Comparison of Proliferative Activity of Epithelial Cells between the Follicles of Impacted Teeth

The aim of this comparative observational study was to compare the proliferative activity of dental follicles surrounding impacted maxillary canines and mandibular third molars. Following extraction, forty follicles of the impacted mandibular third molars and 40 follicles of the impacted maxillary c...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kömerik,Nurgül, Tufan,Alper, Kapucuoglu,Nilgün
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2014
Materias:	Dental follicle Ki-67 MCM-2 EGFR Immunohistochemistry
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000400028
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-95022014000400028
record_format	dspace
spelling	oai:scielo:S0717-950220140004000282015-11-16Comparison of Proliferative Activity of Epithelial Cells between the Follicles of Impacted TeethKömerik,NurgülTufan,AlperKapucuoglu,Nilgün Dental follicle Ki-67 MCM-2 EGFR Immunohistochemistry The aim of this comparative observational study was to compare the proliferative activity of dental follicles surrounding impacted maxillary canines and mandibular third molars. Following extraction, forty follicles of the impacted mandibular third molars and 40 follicles of the impacted maxillary canines were removed. Epithelial cell proliferative activity of these samples was assessed using immunohistochemical labeling for Ki-67, minichromosome maintenance 2 (MCM-2) protein and epithelial growth factor receptor (EGFR). Intensity and extent of Ki-67, MCM-2 and EGFR expressions were evaluated by a scoring formula. The lining epithelium of the maxillary canine follicles had mean scores of 4.65±0.27 for Ki-67, 1.25±0.33 for MCM-2 and 7.30±0.23 for EGFR which were not significantly different than those expressed in the mandibular third molar follicles (4.46±0.26 for Ki-67, 1.39±0.33 for MCM-2 and 7.21±0.20 for EGFR). The expression of Ki-67 and MCM-2 could not be detected in the epithelial remnants within the connective tissue in both groups. EGFR expression, detected in the epithelial remnants in both groups, was not significantly different (7.28±0.14 in the canine group as opposed to 7.21±0.16 in the third molar group). Based on these findings, it can be deduced that impacted mandibular third molars and maxillary canines carry similar risk of pathology development.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.32 n.4 20142014-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000400028en10.4067/S0717-95022014000400028
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Dental follicle Ki-67 MCM-2 EGFR Immunohistochemistry
spellingShingle	Dental follicle Ki-67 MCM-2 EGFR Immunohistochemistry Kömerik,Nurgül Tufan,Alper Kapucuoglu,Nilgün Comparison of Proliferative Activity of Epithelial Cells between the Follicles of Impacted Teeth
description	The aim of this comparative observational study was to compare the proliferative activity of dental follicles surrounding impacted maxillary canines and mandibular third molars. Following extraction, forty follicles of the impacted mandibular third molars and 40 follicles of the impacted maxillary canines were removed. Epithelial cell proliferative activity of these samples was assessed using immunohistochemical labeling for Ki-67, minichromosome maintenance 2 (MCM-2) protein and epithelial growth factor receptor (EGFR). Intensity and extent of Ki-67, MCM-2 and EGFR expressions were evaluated by a scoring formula. The lining epithelium of the maxillary canine follicles had mean scores of 4.65±0.27 for Ki-67, 1.25±0.33 for MCM-2 and 7.30±0.23 for EGFR which were not significantly different than those expressed in the mandibular third molar follicles (4.46±0.26 for Ki-67, 1.39±0.33 for MCM-2 and 7.21±0.20 for EGFR). The expression of Ki-67 and MCM-2 could not be detected in the epithelial remnants within the connective tissue in both groups. EGFR expression, detected in the epithelial remnants in both groups, was not significantly different (7.28±0.14 in the canine group as opposed to 7.21±0.16 in the third molar group). Based on these findings, it can be deduced that impacted mandibular third molars and maxillary canines carry similar risk of pathology development.
author	Kömerik,Nurgül Tufan,Alper Kapucuoglu,Nilgün
author_facet	Kömerik,Nurgül Tufan,Alper Kapucuoglu,Nilgün
author_sort	Kömerik,Nurgül
title	Comparison of Proliferative Activity of Epithelial Cells between the Follicles of Impacted Teeth
title_short	Comparison of Proliferative Activity of Epithelial Cells between the Follicles of Impacted Teeth
title_full	Comparison of Proliferative Activity of Epithelial Cells between the Follicles of Impacted Teeth
title_fullStr	Comparison of Proliferative Activity of Epithelial Cells between the Follicles of Impacted Teeth
title_full_unstemmed	Comparison of Proliferative Activity of Epithelial Cells between the Follicles of Impacted Teeth
title_sort	comparison of proliferative activity of epithelial cells between the follicles of impacted teeth
publisher	Sociedad Chilena de Anatomía
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000400028
work_keys_str_mv	AT komeriknurgul comparisonofproliferativeactivityofepithelialcellsbetweenthefolliclesofimpactedteeth AT tufanalper comparisonofproliferativeactivityofepithelialcellsbetweenthefolliclesofimpactedteeth AT kapucuoglunilgun comparisonofproliferativeactivityofepithelialcellsbetweenthefolliclesofimpactedteeth
_version_	1718444893106339840

Comparison of Proliferative Activity of Epithelial Cells between the Follicles of Impacted Teeth

Ejemplares similares