Ultrastructural Effects of the Propineb on Brain of Fetuses During Rat Pregnancy

Propineb is a fungicide with a propylene-bis-dithiocarbamate structure. Pregnant Wistar rats were exposed to 400 ppm propineb concentrations in 5 ml distilled water, 5 days per week until the end of pregnancy. The rats were treated with propineb for 16 days and the brains of litter rats were sacrifi...

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Autores principales:	Ekinci,C, Tahaoglu,A. E, Yavuz,D, Deveci,E, Aktas,A, Yilmaz,T, Yumusak,Ö, Yükselmis,O
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2014
Materias:	Propineb Electron microscopy Neonatal rats Brain
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000400054
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spelling	oai:scielo:S0717-950220140004000542015-11-16Ultrastructural Effects of the Propineb on Brain of Fetuses During Rat PregnancyEkinci,CTahaoglu,A. EYavuz,DDeveci,EAktas,AYilmaz,TYumusak,ÖYükselmis,O Propineb Electron microscopy Neonatal rats Brain Propineb is a fungicide with a propylene-bis-dithiocarbamate structure. Pregnant Wistar rats were exposed to 400 ppm propineb concentrations in 5 ml distilled water, 5 days per week until the end of pregnancy. The rats were treated with propineb for 16 days and the brains of litter rats were sacrificed at first day of birth after which their brains were collected. Ultrastructural examination of the brains of the fetuses and propineb-treated pregnant females revealed a variety of histopathological effects. We suggest that mitochondrial damage may be an effective factor for neuron necrosis. These results supported the proposal that the exposure to fungicides such as propineb and to other naturally occurring compounds which inhibit mitochondrial function, may contribute to Parkinson's disease development.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.32 n.4 20142014-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000400054en10.4067/S0717-95022014000400054
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Propineb Electron microscopy Neonatal rats Brain
spellingShingle	Propineb Electron microscopy Neonatal rats Brain Ekinci,C Tahaoglu,A. E Yavuz,D Deveci,E Aktas,A Yilmaz,T Yumusak,Ö Yükselmis,O Ultrastructural Effects of the Propineb on Brain of Fetuses During Rat Pregnancy
description	Propineb is a fungicide with a propylene-bis-dithiocarbamate structure. Pregnant Wistar rats were exposed to 400 ppm propineb concentrations in 5 ml distilled water, 5 days per week until the end of pregnancy. The rats were treated with propineb for 16 days and the brains of litter rats were sacrificed at first day of birth after which their brains were collected. Ultrastructural examination of the brains of the fetuses and propineb-treated pregnant females revealed a variety of histopathological effects. We suggest that mitochondrial damage may be an effective factor for neuron necrosis. These results supported the proposal that the exposure to fungicides such as propineb and to other naturally occurring compounds which inhibit mitochondrial function, may contribute to Parkinson's disease development.
author	Ekinci,C Tahaoglu,A. E Yavuz,D Deveci,E Aktas,A Yilmaz,T Yumusak,Ö Yükselmis,O
author_facet	Ekinci,C Tahaoglu,A. E Yavuz,D Deveci,E Aktas,A Yilmaz,T Yumusak,Ö Yükselmis,O
author_sort	Ekinci,C
title	Ultrastructural Effects of the Propineb on Brain of Fetuses During Rat Pregnancy
title_short	Ultrastructural Effects of the Propineb on Brain of Fetuses During Rat Pregnancy
title_full	Ultrastructural Effects of the Propineb on Brain of Fetuses During Rat Pregnancy
title_fullStr	Ultrastructural Effects of the Propineb on Brain of Fetuses During Rat Pregnancy
title_full_unstemmed	Ultrastructural Effects of the Propineb on Brain of Fetuses During Rat Pregnancy
title_sort	ultrastructural effects of the propineb on brain of fetuses during rat pregnancy
publisher	Sociedad Chilena de Anatomía
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000400054
work_keys_str_mv	AT ekincic ultrastructuraleffectsofthepropinebonbrainoffetusesduringratpregnancy AT tahaogluae ultrastructuraleffectsofthepropinebonbrainoffetusesduringratpregnancy AT yavuzd ultrastructuraleffectsofthepropinebonbrainoffetusesduringratpregnancy AT devecie ultrastructuraleffectsofthepropinebonbrainoffetusesduringratpregnancy AT aktasa ultrastructuraleffectsofthepropinebonbrainoffetusesduringratpregnancy AT yilmazt ultrastructuraleffectsofthepropinebonbrainoffetusesduringratpregnancy AT yumusako ultrastructuraleffectsofthepropinebonbrainoffetusesduringratpregnancy AT yukselmiso ultrastructuraleffectsofthepropinebonbrainoffetusesduringratpregnancy
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Ultrastructural Effects of the Propineb on Brain of Fetuses During Rat Pregnancy

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