Osseointegration of Hydroxyapatite Implants in Rat Tibial Defects with Sciatic Nerve Injury

Bone metabolism is influenced by different factors and muscle activity acts as a stimulator of bone plasticity. Conditions such as nerve injuries can compromise bone physiology due to muscle inactivity. Preview studies have shown that nerve damage reduces P substance and calcitonin gene-related pept...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	da Cunha,Marcelo Rodrigues, Laraia,Isabela Ortiz, Franco,Guacira R, Miguel,Natalia N, Maciel,Ana A, dos Santos,Geovane Ribeiro, Isayama,Ricardo Noboro
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2015
Materias:	Hydroxyapatite Sciatic nerve Bone healing
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000200033
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-95022015000200033
record_format	dspace
spelling	oai:scielo:S0717-950220150002000332015-08-13Osseointegration of Hydroxyapatite Implants in Rat Tibial Defects with Sciatic Nerve Injuryda Cunha,Marcelo RodriguesLaraia,Isabela OrtizFranco,Guacira RMiguel,Natalia NMaciel,Ana Ados Santos,Geovane RibeiroIsayama,Ricardo Noboro Hydroxyapatite Sciatic nerve Bone healing Bone metabolism is influenced by different factors and muscle activity acts as a stimulator of bone plasticity. Conditions such as nerve injuries can compromise bone physiology due to muscle inactivity. Preview studies have shown that nerve damage reduces P substance and calcitonin gene-related peptides, also known as neuropeptides that may have a key role on bone healing. Therefore, this study evaluated the osseointegration of hydroxyapatite implants in tibial defects of rats submitted to unilateral sciatic nerve section. Twelve Wistar rats were divided into two groups (G1 and G2). In G1, the sciatic nerve was left intact and in G2 the left sciatic nerve was completely sectioned. An experimental tibial bone defect was then created in both groups and filled with hydroxyapatite granules. The animals were sacrificed 2 months after implantation and samples were submitted to macroscopic inspection and histological analysis. Good radiopacity of the hydroxyapatite granules and radiographic definition of the bone defect were noted. Histologic analysis revealed formation of new bone adjacent to the hydroxyapatite granules in G1 and, to a lesser extent, in G2 in which the proliferation of connective tissue predominated at the implant site. The formation of new bone stimulated by hydroxyapatite in bone defects can be expected even in animals with limb paralysis due to nerve injury; however, bone formation occurs at a slower speed in these animals and the volume of newly formed bone is lower.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.33 n.2 20152015-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000200033en10.4067/S0717-95022015000200033
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Hydroxyapatite Sciatic nerve Bone healing
spellingShingle	Hydroxyapatite Sciatic nerve Bone healing da Cunha,Marcelo Rodrigues Laraia,Isabela Ortiz Franco,Guacira R Miguel,Natalia N Maciel,Ana A dos Santos,Geovane Ribeiro Isayama,Ricardo Noboro Osseointegration of Hydroxyapatite Implants in Rat Tibial Defects with Sciatic Nerve Injury
description	Bone metabolism is influenced by different factors and muscle activity acts as a stimulator of bone plasticity. Conditions such as nerve injuries can compromise bone physiology due to muscle inactivity. Preview studies have shown that nerve damage reduces P substance and calcitonin gene-related peptides, also known as neuropeptides that may have a key role on bone healing. Therefore, this study evaluated the osseointegration of hydroxyapatite implants in tibial defects of rats submitted to unilateral sciatic nerve section. Twelve Wistar rats were divided into two groups (G1 and G2). In G1, the sciatic nerve was left intact and in G2 the left sciatic nerve was completely sectioned. An experimental tibial bone defect was then created in both groups and filled with hydroxyapatite granules. The animals were sacrificed 2 months after implantation and samples were submitted to macroscopic inspection and histological analysis. Good radiopacity of the hydroxyapatite granules and radiographic definition of the bone defect were noted. Histologic analysis revealed formation of new bone adjacent to the hydroxyapatite granules in G1 and, to a lesser extent, in G2 in which the proliferation of connective tissue predominated at the implant site. The formation of new bone stimulated by hydroxyapatite in bone defects can be expected even in animals with limb paralysis due to nerve injury; however, bone formation occurs at a slower speed in these animals and the volume of newly formed bone is lower.
author	da Cunha,Marcelo Rodrigues Laraia,Isabela Ortiz Franco,Guacira R Miguel,Natalia N Maciel,Ana A dos Santos,Geovane Ribeiro Isayama,Ricardo Noboro
author_facet	da Cunha,Marcelo Rodrigues Laraia,Isabela Ortiz Franco,Guacira R Miguel,Natalia N Maciel,Ana A dos Santos,Geovane Ribeiro Isayama,Ricardo Noboro
author_sort	da Cunha,Marcelo Rodrigues
title	Osseointegration of Hydroxyapatite Implants in Rat Tibial Defects with Sciatic Nerve Injury
title_short	Osseointegration of Hydroxyapatite Implants in Rat Tibial Defects with Sciatic Nerve Injury
title_full	Osseointegration of Hydroxyapatite Implants in Rat Tibial Defects with Sciatic Nerve Injury
title_fullStr	Osseointegration of Hydroxyapatite Implants in Rat Tibial Defects with Sciatic Nerve Injury
title_full_unstemmed	Osseointegration of Hydroxyapatite Implants in Rat Tibial Defects with Sciatic Nerve Injury
title_sort	osseointegration of hydroxyapatite implants in rat tibial defects with sciatic nerve injury
publisher	Sociedad Chilena de Anatomía
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000200033
work_keys_str_mv	AT dacunhamarcelorodrigues osseointegrationofhydroxyapatiteimplantsinrattibialdefectswithsciaticnerveinjury AT laraiaisabelaortiz osseointegrationofhydroxyapatiteimplantsinrattibialdefectswithsciaticnerveinjury AT francoguacirar osseointegrationofhydroxyapatiteimplantsinrattibialdefectswithsciaticnerveinjury AT miguelnatalian osseointegrationofhydroxyapatiteimplantsinrattibialdefectswithsciaticnerveinjury AT macielanaa osseointegrationofhydroxyapatiteimplantsinrattibialdefectswithsciaticnerveinjury AT dossantosgeovaneribeiro osseointegrationofhydroxyapatiteimplantsinrattibialdefectswithsciaticnerveinjury AT isayamaricardonoboro osseointegrationofhydroxyapatiteimplantsinrattibialdefectswithsciaticnerveinjury
_version_	1718444916552499200

Osseointegration of Hydroxyapatite Implants in Rat Tibial Defects with Sciatic Nerve Injury

Ejemplares similares