Morphometrical Analysis of the Effect of Nicotine Administration on Brain's Prefrontal Region in Male Rat

Nicotine is the most important alkaloid compound in tobacco. One of the major effects of nicotine is stimulation of mesocorticolimbic system. Prefrontal cortex plays a pivotal role in personality and mental state. It is considered the main cause of addiction as it is located in mesocorticolimbic dop...

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Autores principales:	Jalili,C, Salahshoor,M. R, Khademi,F, Jalili,P, Roshankhah,S. H
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2014
Materias:	Morphometric Prefrontal cortex Nicotine Rat
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000300003
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spelling	oai:scielo:S0717-950220140003000032015-11-16Morphometrical Analysis of the Effect of Nicotine Administration on Brain's Prefrontal Region in Male RatJalili,CSalahshoor,M. RKhademi,FJalili,PRoshankhah,S. H Morphometric Prefrontal cortex Nicotine Rat Nicotine is the most important alkaloid compound in tobacco. One of the major effects of nicotine is stimulation of mesocorticolimbic system. Prefrontal cortex plays a pivotal role in personality and mental state. It is considered the main cause of addiction as it is located in mesocorticolimbic dopamine system. Twenty four male rats were divided into four groups based on nicotine administration dose (0, 0.5, 1 and 1.5 g/kg). After animals were anesthetized, their brains were fixed using transcardiac method. Tissue processing and Golgi staining were performed and the stained tissue sections were analyzed by optic microscope and Motic software. By increasing the dose, nicotine significantly decreased the number of neuronal processes. In the higher dose, nicotine caused a significant decrease and increase in the size of pericarions and dendritic spines, respectively (p<0.05). Nicotine administration can decrease the size of pericarion and number of dendritic spines in the prefrontal cortex.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.32 n.3 20142014-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000300003en10.4067/S0717-95022014000300003
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Morphometric Prefrontal cortex Nicotine Rat
spellingShingle	Morphometric Prefrontal cortex Nicotine Rat Jalili,C Salahshoor,M. R Khademi,F Jalili,P Roshankhah,S. H Morphometrical Analysis of the Effect of Nicotine Administration on Brain's Prefrontal Region in Male Rat
description	Nicotine is the most important alkaloid compound in tobacco. One of the major effects of nicotine is stimulation of mesocorticolimbic system. Prefrontal cortex plays a pivotal role in personality and mental state. It is considered the main cause of addiction as it is located in mesocorticolimbic dopamine system. Twenty four male rats were divided into four groups based on nicotine administration dose (0, 0.5, 1 and 1.5 g/kg). After animals were anesthetized, their brains were fixed using transcardiac method. Tissue processing and Golgi staining were performed and the stained tissue sections were analyzed by optic microscope and Motic software. By increasing the dose, nicotine significantly decreased the number of neuronal processes. In the higher dose, nicotine caused a significant decrease and increase in the size of pericarions and dendritic spines, respectively (p<0.05). Nicotine administration can decrease the size of pericarion and number of dendritic spines in the prefrontal cortex.
author	Jalili,C Salahshoor,M. R Khademi,F Jalili,P Roshankhah,S. H
author_facet	Jalili,C Salahshoor,M. R Khademi,F Jalili,P Roshankhah,S. H
author_sort	Jalili,C
title	Morphometrical Analysis of the Effect of Nicotine Administration on Brain's Prefrontal Region in Male Rat
title_short	Morphometrical Analysis of the Effect of Nicotine Administration on Brain's Prefrontal Region in Male Rat
title_full	Morphometrical Analysis of the Effect of Nicotine Administration on Brain's Prefrontal Region in Male Rat
title_fullStr	Morphometrical Analysis of the Effect of Nicotine Administration on Brain's Prefrontal Region in Male Rat
title_full_unstemmed	Morphometrical Analysis of the Effect of Nicotine Administration on Brain's Prefrontal Region in Male Rat
title_sort	morphometrical analysis of the effect of nicotine administration on brain's prefrontal region in male rat
publisher	Sociedad Chilena de Anatomía
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000300003
work_keys_str_mv	AT jalilic morphometricalanalysisoftheeffectofnicotineadministrationonbrainsprefrontalregioninmalerat AT salahshoormr morphometricalanalysisoftheeffectofnicotineadministrationonbrainsprefrontalregioninmalerat AT khademif morphometricalanalysisoftheeffectofnicotineadministrationonbrainsprefrontalregioninmalerat AT jalilip morphometricalanalysisoftheeffectofnicotineadministrationonbrainsprefrontalregioninmalerat AT roshankhahsh morphometricalanalysisoftheeffectofnicotineadministrationonbrainsprefrontalregioninmalerat
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Morphometrical Analysis of the Effect of Nicotine Administration on Brain's Prefrontal Region in Male Rat

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