Histological Evaluation of the Effects of Borax Obtained from Various Sources in Different Rat Organs

Boron is an essential element for life and intake via different sources into the body. Because effects of boron and compounds on the body has not been studied enough especially in tissue level, we planned this study to evaluate the effects of borax the most intaken form of boron compound on differen...

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Autores principales:	Kabu,Mustafa, Tosun,Murat, Elitok,Bülent, Akosman,Murat Sirri
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2015
Materias:	Boron Borax Inflammatory bowel disease Histopathology Toxicology
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000100040
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spelling	oai:scielo:S0717-950220150001000402015-04-09Histological Evaluation of the Effects of Borax Obtained from Various Sources in Different Rat OrgansKabu,MustafaTosun,MuratElitok,BülentAkosman,Murat Sirri Boron Borax Inflammatory bowel disease Histopathology Toxicology Boron is an essential element for life and intake via different sources into the body. Because effects of boron and compounds on the body has not been studied enough especially in tissue level, we planned this study to evaluate the effects of borax the most intaken form of boron compound on different intraabdominal organs histologically and also clinically. 42 male rats divided into equal 7 groups and different toxicological doses consistent with its LD50 dose (5000 mg/kg/d) were administered by gavage except control and sham groups. In the study, 2 different kinds of borax one of which was produced for research and the other for agriculture but the same formulation, were used and their effects were also compared. As a result it was found that borax did not cause any histological changes in kidney, large intestine, liver and stomach in lower doses. But if doses were increased, a slightly inflammatory cell migration was detected without clinical signs in liver and large intestine. However, when a single very high dose of borax was administered, very high edema, inflammatory cell migration and neovascularization was observed and clinically 2 out of 6 rats died within 5 hours. We suggested that very high dose intake of borax may cause sudden death and also during long periods and higher dose intake may pave the way of inflammatory bowel diseases. At the same time, in boron related studies we advice that the kind of boron and also their source should be evaluated carefully and the most suitable compound should be chosen in case of faulty results.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.33 n.1 20152015-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000100040en10.4067/S0717-95022015000100040
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Boron Borax Inflammatory bowel disease Histopathology Toxicology
spellingShingle	Boron Borax Inflammatory bowel disease Histopathology Toxicology Kabu,Mustafa Tosun,Murat Elitok,Bülent Akosman,Murat Sirri Histological Evaluation of the Effects of Borax Obtained from Various Sources in Different Rat Organs
description	Boron is an essential element for life and intake via different sources into the body. Because effects of boron and compounds on the body has not been studied enough especially in tissue level, we planned this study to evaluate the effects of borax the most intaken form of boron compound on different intraabdominal organs histologically and also clinically. 42 male rats divided into equal 7 groups and different toxicological doses consistent with its LD50 dose (5000 mg/kg/d) were administered by gavage except control and sham groups. In the study, 2 different kinds of borax one of which was produced for research and the other for agriculture but the same formulation, were used and their effects were also compared. As a result it was found that borax did not cause any histological changes in kidney, large intestine, liver and stomach in lower doses. But if doses were increased, a slightly inflammatory cell migration was detected without clinical signs in liver and large intestine. However, when a single very high dose of borax was administered, very high edema, inflammatory cell migration and neovascularization was observed and clinically 2 out of 6 rats died within 5 hours. We suggested that very high dose intake of borax may cause sudden death and also during long periods and higher dose intake may pave the way of inflammatory bowel diseases. At the same time, in boron related studies we advice that the kind of boron and also their source should be evaluated carefully and the most suitable compound should be chosen in case of faulty results.
author	Kabu,Mustafa Tosun,Murat Elitok,Bülent Akosman,Murat Sirri
author_facet	Kabu,Mustafa Tosun,Murat Elitok,Bülent Akosman,Murat Sirri
author_sort	Kabu,Mustafa
title	Histological Evaluation of the Effects of Borax Obtained from Various Sources in Different Rat Organs
title_short	Histological Evaluation of the Effects of Borax Obtained from Various Sources in Different Rat Organs
title_full	Histological Evaluation of the Effects of Borax Obtained from Various Sources in Different Rat Organs
title_fullStr	Histological Evaluation of the Effects of Borax Obtained from Various Sources in Different Rat Organs
title_full_unstemmed	Histological Evaluation of the Effects of Borax Obtained from Various Sources in Different Rat Organs
title_sort	histological evaluation of the effects of borax obtained from various sources in different rat organs
publisher	Sociedad Chilena de Anatomía
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000100040
work_keys_str_mv	AT kabumustafa histologicalevaluationoftheeffectsofboraxobtainedfromvarioussourcesindifferentratorgans AT tosunmurat histologicalevaluationoftheeffectsofboraxobtainedfromvarioussourcesindifferentratorgans AT elitokbulent histologicalevaluationoftheeffectsofboraxobtainedfromvarioussourcesindifferentratorgans AT akosmanmuratsirri histologicalevaluationoftheeffectsofboraxobtainedfromvarioussourcesindifferentratorgans
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Histological Evaluation of the Effects of Borax Obtained from Various Sources in Different Rat Organs

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