Protective Effect of Curcumin Against Nicotine-induced Damage on Reproductive Parameters in Male Mice

Nicotine consumption can decrease fertility drive in males through inducing oxidative stress and DNA damage. The color of turmeric is because of a substance called curcumin for which some anti-oxidative and anti-inflammatory properties have been identified. In this study, various doses of curcumin (...

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Autores principales:	Jalili,C, Khani,F, Salahshoor,M. R, Roshankhah,S
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2014
Materias:	Curcumin Nicotine Reproductive Parameters Mice
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000300017
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spelling	oai:scielo:S0717-950220140003000172015-11-16Protective Effect of Curcumin Against Nicotine-induced Damage on Reproductive Parameters in Male MiceJalili,CKhani,FSalahshoor,M. RRoshankhah,S Curcumin Nicotine Reproductive Parameters Mice Nicotine consumption can decrease fertility drive in males through inducing oxidative stress and DNA damage. The color of turmeric is because of a substance called curcumin for which some anti-oxidative and anti-inflammatory properties have been identified. In this study, various doses of curcumin (10, 30 and 60 mg/kg) and curcumin plus nicotine (10, 30 and 60 mg/kg) were administered intraperitoneally to male mice for 28 consequent days and reproductive parameters were determined. The results indicated that nicotine administration (0.5 mg/kg) significantly decreased testosterone level, count and motility of sperms, and testis weight compared to control group. However, increasing the dose of curcumin significantly increased reproductive indices in most of the groups. Thus, it seems that curcumin inhibits nicotine-induced adverse effects on reproductive parameters.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.32 n.3 20142014-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000300017en10.4067/S0717-95022014000300017
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Curcumin Nicotine Reproductive Parameters Mice
spellingShingle	Curcumin Nicotine Reproductive Parameters Mice Jalili,C Khani,F Salahshoor,M. R Roshankhah,S Protective Effect of Curcumin Against Nicotine-induced Damage on Reproductive Parameters in Male Mice
description	Nicotine consumption can decrease fertility drive in males through inducing oxidative stress and DNA damage. The color of turmeric is because of a substance called curcumin for which some anti-oxidative and anti-inflammatory properties have been identified. In this study, various doses of curcumin (10, 30 and 60 mg/kg) and curcumin plus nicotine (10, 30 and 60 mg/kg) were administered intraperitoneally to male mice for 28 consequent days and reproductive parameters were determined. The results indicated that nicotine administration (0.5 mg/kg) significantly decreased testosterone level, count and motility of sperms, and testis weight compared to control group. However, increasing the dose of curcumin significantly increased reproductive indices in most of the groups. Thus, it seems that curcumin inhibits nicotine-induced adverse effects on reproductive parameters.
author	Jalili,C Khani,F Salahshoor,M. R Roshankhah,S
author_facet	Jalili,C Khani,F Salahshoor,M. R Roshankhah,S
author_sort	Jalili,C
title	Protective Effect of Curcumin Against Nicotine-induced Damage on Reproductive Parameters in Male Mice
title_short	Protective Effect of Curcumin Against Nicotine-induced Damage on Reproductive Parameters in Male Mice
title_full	Protective Effect of Curcumin Against Nicotine-induced Damage on Reproductive Parameters in Male Mice
title_fullStr	Protective Effect of Curcumin Against Nicotine-induced Damage on Reproductive Parameters in Male Mice
title_full_unstemmed	Protective Effect of Curcumin Against Nicotine-induced Damage on Reproductive Parameters in Male Mice
title_sort	protective effect of curcumin against nicotine-induced damage on reproductive parameters in male mice
publisher	Sociedad Chilena de Anatomía
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000300017
work_keys_str_mv	AT jalilic protectiveeffectofcurcuminagainstnicotineinduceddamageonreproductiveparametersinmalemice AT khanif protectiveeffectofcurcuminagainstnicotineinduceddamageonreproductiveparametersinmalemice AT salahshoormr protectiveeffectofcurcuminagainstnicotineinduceddamageonreproductiveparametersinmalemice AT roshankhahs protectiveeffectofcurcuminagainstnicotineinduceddamageonreproductiveparametersinmalemice
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Protective Effect of Curcumin Against Nicotine-induced Damage on Reproductive Parameters in Male Mice

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