Localization of Cannabinoid Receptor 1 (CB1) in Submandibular and Sublingual Salivary Glands of Mice throughout Postnatal Development

In view of the fact that human marijuana users often show dry mouth symptom, the present study was attempted to examine the localization of CB1, which was originally identified in brain, in the submandibular and sublingual salivary glands of postnatal developing male mice by immunohistochemistry. In...

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Autores principales:	Hipkaeo,Wiphawi, Watanabe,Masahiko, Kondo,Hisatake
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2015
Materias:	Cannabinoid receptor 1 Immunohistochemistry Submandibular gland Sublingual gland Postnatal mice
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000200044
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spelling	oai:scielo:S0717-950220150002000442015-08-13Localization of Cannabinoid Receptor 1 (CB1) in Submandibular and Sublingual Salivary Glands of Mice throughout Postnatal DevelopmentHipkaeo,WiphawiWatanabe,MasahikoKondo,Hisatake Cannabinoid receptor 1 Immunohistochemistry Submandibular gland Sublingual gland Postnatal mice In view of the fact that human marijuana users often show dry mouth symptom, the present study was attempted to examine the localization of CB1, which was originally identified in brain, in the submandibular and sublingual salivary glands of postnatal developing male mice by immunohistochemistry. In submandibular gland, CB1-immunoreactivity was positive in a majority of acinar cells in forms of granular appearance in their apical cytoplasm, while it was negative in the ducts at newborn stage. The immunoreactivity decreased in the acinar cells at P1W and no immunoreactivity was detected in the acinar cells at P3W and thereafter. The immunoreactivity was positive in ductal cells at P3W and it remained positive thereafter until P8W stage. The immunoreaction was distinct on the apical plasmalemma of the intercalated ductal cells, while it was distinct on the basal plasmalemma of the granular convoluted ductal cells. The enhanced immunostaining on the lateral plasmalemma of the granular ductal cells was discerned only on P6W. In sublingual gland, CB1-immunoreactivity was detected in the demilune acinar cells and ductal cells only on P4W. Furthermore, CB1-immunoreactivity was shown to occur in the salivary ganglionic neurons, suggesting the CB1-inhibitory action in the saliva secretion through the parasympathetic nervous transmission.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.33 n.2 20152015-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000200044en10.4067/S0717-95022015000200044
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Cannabinoid receptor 1 Immunohistochemistry Submandibular gland Sublingual gland Postnatal mice
spellingShingle	Cannabinoid receptor 1 Immunohistochemistry Submandibular gland Sublingual gland Postnatal mice Hipkaeo,Wiphawi Watanabe,Masahiko Kondo,Hisatake Localization of Cannabinoid Receptor 1 (CB1) in Submandibular and Sublingual Salivary Glands of Mice throughout Postnatal Development
description	In view of the fact that human marijuana users often show dry mouth symptom, the present study was attempted to examine the localization of CB1, which was originally identified in brain, in the submandibular and sublingual salivary glands of postnatal developing male mice by immunohistochemistry. In submandibular gland, CB1-immunoreactivity was positive in a majority of acinar cells in forms of granular appearance in their apical cytoplasm, while it was negative in the ducts at newborn stage. The immunoreactivity decreased in the acinar cells at P1W and no immunoreactivity was detected in the acinar cells at P3W and thereafter. The immunoreactivity was positive in ductal cells at P3W and it remained positive thereafter until P8W stage. The immunoreaction was distinct on the apical plasmalemma of the intercalated ductal cells, while it was distinct on the basal plasmalemma of the granular convoluted ductal cells. The enhanced immunostaining on the lateral plasmalemma of the granular ductal cells was discerned only on P6W. In sublingual gland, CB1-immunoreactivity was detected in the demilune acinar cells and ductal cells only on P4W. Furthermore, CB1-immunoreactivity was shown to occur in the salivary ganglionic neurons, suggesting the CB1-inhibitory action in the saliva secretion through the parasympathetic nervous transmission.
author	Hipkaeo,Wiphawi Watanabe,Masahiko Kondo,Hisatake
author_facet	Hipkaeo,Wiphawi Watanabe,Masahiko Kondo,Hisatake
author_sort	Hipkaeo,Wiphawi
title	Localization of Cannabinoid Receptor 1 (CB1) in Submandibular and Sublingual Salivary Glands of Mice throughout Postnatal Development
title_short	Localization of Cannabinoid Receptor 1 (CB1) in Submandibular and Sublingual Salivary Glands of Mice throughout Postnatal Development
title_full	Localization of Cannabinoid Receptor 1 (CB1) in Submandibular and Sublingual Salivary Glands of Mice throughout Postnatal Development
title_fullStr	Localization of Cannabinoid Receptor 1 (CB1) in Submandibular and Sublingual Salivary Glands of Mice throughout Postnatal Development
title_full_unstemmed	Localization of Cannabinoid Receptor 1 (CB1) in Submandibular and Sublingual Salivary Glands of Mice throughout Postnatal Development
title_sort	localization of cannabinoid receptor 1 (cb1) in submandibular and sublingual salivary glands of mice throughout postnatal development
publisher	Sociedad Chilena de Anatomía
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000200044
work_keys_str_mv	AT hipkaeowiphawi localizationofcannabinoidreceptor1cb1insubmandibularandsublingualsalivaryglandsofmicethroughoutpostnataldevelopment AT watanabemasahiko localizationofcannabinoidreceptor1cb1insubmandibularandsublingualsalivaryglandsofmicethroughoutpostnataldevelopment AT kondohisatake localizationofcannabinoidreceptor1cb1insubmandibularandsublingualsalivaryglandsofmicethroughoutpostnataldevelopment
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Localization of Cannabinoid Receptor 1 (CB1) in Submandibular and Sublingual Salivary Glands of Mice throughout Postnatal Development

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