Regenerative Capacity and Histomorphometric Changes in Rat Sciatic Nerve Following Experimental Neurotmesis

Through a wide range of cellular and molecular events, the peripheral nervous system is endowed with great regenerative capacity, responding immediately to injuries that occur along the length of the nerve. The aim of this study was to histomorphometrically assess the degree of maturity of the nervo...

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Autores principales:	Lós,Deniele Bezerra, Novaes,Karyne Albino, de Miranda,Filipe Barbosa Cunha, Lira,Kamilla Dinah Santos de, Andrade,Rodrigo Fragoso de, Moraes,Sílvia Regina Arruda de
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2015
Materias:	Nerve Tissue Nerve Regeneration Peripheral Nerve Injuries Vasa nervorum Histology
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000200056
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spelling	oai:scielo:S0717-950220150002000562015-08-13Regenerative Capacity and Histomorphometric Changes in Rat Sciatic Nerve Following Experimental NeurotmesisLós,Deniele BezerraNovaes,Karyne Albinode Miranda,Filipe Barbosa CunhaLira,Kamilla Dinah Santos deAndrade,Rodrigo Fragoso deMoraes,Sílvia Regina Arruda de Nerve Tissue Nerve Regeneration Peripheral Nerve Injuries Vasa nervorum Histology Through a wide range of cellular and molecular events, the peripheral nervous system is endowed with great regenerative capacity, responding immediately to injuries that occur along the length of the nerve. The aim of this study was to histomorphometrically assess the degree of maturity of the nervous tissue and possible microscopic changes in newly formed nerve segments 60 days after experimental neurotmesis of the sciatic nerve in rats. Control Group (CG) and an Injury Group (IG) were used. IG underwent neurotmesis of the sciatic nerve of the right foot, with immediate surgical repair using the tubulization technique. 60 days following experimental surgery, animals from both groups had their sciatic nerves collected for histomorphometric analysis. Statistical analysis was performed, using the Student t-test for independent samples, expressed as mean ± standard deviation, with 5% significance. In the event of injury, peripheral nerve tissue is mobilized in an intrinsic self-healing process. 60 days following of nerve regeneration in neurotmesis injury, the peripheral nerve presents a segment joining the newly formed neural stump. The new stump has a number of regenerated axons compatible with an intact nerve, but which still show great immaturity in the axonal structural layers of the nerve.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.33 n.2 20152015-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000200056en10.4067/S0717-95022015000200056
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Nerve Tissue Nerve Regeneration Peripheral Nerve Injuries Vasa nervorum Histology
spellingShingle	Nerve Tissue Nerve Regeneration Peripheral Nerve Injuries Vasa nervorum Histology Lós,Deniele Bezerra Novaes,Karyne Albino de Miranda,Filipe Barbosa Cunha Lira,Kamilla Dinah Santos de Andrade,Rodrigo Fragoso de Moraes,Sílvia Regina Arruda de Regenerative Capacity and Histomorphometric Changes in Rat Sciatic Nerve Following Experimental Neurotmesis
description	Through a wide range of cellular and molecular events, the peripheral nervous system is endowed with great regenerative capacity, responding immediately to injuries that occur along the length of the nerve. The aim of this study was to histomorphometrically assess the degree of maturity of the nervous tissue and possible microscopic changes in newly formed nerve segments 60 days after experimental neurotmesis of the sciatic nerve in rats. Control Group (CG) and an Injury Group (IG) were used. IG underwent neurotmesis of the sciatic nerve of the right foot, with immediate surgical repair using the tubulization technique. 60 days following experimental surgery, animals from both groups had their sciatic nerves collected for histomorphometric analysis. Statistical analysis was performed, using the Student t-test for independent samples, expressed as mean ± standard deviation, with 5% significance. In the event of injury, peripheral nerve tissue is mobilized in an intrinsic self-healing process. 60 days following of nerve regeneration in neurotmesis injury, the peripheral nerve presents a segment joining the newly formed neural stump. The new stump has a number of regenerated axons compatible with an intact nerve, but which still show great immaturity in the axonal structural layers of the nerve.
author	Lós,Deniele Bezerra Novaes,Karyne Albino de Miranda,Filipe Barbosa Cunha Lira,Kamilla Dinah Santos de Andrade,Rodrigo Fragoso de Moraes,Sílvia Regina Arruda de
author_facet	Lós,Deniele Bezerra Novaes,Karyne Albino de Miranda,Filipe Barbosa Cunha Lira,Kamilla Dinah Santos de Andrade,Rodrigo Fragoso de Moraes,Sílvia Regina Arruda de
author_sort	Lós,Deniele Bezerra
title	Regenerative Capacity and Histomorphometric Changes in Rat Sciatic Nerve Following Experimental Neurotmesis
title_short	Regenerative Capacity and Histomorphometric Changes in Rat Sciatic Nerve Following Experimental Neurotmesis
title_full	Regenerative Capacity and Histomorphometric Changes in Rat Sciatic Nerve Following Experimental Neurotmesis
title_fullStr	Regenerative Capacity and Histomorphometric Changes in Rat Sciatic Nerve Following Experimental Neurotmesis
title_full_unstemmed	Regenerative Capacity and Histomorphometric Changes in Rat Sciatic Nerve Following Experimental Neurotmesis
title_sort	regenerative capacity and histomorphometric changes in rat sciatic nerve following experimental neurotmesis
publisher	Sociedad Chilena de Anatomía
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000200056
work_keys_str_mv	AT losdenielebezerra regenerativecapacityandhistomorphometricchangesinratsciaticnervefollowingexperimentalneurotmesis AT novaeskarynealbino regenerativecapacityandhistomorphometricchangesinratsciaticnervefollowingexperimentalneurotmesis AT demirandafilipebarbosacunha regenerativecapacityandhistomorphometricchangesinratsciaticnervefollowingexperimentalneurotmesis AT lirakamilladinahsantosde regenerativecapacityandhistomorphometricchangesinratsciaticnervefollowingexperimentalneurotmesis AT andraderodrigofragosode regenerativecapacityandhistomorphometricchangesinratsciaticnervefollowingexperimentalneurotmesis AT moraessilviareginaarrudade regenerativecapacityandhistomorphometricchangesinratsciaticnervefollowingexperimentalneurotmesis
_version_	1718444920807620608

Regenerative Capacity and Histomorphometric Changes in Rat Sciatic Nerve Following Experimental Neurotmesis

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