Use of Anabolic Steroid Altered the Liver Morphology of Rats

The aim of this research was to investigate the effect of testosterone propionate administration in the liver of rats. The rats were divided in the following groups: Initial control (SC), Aged control (SE) and Anabolic group (SA). Testosterone propionate was administered three times per week during...

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Autores principales:	Tanasov,Valéria Simões, Neto,Walter Krause, Gonçalves,Leandro, Maifrino,Laura Beatriz Mesiano, de Sousa,Romeu Rodrigues, Gama,Eliane Florencio
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2014
Materias:	Aging Testosterone proprionate Hepatic tissue Animals
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000300002
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spelling	oai:scielo:S0717-950220140003000022015-11-16Use of Anabolic Steroid Altered the Liver Morphology of RatsTanasov,Valéria SimõesNeto,Walter KrauseGonçalves,LeandroMaifrino,Laura Beatriz Mesianode Sousa,Romeu RodriguesGama,Eliane Florencio Aging Testosterone proprionate Hepatic tissue Animals The aim of this research was to investigate the effect of testosterone propionate administration in the liver of rats. The rats were divided in the following groups: Initial control (SC), Aged control (SE) and Anabolic group (SA). Testosterone propionate was administered three times per week during 16 weeks. Using morphoquantitative techniques, we quantified the volume densities of lobular and non-lobular parenchyma, area and number of nuclei of hepatocytes. The data were analyzed statistically using mean and standard deviation, ANOVA one-way and level of significance about p0.05. Our results showed an increase in capillaries, perisinusoidal spaces and biliary ducts in SE group compared to SC. SA group showed a decrease in hepatic cells, non-lobular volume density and hepatocytes nuclei area, but also an increase in capillaries, perisinusoidal spaces, biliary ducts, number of hepatocytes and non-hepatocyte nuclei compared to SC. We conclude that a direct toxicity may have occurred, with consequent loss of the cells.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.32 n.3 20142014-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000300002en10.4067/S0717-95022014000300002
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Aging Testosterone proprionate Hepatic tissue Animals
spellingShingle	Aging Testosterone proprionate Hepatic tissue Animals Tanasov,Valéria Simões Neto,Walter Krause Gonçalves,Leandro Maifrino,Laura Beatriz Mesiano de Sousa,Romeu Rodrigues Gama,Eliane Florencio Use of Anabolic Steroid Altered the Liver Morphology of Rats
description	The aim of this research was to investigate the effect of testosterone propionate administration in the liver of rats. The rats were divided in the following groups: Initial control (SC), Aged control (SE) and Anabolic group (SA). Testosterone propionate was administered three times per week during 16 weeks. Using morphoquantitative techniques, we quantified the volume densities of lobular and non-lobular parenchyma, area and number of nuclei of hepatocytes. The data were analyzed statistically using mean and standard deviation, ANOVA one-way and level of significance about p0.05. Our results showed an increase in capillaries, perisinusoidal spaces and biliary ducts in SE group compared to SC. SA group showed a decrease in hepatic cells, non-lobular volume density and hepatocytes nuclei area, but also an increase in capillaries, perisinusoidal spaces, biliary ducts, number of hepatocytes and non-hepatocyte nuclei compared to SC. We conclude that a direct toxicity may have occurred, with consequent loss of the cells.
author	Tanasov,Valéria Simões Neto,Walter Krause Gonçalves,Leandro Maifrino,Laura Beatriz Mesiano de Sousa,Romeu Rodrigues Gama,Eliane Florencio
author_facet	Tanasov,Valéria Simões Neto,Walter Krause Gonçalves,Leandro Maifrino,Laura Beatriz Mesiano de Sousa,Romeu Rodrigues Gama,Eliane Florencio
author_sort	Tanasov,Valéria Simões
title	Use of Anabolic Steroid Altered the Liver Morphology of Rats
title_short	Use of Anabolic Steroid Altered the Liver Morphology of Rats
title_full	Use of Anabolic Steroid Altered the Liver Morphology of Rats
title_fullStr	Use of Anabolic Steroid Altered the Liver Morphology of Rats
title_full_unstemmed	Use of Anabolic Steroid Altered the Liver Morphology of Rats
title_sort	use of anabolic steroid altered the liver morphology of rats
publisher	Sociedad Chilena de Anatomía
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000300002
work_keys_str_mv	AT tanasovvaleriasimoes useofanabolicsteroidalteredthelivermorphologyofrats AT netowalterkrause useofanabolicsteroidalteredthelivermorphologyofrats AT goncalvesleandro useofanabolicsteroidalteredthelivermorphologyofrats AT maifrinolaurabeatrizmesiano useofanabolicsteroidalteredthelivermorphologyofrats AT desousaromeurodrigues useofanabolicsteroidalteredthelivermorphologyofrats AT gamaelianeflorencio useofanabolicsteroidalteredthelivermorphologyofrats
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Use of Anabolic Steroid Altered the Liver Morphology of Rats

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