Amebic Liver Abscess in Rat: Morphological Evidence of Innate Immune Modulation by the Sympathetic Nervous System

All organs of the immune system are innervated and almost all neurotransmitter receptors are present on immune cells. We studied the effects of sympathetic innervation in the development of amebic liver abscess (ALA) in rats. Our results showed that lack of sympathetic innervation promote a decrease...

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Autores principales:	Muñoz-Ortega,Martín Humberto, Cervantes-García,Daniel, Quintanar-Stephano,Andrés, Campos-Esparza,María del Rosario, García-Lorenzana,Mario, Campos-Rodríguez,R, Rodríguez,M. G, Ventura-Juárez,Javier
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2015
Materias:	Sympathectomy Rat E. histolytica Amebic liver abscess
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000100034
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spelling	oai:scielo:S0717-950220150001000342015-04-09Amebic Liver Abscess in Rat: Morphological Evidence of Innate Immune Modulation by the Sympathetic Nervous SystemMuñoz-Ortega,Martín HumbertoCervantes-García,DanielQuintanar-Stephano,AndrésCampos-Esparza,María del RosarioGarcía-Lorenzana,MarioCampos-Rodríguez,RRodríguez,M. GVentura-Juárez,Javier Sympathectomy Rat E. histolytica Amebic liver abscess All organs of the immune system are innervated and almost all neurotransmitter receptors are present on immune cells. We studied the effects of sympathetic innervation in the development of amebic liver abscess (ALA) in rats. Our results showed that lack of sympathetic innervation promote a decrease in size of ALA. We found scarce amoebas, increased the number of neutrophils and a few collagen fibers surrounding the abscess, meanwhile in control group, we observed abscesses areas with typical necrosis including trophozoites and neutrophils. Macrophages were differentially distributed surrounding abscess area in control and vehicle groups, but equally located in and outside of the abscesses in sympathectomized rat. No significant differences were observed on NK cells in analysed groups. In cytokines quantification studies, we observed down-expression of IFN-g and TNF-a, moreover, we found overexpression of IL-10 in sympathectomized and ALA group. In conclusion, our results suggest that elimination of sympathetic nerve fibers in a model rat of amebic liver abscess induces reduction of the innate immune response and presence of amebas through the liver at seven days post-inoculation.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.33 n.1 20152015-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000100034en10.4067/S0717-95022015000100034
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Sympathectomy Rat E. histolytica Amebic liver abscess
spellingShingle	Sympathectomy Rat E. histolytica Amebic liver abscess Muñoz-Ortega,Martín Humberto Cervantes-García,Daniel Quintanar-Stephano,Andrés Campos-Esparza,María del Rosario García-Lorenzana,Mario Campos-Rodríguez,R Rodríguez,M. G Ventura-Juárez,Javier Amebic Liver Abscess in Rat: Morphological Evidence of Innate Immune Modulation by the Sympathetic Nervous System
description	All organs of the immune system are innervated and almost all neurotransmitter receptors are present on immune cells. We studied the effects of sympathetic innervation in the development of amebic liver abscess (ALA) in rats. Our results showed that lack of sympathetic innervation promote a decrease in size of ALA. We found scarce amoebas, increased the number of neutrophils and a few collagen fibers surrounding the abscess, meanwhile in control group, we observed abscesses areas with typical necrosis including trophozoites and neutrophils. Macrophages were differentially distributed surrounding abscess area in control and vehicle groups, but equally located in and outside of the abscesses in sympathectomized rat. No significant differences were observed on NK cells in analysed groups. In cytokines quantification studies, we observed down-expression of IFN-g and TNF-a, moreover, we found overexpression of IL-10 in sympathectomized and ALA group. In conclusion, our results suggest that elimination of sympathetic nerve fibers in a model rat of amebic liver abscess induces reduction of the innate immune response and presence of amebas through the liver at seven days post-inoculation.
author	Muñoz-Ortega,Martín Humberto Cervantes-García,Daniel Quintanar-Stephano,Andrés Campos-Esparza,María del Rosario García-Lorenzana,Mario Campos-Rodríguez,R Rodríguez,M. G Ventura-Juárez,Javier
author_facet	Muñoz-Ortega,Martín Humberto Cervantes-García,Daniel Quintanar-Stephano,Andrés Campos-Esparza,María del Rosario García-Lorenzana,Mario Campos-Rodríguez,R Rodríguez,M. G Ventura-Juárez,Javier
author_sort	Muñoz-Ortega,Martín Humberto
title	Amebic Liver Abscess in Rat: Morphological Evidence of Innate Immune Modulation by the Sympathetic Nervous System
title_short	Amebic Liver Abscess in Rat: Morphological Evidence of Innate Immune Modulation by the Sympathetic Nervous System
title_full	Amebic Liver Abscess in Rat: Morphological Evidence of Innate Immune Modulation by the Sympathetic Nervous System
title_fullStr	Amebic Liver Abscess in Rat: Morphological Evidence of Innate Immune Modulation by the Sympathetic Nervous System
title_full_unstemmed	Amebic Liver Abscess in Rat: Morphological Evidence of Innate Immune Modulation by the Sympathetic Nervous System
title_sort	amebic liver abscess in rat: morphological evidence of innate immune modulation by the sympathetic nervous system
publisher	Sociedad Chilena de Anatomía
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000100034
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Amebic Liver Abscess in Rat: Morphological Evidence of Innate Immune Modulation by the Sympathetic Nervous System

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