Effects of Monocular Deprivation on the Dendritic Features of Retinal Ganglion Cells

Monocular deprivation results in anatomical changes in the visual cortex in favor of the non-deprived eye. Although the retina forms part of the visual pathway, there is scarcity of data on the effect of monocular deprivation on its structure. The objective of this study was to describe the effects...

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Autores principales:	Mwachaka,Philip, Saidi,Hassan, Odula,Paul, Mandela,Pamela
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2014
Materias:	Monocular deprivation Retina Retinal Ganglion Cells Dendritic features Eye
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000400004
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spelling	oai:scielo:S0717-950220140004000042015-11-16Effects of Monocular Deprivation on the Dendritic Features of Retinal Ganglion CellsMwachaka,PhilipSaidi,HassanOdula,PaulMandela,Pamela Monocular deprivation Retina Retinal Ganglion Cells Dendritic features Eye Monocular deprivation results in anatomical changes in the visual cortex in favor of the non-deprived eye. Although the retina forms part of the visual pathway, there is scarcity of data on the effect of monocular deprivation on its structure. The objective of this study was to describe the effects of monocular deprivation on the retinal ganglion cell dendritic features. The study design was quasi-experimental. 30 rabbits (18 experimental, 12 controls) were examined. Monocular deprivation was achieved through unilateral lid suture in the experimental animals. The rabbits were observed for three weeks. Each week, 6 experimental and 3 control animals were euthanized, their retina harvested and processed for light microscopy. Photomicrographs of the retina were taken using a digital camera then entered into FIJI software for analysis. The number of primary branches, terminal branches and dendritic field area among the non-deprived eyes increased by 66.7%(p=0.385), 400%(p=0.002), and 88.4%(p=0.523) respectively. Non-deprived eyes had 114.3% more terminal dendrites (p=0.002) compared to controls. Among deprived eyes, all variables measured had a gradual rise in the first two weeks followed by decline with further deprivation. There were no statistically significant differences noted between the deprived and control eyes. Monocular deprivation results in increase in synaptic contacts in the non-deprived eye, with reciprocal changes occurring in the deprived eye.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.32 n.4 20142014-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000400004en10.4067/S0717-95022014000400004
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Monocular deprivation Retina Retinal Ganglion Cells Dendritic features Eye
spellingShingle	Monocular deprivation Retina Retinal Ganglion Cells Dendritic features Eye Mwachaka,Philip Saidi,Hassan Odula,Paul Mandela,Pamela Effects of Monocular Deprivation on the Dendritic Features of Retinal Ganglion Cells
description	Monocular deprivation results in anatomical changes in the visual cortex in favor of the non-deprived eye. Although the retina forms part of the visual pathway, there is scarcity of data on the effect of monocular deprivation on its structure. The objective of this study was to describe the effects of monocular deprivation on the retinal ganglion cell dendritic features. The study design was quasi-experimental. 30 rabbits (18 experimental, 12 controls) were examined. Monocular deprivation was achieved through unilateral lid suture in the experimental animals. The rabbits were observed for three weeks. Each week, 6 experimental and 3 control animals were euthanized, their retina harvested and processed for light microscopy. Photomicrographs of the retina were taken using a digital camera then entered into FIJI software for analysis. The number of primary branches, terminal branches and dendritic field area among the non-deprived eyes increased by 66.7%(p=0.385), 400%(p=0.002), and 88.4%(p=0.523) respectively. Non-deprived eyes had 114.3% more terminal dendrites (p=0.002) compared to controls. Among deprived eyes, all variables measured had a gradual rise in the first two weeks followed by decline with further deprivation. There were no statistically significant differences noted between the deprived and control eyes. Monocular deprivation results in increase in synaptic contacts in the non-deprived eye, with reciprocal changes occurring in the deprived eye.
author	Mwachaka,Philip Saidi,Hassan Odula,Paul Mandela,Pamela
author_facet	Mwachaka,Philip Saidi,Hassan Odula,Paul Mandela,Pamela
author_sort	Mwachaka,Philip
title	Effects of Monocular Deprivation on the Dendritic Features of Retinal Ganglion Cells
title_short	Effects of Monocular Deprivation on the Dendritic Features of Retinal Ganglion Cells
title_full	Effects of Monocular Deprivation on the Dendritic Features of Retinal Ganglion Cells
title_fullStr	Effects of Monocular Deprivation on the Dendritic Features of Retinal Ganglion Cells
title_full_unstemmed	Effects of Monocular Deprivation on the Dendritic Features of Retinal Ganglion Cells
title_sort	effects of monocular deprivation on the dendritic features of retinal ganglion cells
publisher	Sociedad Chilena de Anatomía
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000400004
work_keys_str_mv	AT mwachakaphilip effectsofmonoculardeprivationonthedendriticfeaturesofretinalganglioncells AT saidihassan effectsofmonoculardeprivationonthedendriticfeaturesofretinalganglioncells AT odulapaul effectsofmonoculardeprivationonthedendriticfeaturesofretinalganglioncells AT mandelapamela effectsofmonoculardeprivationonthedendriticfeaturesofretinalganglioncells
_version_	1718444888521965568

Effects of Monocular Deprivation on the Dendritic Features of Retinal Ganglion Cells

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