Micro Hardness of Dental Tissues Influenced by Administration of Aspirin During Pregnancy

The study is associated with the effect of aspirin (Acetyl Salicylic Acid) on the microhardness of mineralized tissues of the offspring's teeth, in response to the ingestion of the drug during pregnancy. Aspirin is a widely used analgesic and antipyretic medicine, for symptomatic treatment. Mis...

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Autores principales:	Shakila,Nazir, Ali,Ashraf, Zaidi,Shoaib
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2015
Materias:	Dentition Aspirin Female rabbits Teratogenic effect Microhardness
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000200028
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spelling	oai:scielo:S0717-950220150002000282015-08-13Micro Hardness of Dental Tissues Influenced by Administration of Aspirin During PregnancyShakila,NazirAli,AshrafZaidi,Shoaib Dentition Aspirin Female rabbits Teratogenic effect Microhardness The study is associated with the effect of aspirin (Acetyl Salicylic Acid) on the microhardness of mineralized tissues of the offspring's teeth, in response to the ingestion of the drug during pregnancy. Aspirin is a widely used analgesic and antipyretic medicine, for symptomatic treatment. Misuse of this drug during pregnancy may instigate developmental defects in offspring. An experimental control study was designed, in which female rabbits were taken as representative mammalian models and treated with aspirin during pregnancy. Their offspring's teeth were used to assess the microhardness of dental tissues. The rabbits were alienated into two groups, treated and control, consisting of seven rabbits in each set (n= 7). Microhardness was evaluated in three types of the sample teeth. The total number of teeth examined were, 2x7x12= 168 samples. Vicker's Hardness degree values were measured and recorded vis-à-vis (50 g for 15 s with 3 indentations per specimen on enamel and dentine separately). The range of hardness obtained was statistically analyzed and the Student's t-tests was applied, with the aid of SPSS version 20. The P-values for both enamel and dentine from maxillary incisors and molars were less than 0.05. The same trend was observed in the mandibular teeth. However, a teratogenicity of Acetyl Salicylic Acid was pragmatic in the recent in vivo studies. Based on the analysis, it was evident that the aspirin administration could produce negative effects leading to reduction in the microhardness of dental tissues of the offsprings.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.33 n.2 20152015-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000200028en10.4067/S0717-95022015000200028
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Dentition Aspirin Female rabbits Teratogenic effect Microhardness
spellingShingle	Dentition Aspirin Female rabbits Teratogenic effect Microhardness Shakila,Nazir Ali,Ashraf Zaidi,Shoaib Micro Hardness of Dental Tissues Influenced by Administration of Aspirin During Pregnancy
description	The study is associated with the effect of aspirin (Acetyl Salicylic Acid) on the microhardness of mineralized tissues of the offspring's teeth, in response to the ingestion of the drug during pregnancy. Aspirin is a widely used analgesic and antipyretic medicine, for symptomatic treatment. Misuse of this drug during pregnancy may instigate developmental defects in offspring. An experimental control study was designed, in which female rabbits were taken as representative mammalian models and treated with aspirin during pregnancy. Their offspring's teeth were used to assess the microhardness of dental tissues. The rabbits were alienated into two groups, treated and control, consisting of seven rabbits in each set (n= 7). Microhardness was evaluated in three types of the sample teeth. The total number of teeth examined were, 2x7x12= 168 samples. Vicker's Hardness degree values were measured and recorded vis-à-vis (50 g for 15 s with 3 indentations per specimen on enamel and dentine separately). The range of hardness obtained was statistically analyzed and the Student's t-tests was applied, with the aid of SPSS version 20. The P-values for both enamel and dentine from maxillary incisors and molars were less than 0.05. The same trend was observed in the mandibular teeth. However, a teratogenicity of Acetyl Salicylic Acid was pragmatic in the recent in vivo studies. Based on the analysis, it was evident that the aspirin administration could produce negative effects leading to reduction in the microhardness of dental tissues of the offsprings.
author	Shakila,Nazir Ali,Ashraf Zaidi,Shoaib
author_facet	Shakila,Nazir Ali,Ashraf Zaidi,Shoaib
author_sort	Shakila,Nazir
title	Micro Hardness of Dental Tissues Influenced by Administration of Aspirin During Pregnancy
title_short	Micro Hardness of Dental Tissues Influenced by Administration of Aspirin During Pregnancy
title_full	Micro Hardness of Dental Tissues Influenced by Administration of Aspirin During Pregnancy
title_fullStr	Micro Hardness of Dental Tissues Influenced by Administration of Aspirin During Pregnancy
title_full_unstemmed	Micro Hardness of Dental Tissues Influenced by Administration of Aspirin During Pregnancy
title_sort	micro hardness of dental tissues influenced by administration of aspirin during pregnancy
publisher	Sociedad Chilena de Anatomía
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000200028
work_keys_str_mv	AT shakilanazir microhardnessofdentaltissuesinfluencedbyadministrationofaspirinduringpregnancy AT aliashraf microhardnessofdentaltissuesinfluencedbyadministrationofaspirinduringpregnancy AT zaidishoaib microhardnessofdentaltissuesinfluencedbyadministrationofaspirinduringpregnancy
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Micro Hardness of Dental Tissues Influenced by Administration of Aspirin During Pregnancy

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