Distribution and Expression of Visfatin-Positive Cells in the Spleen of Lipopolysaccharide-Stimulated Piglets

The histological changes in the spleen and the immunohistochemical expression of visfatin in lipopolysaccharide-stimulated piglets are reported to examine the relation between visfatin and inflammation. The results are as follows: (1) After LPS treated, the spleen displayed thicker capsules and trab...

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Autores principales:	Xiao,Ke, Qiu,Chang-Wei, Chen,Min, Yang,Zhi, Wang,Jing, Peng,Ke-Mei, Song,Hui
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2014
Materias:	Visfatin Spleen Lipopolysaccharide Piglets
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000400052
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spelling	oai:scielo:S0717-950220140004000522015-11-16Distribution and Expression of Visfatin-Positive Cells in the Spleen of Lipopolysaccharide-Stimulated PigletsXiao,KeQiu,Chang-WeiChen,MinYang,ZhiWang,JingPeng,Ke-MeiSong,Hui Visfatin Spleen Lipopolysaccharide Piglets The histological changes in the spleen and the immunohistochemical expression of visfatin in lipopolysaccharide-stimulated piglets are reported to examine the relation between visfatin and inflammation. The results are as follows: (1) After LPS treated, the spleen displayed thicker capsules and trabecula, the thinner periarterial lymphatic sheath, and the more expandable splenic sinusoid, with an increase in the number of splenic nodules, lymphocytes, ellipsoids of the marginal zone, red blood cells and macrophagocytes. (2) Visfatin-positive cells were mainly distributed in the red pulp of the spleen, with less in splenic nodules and periarterial lymphatic sheath. In the LPS-treated group, the signal intensity and quantity of the visfatin-positive cells were significantly higher in the red pulp and the ellipsoids of the spleen (P<0.01), whereas lower in the periarterial lymphatic sheath. These results indicate that LPS stimulation induces inflammation, causing the histological changes of the piglet spleen and activating humoral immune response. Moreover, variation of visfatin in the spleen suggests that lymphocytes and macrophages are the potent source of visfatin which participates in the humoral immune response in the inflammation.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.32 n.4 20142014-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000400052en10.4067/S0717-95022014000400052
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Visfatin Spleen Lipopolysaccharide Piglets
spellingShingle	Visfatin Spleen Lipopolysaccharide Piglets Xiao,Ke Qiu,Chang-Wei Chen,Min Yang,Zhi Wang,Jing Peng,Ke-Mei Song,Hui Distribution and Expression of Visfatin-Positive Cells in the Spleen of Lipopolysaccharide-Stimulated Piglets
description	The histological changes in the spleen and the immunohistochemical expression of visfatin in lipopolysaccharide-stimulated piglets are reported to examine the relation between visfatin and inflammation. The results are as follows: (1) After LPS treated, the spleen displayed thicker capsules and trabecula, the thinner periarterial lymphatic sheath, and the more expandable splenic sinusoid, with an increase in the number of splenic nodules, lymphocytes, ellipsoids of the marginal zone, red blood cells and macrophagocytes. (2) Visfatin-positive cells were mainly distributed in the red pulp of the spleen, with less in splenic nodules and periarterial lymphatic sheath. In the LPS-treated group, the signal intensity and quantity of the visfatin-positive cells were significantly higher in the red pulp and the ellipsoids of the spleen (P<0.01), whereas lower in the periarterial lymphatic sheath. These results indicate that LPS stimulation induces inflammation, causing the histological changes of the piglet spleen and activating humoral immune response. Moreover, variation of visfatin in the spleen suggests that lymphocytes and macrophages are the potent source of visfatin which participates in the humoral immune response in the inflammation.
author	Xiao,Ke Qiu,Chang-Wei Chen,Min Yang,Zhi Wang,Jing Peng,Ke-Mei Song,Hui
author_facet	Xiao,Ke Qiu,Chang-Wei Chen,Min Yang,Zhi Wang,Jing Peng,Ke-Mei Song,Hui
author_sort	Xiao,Ke
title	Distribution and Expression of Visfatin-Positive Cells in the Spleen of Lipopolysaccharide-Stimulated Piglets
title_short	Distribution and Expression of Visfatin-Positive Cells in the Spleen of Lipopolysaccharide-Stimulated Piglets
title_full	Distribution and Expression of Visfatin-Positive Cells in the Spleen of Lipopolysaccharide-Stimulated Piglets
title_fullStr	Distribution and Expression of Visfatin-Positive Cells in the Spleen of Lipopolysaccharide-Stimulated Piglets
title_full_unstemmed	Distribution and Expression of Visfatin-Positive Cells in the Spleen of Lipopolysaccharide-Stimulated Piglets
title_sort	distribution and expression of visfatin-positive cells in the spleen of lipopolysaccharide-stimulated piglets
publisher	Sociedad Chilena de Anatomía
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000400052
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Distribution and Expression of Visfatin-Positive Cells in the Spleen of Lipopolysaccharide-Stimulated Piglets

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