Hind Limb Sensory Innervation in Rats: Comparison between Sural and Saphenous Nerve Morphometry

Although numerous studies investigate sensory recovery of the hind paw of the rat after nerve damage, still no comprehensive overview of its normal innervation is present in the literature. We investigated the morphometry of myelinated fibers in the sural and saphenous nerves and analyzed their size...

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Autores principales:	Neri,Letícia Oliveira, de Amorim,Milena Menezes, Campos,Stella Andrade Rodrigues, Sanada,Luciana Sayuri, Fazan,Valéria Paula Sassoli
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2015
Materias:	Sural nerve Saphenous nerve Morphometry Myelinated fibers
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000200052
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spelling	oai:scielo:S0717-950220150002000522015-08-13Hind Limb Sensory Innervation in Rats: Comparison between Sural and Saphenous Nerve MorphometryNeri,Letícia Oliveirade Amorim,Milena MenezesCampos,Stella Andrade RodriguesSanada,Luciana SayuriFazan,Valéria Paula Sassoli Sural nerve Saphenous nerve Morphometry Myelinated fibers Although numerous studies investigate sensory recovery of the hind paw of the rat after nerve damage, still no comprehensive overview of its normal innervation is present in the literature. We investigated the morphometry of myelinated fibers in the sural and saphenous nerves and analyzed their size distributions in young rats. Six 30-day-old female Wistar rats were perfused with 2.5% glutaraldehyde and their right and left sural and saphenous nerves were prepared for light microscopy and morphometry. Morphometric data were compared between segments (proximal versus distal) and sides (right versus left) for the same nerves. Also, segments from right or left sides were compared between nerves (sural versus saphenous). Both, the sural and saphenous nerves, exhibited proximal to distal symmetry on both sides as well as left-right symmetry. Histograms of the diameter of the myelinated fibers were unimodal in both nerves, regardless of segments or sides with the peaks of the fibers size occurring between 2.5 and 4.0 µm. The axon distributions reflected the myelinated fiber distributions, with the sural and saphenous nerves peaking between 1.5 and 2.0 µm. The G ratio (the ratio between the axon and fiber diameters) distributions were also unimodal, with peaks at 0.6 for both nerves. This study contributes to the literature with information on the myelinated fibers morphometry from the two sensory nerves responsible for the rat hind limb innervation. This information is valuable for a better understanding of the possible contribution of collateral sprouting from the sural or saphenous nerves on the paw sensory territory recovery observed after one of these nerves is damaged.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.33 n.2 20152015-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000200052en10.4067/S0717-95022015000200052
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Sural nerve Saphenous nerve Morphometry Myelinated fibers
spellingShingle	Sural nerve Saphenous nerve Morphometry Myelinated fibers Neri,Letícia Oliveira de Amorim,Milena Menezes Campos,Stella Andrade Rodrigues Sanada,Luciana Sayuri Fazan,Valéria Paula Sassoli Hind Limb Sensory Innervation in Rats: Comparison between Sural and Saphenous Nerve Morphometry
description	Although numerous studies investigate sensory recovery of the hind paw of the rat after nerve damage, still no comprehensive overview of its normal innervation is present in the literature. We investigated the morphometry of myelinated fibers in the sural and saphenous nerves and analyzed their size distributions in young rats. Six 30-day-old female Wistar rats were perfused with 2.5% glutaraldehyde and their right and left sural and saphenous nerves were prepared for light microscopy and morphometry. Morphometric data were compared between segments (proximal versus distal) and sides (right versus left) for the same nerves. Also, segments from right or left sides were compared between nerves (sural versus saphenous). Both, the sural and saphenous nerves, exhibited proximal to distal symmetry on both sides as well as left-right symmetry. Histograms of the diameter of the myelinated fibers were unimodal in both nerves, regardless of segments or sides with the peaks of the fibers size occurring between 2.5 and 4.0 µm. The axon distributions reflected the myelinated fiber distributions, with the sural and saphenous nerves peaking between 1.5 and 2.0 µm. The G ratio (the ratio between the axon and fiber diameters) distributions were also unimodal, with peaks at 0.6 for both nerves. This study contributes to the literature with information on the myelinated fibers morphometry from the two sensory nerves responsible for the rat hind limb innervation. This information is valuable for a better understanding of the possible contribution of collateral sprouting from the sural or saphenous nerves on the paw sensory territory recovery observed after one of these nerves is damaged.
author	Neri,Letícia Oliveira de Amorim,Milena Menezes Campos,Stella Andrade Rodrigues Sanada,Luciana Sayuri Fazan,Valéria Paula Sassoli
author_facet	Neri,Letícia Oliveira de Amorim,Milena Menezes Campos,Stella Andrade Rodrigues Sanada,Luciana Sayuri Fazan,Valéria Paula Sassoli
author_sort	Neri,Letícia Oliveira
title	Hind Limb Sensory Innervation in Rats: Comparison between Sural and Saphenous Nerve Morphometry
title_short	Hind Limb Sensory Innervation in Rats: Comparison between Sural and Saphenous Nerve Morphometry
title_full	Hind Limb Sensory Innervation in Rats: Comparison between Sural and Saphenous Nerve Morphometry
title_fullStr	Hind Limb Sensory Innervation in Rats: Comparison between Sural and Saphenous Nerve Morphometry
title_full_unstemmed	Hind Limb Sensory Innervation in Rats: Comparison between Sural and Saphenous Nerve Morphometry
title_sort	hind limb sensory innervation in rats: comparison between sural and saphenous nerve morphometry
publisher	Sociedad Chilena de Anatomía
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000200052
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Hind Limb Sensory Innervation in Rats: Comparison between Sural and Saphenous Nerve Morphometry

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