Localization of Vesicular Inhibitory Amino Acid Transporter (VIAAT) in the Submandibular Salivary Gland Throughout the Postnatal Development of Mice

According to recent studies, it is highly possible that the occurrence of vesicular inhibitory amino acid transporter (VIAAT) is a good marker of GABA-signaling not only in the brain, but also in extra-brain tissue cells containing GABA and GAD. In view of this, the present study was attempted to lo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Toomsan,Yanyong, Chomphoo,Surang, Pakkarato,Sawetree, Watanabe,Masahiko, Kondo,Hisatake, Hipkaeo,Wiphawi
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2015
Materias:	VIATT-immunoreactivity GABA Salivary glands Arteriolar smooth muscle
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000100019
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-95022015000100019
record_format	dspace
spelling	oai:scielo:S0717-950220150001000192015-04-09Localization of Vesicular Inhibitory Amino Acid Transporter (VIAAT) in the Submandibular Salivary Gland Throughout the Postnatal Development of MiceToomsan,YanyongChomphoo,SurangPakkarato,SawetreeWatanabe,MasahikoKondo,HisatakeHipkaeo,Wiphawi VIATT-immunoreactivity GABA Salivary glands Arteriolar smooth muscle According to recent studies, it is highly possible that the occurrence of vesicular inhibitory amino acid transporter (VIAAT) is a good marker of GABA-signaling not only in the brain, but also in extra-brain tissue cells containing GABA and GAD. In view of this, the present study was attempted to localize VIAAT-immunoreactivity in the submandibular gland of mice. In the present study, the submandibular glands of male mice at various postnatal developmental stages were examined for detailed localization of VIAAT-immunoreactivity in immunohistochemistry at light microscopic level. The immunoreactivity for VIAAT was localized in epithelial cells of proximal and distal excretory ducts with the striated portion more intensely immunopositive at young postnatal stages. No significant immunoreactivity was seen in the acinar cells throughout the postnatal development. In addition, the immunoreactivity for VIAAT was detected in the salivary parasympathetic ganglionic neurons, but not in any nerve fibers surrounding the glandular cells. Furthermore, VIAAT-immunoreactivity was found in smooth muscle cells forming the outermost layer of intralobular arterioles. From the present findings, it is possible that GABA plays roles as paracrine and autocrine regulators in the saliva secretion as well as the gland development.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.33 n.1 20152015-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000100019en10.4067/S0717-95022015000100019
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	VIATT-immunoreactivity GABA Salivary glands Arteriolar smooth muscle
spellingShingle	VIATT-immunoreactivity GABA Salivary glands Arteriolar smooth muscle Toomsan,Yanyong Chomphoo,Surang Pakkarato,Sawetree Watanabe,Masahiko Kondo,Hisatake Hipkaeo,Wiphawi Localization of Vesicular Inhibitory Amino Acid Transporter (VIAAT) in the Submandibular Salivary Gland Throughout the Postnatal Development of Mice
description	According to recent studies, it is highly possible that the occurrence of vesicular inhibitory amino acid transporter (VIAAT) is a good marker of GABA-signaling not only in the brain, but also in extra-brain tissue cells containing GABA and GAD. In view of this, the present study was attempted to localize VIAAT-immunoreactivity in the submandibular gland of mice. In the present study, the submandibular glands of male mice at various postnatal developmental stages were examined for detailed localization of VIAAT-immunoreactivity in immunohistochemistry at light microscopic level. The immunoreactivity for VIAAT was localized in epithelial cells of proximal and distal excretory ducts with the striated portion more intensely immunopositive at young postnatal stages. No significant immunoreactivity was seen in the acinar cells throughout the postnatal development. In addition, the immunoreactivity for VIAAT was detected in the salivary parasympathetic ganglionic neurons, but not in any nerve fibers surrounding the glandular cells. Furthermore, VIAAT-immunoreactivity was found in smooth muscle cells forming the outermost layer of intralobular arterioles. From the present findings, it is possible that GABA plays roles as paracrine and autocrine regulators in the saliva secretion as well as the gland development.
author	Toomsan,Yanyong Chomphoo,Surang Pakkarato,Sawetree Watanabe,Masahiko Kondo,Hisatake Hipkaeo,Wiphawi
author_facet	Toomsan,Yanyong Chomphoo,Surang Pakkarato,Sawetree Watanabe,Masahiko Kondo,Hisatake Hipkaeo,Wiphawi
author_sort	Toomsan,Yanyong
title	Localization of Vesicular Inhibitory Amino Acid Transporter (VIAAT) in the Submandibular Salivary Gland Throughout the Postnatal Development of Mice
title_short	Localization of Vesicular Inhibitory Amino Acid Transporter (VIAAT) in the Submandibular Salivary Gland Throughout the Postnatal Development of Mice
title_full	Localization of Vesicular Inhibitory Amino Acid Transporter (VIAAT) in the Submandibular Salivary Gland Throughout the Postnatal Development of Mice
title_fullStr	Localization of Vesicular Inhibitory Amino Acid Transporter (VIAAT) in the Submandibular Salivary Gland Throughout the Postnatal Development of Mice
title_full_unstemmed	Localization of Vesicular Inhibitory Amino Acid Transporter (VIAAT) in the Submandibular Salivary Gland Throughout the Postnatal Development of Mice
title_sort	localization of vesicular inhibitory amino acid transporter (viaat) in the submandibular salivary gland throughout the postnatal development of mice
publisher	Sociedad Chilena de Anatomía
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000100019
work_keys_str_mv	AT toomsanyanyong localizationofvesicularinhibitoryaminoacidtransporterviaatinthesubmandibularsalivaryglandthroughoutthepostnataldevelopmentofmice AT chomphoosurang localizationofvesicularinhibitoryaminoacidtransporterviaatinthesubmandibularsalivaryglandthroughoutthepostnataldevelopmentofmice AT pakkaratosawetree localizationofvesicularinhibitoryaminoacidtransporterviaatinthesubmandibularsalivaryglandthroughoutthepostnataldevelopmentofmice AT watanabemasahiko localizationofvesicularinhibitoryaminoacidtransporterviaatinthesubmandibularsalivaryglandthroughoutthepostnataldevelopmentofmice AT kondohisatake localizationofvesicularinhibitoryaminoacidtransporterviaatinthesubmandibularsalivaryglandthroughoutthepostnataldevelopmentofmice AT hipkaeowiphawi localizationofvesicularinhibitoryaminoacidtransporterviaatinthesubmandibularsalivaryglandthroughoutthepostnataldevelopmentofmice
_version_	1718444902295011328

Localization of Vesicular Inhibitory Amino Acid Transporter (VIAAT) in the Submandibular Salivary Gland Throughout the Postnatal Development of Mice

Ejemplares similares