Phyllanthus emblica L. Branch Extract Ameliorates Testicular Damage in Valproic Acid-Induced Rats

Valproic acid (VPA), widely used in treating epileptic patients, can damage reproductive parameters causing male infertility. This study aimed to investigate protective effect of Phyllanthus emblica L. branch (PE) extract on rat testicular damage induced with VPA. Male rats were divided into 6 group...

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Autores principales:	Iamsaard,Sitthichai, Arun,Supatcharee, Burawat,Jaturon, Sukhorum,Wannisa, Boonruangsri,Porntip, Namking,Malivalaya, Uabundit,Nongnut, Nualkaew,Somsak, Sripanidkulchai,Bungorn
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2015
Materias:	Valproic acid Phyllanthus emblica L Testicular damage Rats
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000300033
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spelling	oai:scielo:S0717-950220150003000332015-12-04Phyllanthus emblica L. Branch Extract Ameliorates Testicular Damage in Valproic Acid-Induced RatsIamsaard,SitthichaiArun,SupatchareeBurawat,JaturonSukhorum,WannisaBoonruangsri,PorntipNamking,MalivalayaUabundit,NongnutNualkaew,SomsakSripanidkulchai,Bungorn Valproic acid Phyllanthus emblica L Testicular damage Rats Valproic acid (VPA), widely used in treating epileptic patients, can damage reproductive parameters causing male infertility. This study aimed to investigate protective effect of Phyllanthus emblica L. branch (PE) extract on rat testicular damage induced with VPA. Male rats were divided into 6 groups (control, VPA, 250 mg/kgBW PE only, and 50, 100, 250 mg/kgBW PE+VPA, respectively). Animals were pretreated with PE for 23 days and co-administered with VPA for 10 days before all reproductive parameters were determined. The results showed all doses of PE significantly protected the decrease testicular weight and testosterone level in VPA rats. PE significantly improved the decrease sperm concentration in VPA treated rats. Moreover, testicular histology of PE+VPA groups showed declining of testicular histopathologies as compared to VPA group. Therefore, it seems that PE branch extract can prevent testicular damages including male reproductive parameters in rats induced with VPA.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.33 n.3 20152015-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000300033en10.4067/S0717-95022015000300033
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Valproic acid Phyllanthus emblica L Testicular damage Rats
spellingShingle	Valproic acid Phyllanthus emblica L Testicular damage Rats Iamsaard,Sitthichai Arun,Supatcharee Burawat,Jaturon Sukhorum,Wannisa Boonruangsri,Porntip Namking,Malivalaya Uabundit,Nongnut Nualkaew,Somsak Sripanidkulchai,Bungorn Phyllanthus emblica L. Branch Extract Ameliorates Testicular Damage in Valproic Acid-Induced Rats
description	Valproic acid (VPA), widely used in treating epileptic patients, can damage reproductive parameters causing male infertility. This study aimed to investigate protective effect of Phyllanthus emblica L. branch (PE) extract on rat testicular damage induced with VPA. Male rats were divided into 6 groups (control, VPA, 250 mg/kgBW PE only, and 50, 100, 250 mg/kgBW PE+VPA, respectively). Animals were pretreated with PE for 23 days and co-administered with VPA for 10 days before all reproductive parameters were determined. The results showed all doses of PE significantly protected the decrease testicular weight and testosterone level in VPA rats. PE significantly improved the decrease sperm concentration in VPA treated rats. Moreover, testicular histology of PE+VPA groups showed declining of testicular histopathologies as compared to VPA group. Therefore, it seems that PE branch extract can prevent testicular damages including male reproductive parameters in rats induced with VPA.
author	Iamsaard,Sitthichai Arun,Supatcharee Burawat,Jaturon Sukhorum,Wannisa Boonruangsri,Porntip Namking,Malivalaya Uabundit,Nongnut Nualkaew,Somsak Sripanidkulchai,Bungorn
author_facet	Iamsaard,Sitthichai Arun,Supatcharee Burawat,Jaturon Sukhorum,Wannisa Boonruangsri,Porntip Namking,Malivalaya Uabundit,Nongnut Nualkaew,Somsak Sripanidkulchai,Bungorn
author_sort	Iamsaard,Sitthichai
title	Phyllanthus emblica L. Branch Extract Ameliorates Testicular Damage in Valproic Acid-Induced Rats
title_short	Phyllanthus emblica L. Branch Extract Ameliorates Testicular Damage in Valproic Acid-Induced Rats
title_full	Phyllanthus emblica L. Branch Extract Ameliorates Testicular Damage in Valproic Acid-Induced Rats
title_fullStr	Phyllanthus emblica L. Branch Extract Ameliorates Testicular Damage in Valproic Acid-Induced Rats
title_full_unstemmed	Phyllanthus emblica L. Branch Extract Ameliorates Testicular Damage in Valproic Acid-Induced Rats
title_sort	phyllanthus emblica l. branch extract ameliorates testicular damage in valproic acid-induced rats
publisher	Sociedad Chilena de Anatomía
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000300033
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Phyllanthus emblica L. Branch Extract Ameliorates Testicular Damage in Valproic Acid-Induced Rats

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