The Effects of Polymeric Zinc Propylen-Bis-Dithiocarbamate (Propineb) on Tooth Development in Rats

Dithiocarbamate propinebs are organometal fungicides that are widely used for the control of diseases in plants. In this study, pregnant female rats received 400 ppm propineb concentrations in 5 ml distilled water for 16 days of gestation, and then infant rats were obtained by cesarean section. In t...

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Autores principales:	Mahmut,Koparal, Faruk,Er, Engin,Deveci, Dilek,Yavuz
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2015
Materias:	Propineb MMP2 Tooth buds VEGF
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000100014
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spelling	oai:scielo:S0717-950220150001000142015-04-09The Effects of Polymeric Zinc Propylen-Bis-Dithiocarbamate (Propineb) on Tooth Development in RatsMahmut,KoparalFaruk,ErEngin,DeveciDilek,Yavuz Propineb MMP2 Tooth buds VEGF Dithiocarbamate propinebs are organometal fungicides that are widely used for the control of diseases in plants. In this study, pregnant female rats received 400 ppm propineb concentrations in 5 ml distilled water for 16 days of gestation, and then infant rats were obtained by cesarean section. In the histological analysis on the frontal sections, the use of propineb was found effective on odontoblast cell hyperplasia, cell infiltration in the dental papilla, and degeneration in the mesenchymal cells of the outer enamel. The expression of MMP-2 (Matrix Metalloproteinase-2) and VEGF (Endothelial cell growth factor) in the connective tissue was evaluated by immunohistochemistry. The drinking water given to the mothers in propineb tooth bud, enamel and dentin, resulted in morphological changes suggestive of a delay in formation, which cross the placental barrier and possibly affect the tooth development.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.33 n.1 20152015-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000100014en10.4067/S0717-95022015000100014
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Propineb MMP2 Tooth buds VEGF
spellingShingle	Propineb MMP2 Tooth buds VEGF Mahmut,Koparal Faruk,Er Engin,Deveci Dilek,Yavuz The Effects of Polymeric Zinc Propylen-Bis-Dithiocarbamate (Propineb) on Tooth Development in Rats
description	Dithiocarbamate propinebs are organometal fungicides that are widely used for the control of diseases in plants. In this study, pregnant female rats received 400 ppm propineb concentrations in 5 ml distilled water for 16 days of gestation, and then infant rats were obtained by cesarean section. In the histological analysis on the frontal sections, the use of propineb was found effective on odontoblast cell hyperplasia, cell infiltration in the dental papilla, and degeneration in the mesenchymal cells of the outer enamel. The expression of MMP-2 (Matrix Metalloproteinase-2) and VEGF (Endothelial cell growth factor) in the connective tissue was evaluated by immunohistochemistry. The drinking water given to the mothers in propineb tooth bud, enamel and dentin, resulted in morphological changes suggestive of a delay in formation, which cross the placental barrier and possibly affect the tooth development.
author	Mahmut,Koparal Faruk,Er Engin,Deveci Dilek,Yavuz
author_facet	Mahmut,Koparal Faruk,Er Engin,Deveci Dilek,Yavuz
author_sort	Mahmut,Koparal
title	The Effects of Polymeric Zinc Propylen-Bis-Dithiocarbamate (Propineb) on Tooth Development in Rats
title_short	The Effects of Polymeric Zinc Propylen-Bis-Dithiocarbamate (Propineb) on Tooth Development in Rats
title_full	The Effects of Polymeric Zinc Propylen-Bis-Dithiocarbamate (Propineb) on Tooth Development in Rats
title_fullStr	The Effects of Polymeric Zinc Propylen-Bis-Dithiocarbamate (Propineb) on Tooth Development in Rats
title_full_unstemmed	The Effects of Polymeric Zinc Propylen-Bis-Dithiocarbamate (Propineb) on Tooth Development in Rats
title_sort	effects of polymeric zinc propylen-bis-dithiocarbamate (propineb) on tooth development in rats
publisher	Sociedad Chilena de Anatomía
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000100014
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The Effects of Polymeric Zinc Propylen-Bis-Dithiocarbamate (Propineb) on Tooth Development in Rats

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