastrocnemius muscles only in late stage of the animal's life. Thus, the dosage used ISRS, suggests an inhibitory effect of 5-HT in relation to variables on the development of the skeletal muscle tissue of rats.
author	Caiaffo,Vitor Ribeiro,Alice Sá Carneiro de Oliveira,Belisa Duarte Ribeiro de Albuquerque,Yuri Mateus Lima de Moraes,Silvia Regina Arruda
author_facet	Caiaffo,Vitor Ribeiro,Alice Sá Carneiro de Oliveira,Belisa Duarte Ribeiro de Albuquerque,Yuri Mateus Lima de Moraes,Silvia Regina Arruda
author_sort	Caiaffo,Vitor
title	Histomorphometric Evaluation of Soleus and Lateral Gastrocnemius Muscles of Animals Submitted to Pharmacological Manipulation with Fluoxetine
title_short	Histomorphometric Evaluation of Soleus and Lateral Gastrocnemius Muscles of Animals Submitted to Pharmacological Manipulation with Fluoxetine
title_full	Histomorphometric Evaluation of Soleus and Lateral Gastrocnemius Muscles of Animals Submitted to Pharmacological Manipulation with Fluoxetine
title_fullStr	Histomorphometric Evaluation of Soleus and Lateral Gastrocnemius Muscles of Animals Submitted to Pharmacological Manipulation with Fluoxetine
title_full_unstemmed	Histomorphometric Evaluation of Soleus and Lateral Gastrocnemius Muscles of Animals Submitted to Pharmacological Manipulation with Fluoxetine
title_sort	histomorphometric evaluation of soleus and lateral gastrocnemius muscles of animals submitted to pharmacological manipulation with fluoxetine
publisher	Sociedad Chilena de Anatomía
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000300001
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Histomorphometric Evaluation of Soleus and Lateral Gastrocnemius Muscles of Animals Submitted to Pharmacological Manipulation with Fluoxetine

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