Pineal Gland Plays a Role in Gonadal Development after Eyelids Separation in Puppies

Several functional and morphological studies have been conducted on the pineal gland in many mammalian species; however, no published reports are available on the role of pineal gland on the gonadal development before and after eyelids separation in puppies. Therefore, this study aimed to trace the...

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Autores principales:	Abou-Easa,Khalil, El-Magd,Mohammed Abu, Tousson,Ehab, Hassanin,Amin, Shukry,Mustafa, Salama,Mohammed
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2015
Materias:	Pineal Testis Ovary Puppy Eyelids separation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000100001
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spelling	oai:scielo:S0717-950220150001000012015-04-09Pineal Gland Plays a Role in Gonadal Development after Eyelids Separation in PuppiesAbou-Easa,KhalilEl-Magd,Mohammed AbuTousson,EhabHassanin,AminShukry,MustafaSalama,Mohammed Pineal Testis Ovary Puppy Eyelids separation Several functional and morphological studies have been conducted on the pineal gland in many mammalian species; however, no published reports are available on the role of pineal gland on the gonadal development before and after eyelids separation in puppies. Therefore, this study aimed to trace the postnatal histo-morphological changes in the pineal gland and gonads of puppies before (2, 10 and 11 days old) and after (25, 35 and 40 days old) eyelids separation in an attempt to investigate the possible role of pineal gland on the gonadal development. In general, the differentiation of pineal cells, interstitial endocrine cells of testes and stromal ovarian cells coincides with the start of eyelids separation in puppies. Histological examination of stained pineal and gonadal slices of puppies after eyelids separation revealed a remarkable differentiation of pinealocytes and testicular interstitial endocrine cells, as well as presence of some evidence of folliculogenesis in ovary. Surprisingly, melatonin receptor (MT1) protein expression levels were significantly increased in the ovaries and testes of puppies after eyelids separation. Moreover, the mRNA and protein expression of AANAT, a rate-limiting enzyme in melatonin biosynthesis, was notably increased in the pineal gland of opened eyes puppies. Our results suggest an increase of melatonin production from the pineal gland of opened eyes puppies and this could play a vital role in the developmental changes observed in the gonads of these puppies.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.33 n.1 20152015-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000100001en10.4067/S0717-95022015000100001
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Pineal Testis Ovary Puppy Eyelids separation
spellingShingle	Pineal Testis Ovary Puppy Eyelids separation Abou-Easa,Khalil El-Magd,Mohammed Abu Tousson,Ehab Hassanin,Amin Shukry,Mustafa Salama,Mohammed Pineal Gland Plays a Role in Gonadal Development after Eyelids Separation in Puppies
description	Several functional and morphological studies have been conducted on the pineal gland in many mammalian species; however, no published reports are available on the role of pineal gland on the gonadal development before and after eyelids separation in puppies. Therefore, this study aimed to trace the postnatal histo-morphological changes in the pineal gland and gonads of puppies before (2, 10 and 11 days old) and after (25, 35 and 40 days old) eyelids separation in an attempt to investigate the possible role of pineal gland on the gonadal development. In general, the differentiation of pineal cells, interstitial endocrine cells of testes and stromal ovarian cells coincides with the start of eyelids separation in puppies. Histological examination of stained pineal and gonadal slices of puppies after eyelids separation revealed a remarkable differentiation of pinealocytes and testicular interstitial endocrine cells, as well as presence of some evidence of folliculogenesis in ovary. Surprisingly, melatonin receptor (MT1) protein expression levels were significantly increased in the ovaries and testes of puppies after eyelids separation. Moreover, the mRNA and protein expression of AANAT, a rate-limiting enzyme in melatonin biosynthesis, was notably increased in the pineal gland of opened eyes puppies. Our results suggest an increase of melatonin production from the pineal gland of opened eyes puppies and this could play a vital role in the developmental changes observed in the gonads of these puppies.
author	Abou-Easa,Khalil El-Magd,Mohammed Abu Tousson,Ehab Hassanin,Amin Shukry,Mustafa Salama,Mohammed
author_facet	Abou-Easa,Khalil El-Magd,Mohammed Abu Tousson,Ehab Hassanin,Amin Shukry,Mustafa Salama,Mohammed
author_sort	Abou-Easa,Khalil
title	Pineal Gland Plays a Role in Gonadal Development after Eyelids Separation in Puppies
title_short	Pineal Gland Plays a Role in Gonadal Development after Eyelids Separation in Puppies
title_full	Pineal Gland Plays a Role in Gonadal Development after Eyelids Separation in Puppies
title_fullStr	Pineal Gland Plays a Role in Gonadal Development after Eyelids Separation in Puppies
title_full_unstemmed	Pineal Gland Plays a Role in Gonadal Development after Eyelids Separation in Puppies
title_sort	pineal gland plays a role in gonadal development after eyelids separation in puppies
publisher	Sociedad Chilena de Anatomía
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000100001
work_keys_str_mv	AT aboueasakhalil pinealglandplaysaroleingonadaldevelopmentaftereyelidsseparationinpuppies AT elmagdmohammedabu pinealglandplaysaroleingonadaldevelopmentaftereyelidsseparationinpuppies AT toussonehab pinealglandplaysaroleingonadaldevelopmentaftereyelidsseparationinpuppies AT hassaninamin pinealglandplaysaroleingonadaldevelopmentaftereyelidsseparationinpuppies AT shukrymustafa pinealglandplaysaroleingonadaldevelopmentaftereyelidsseparationinpuppies AT salamamohammed pinealglandplaysaroleingonadaldevelopmentaftereyelidsseparationinpuppies
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Pineal Gland Plays a Role in Gonadal Development after Eyelids Separation in Puppies

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