Effects of Nandrolone Decanoate on Spermatogenesis in Wistar Rats With and Without Physical Training

Androgenic anabolic steroids (AAS) are artificial testosterone analogues, used as medicine in chronic diseases, because they increase protein synthesis generating muscle hypertrophy. Its effect has caught the attention of athletes and gym users, thus their consumption has become epidemic, due to eas...

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Autores principales:	Maia,Bernardo Porto, Silveira,Jéssica de Oliveira, Borges,Mariana Garcia Lisboa, Pereira,Danilo Ales Ponzi, Pinheiro,Julyara Lima, Freitas,Jofre Jacob da Silva, Kietzer,Katia Simone
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2015
Materias:	Spermatogenesis Anabolic agents Nandrolone Exercise Fertility
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000300046
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spelling	oai:scielo:S0717-950220150003000462015-12-04Effects of Nandrolone Decanoate on Spermatogenesis in Wistar Rats With and Without Physical TrainingMaia,Bernardo PortoSilveira,Jéssica de OliveiraBorges,Mariana Garcia LisboaPereira,Danilo Ales PonziPinheiro,Julyara LimaFreitas,Jofre Jacob da SilvaKietzer,Katia Simone Spermatogenesis Anabolic agents Nandrolone Exercise Fertility Androgenic anabolic steroids (AAS) are artificial testosterone analogues, used as medicine in chronic diseases, because they increase protein synthesis generating muscle hypertrophy. Its effect has caught the attention of athletes and gym users, thus their consumption has become epidemic, due to easy marketing, the immediate results and the false impression that it doesn't carry health risks. Such risks may globally harm the body. This study aims to investigate the influence on spermatogenesis of using nandrolone decanoate with or without physical training. Twenty-four rats, divided into four groups were used: sedentary group (SG), sedentary on steroids group (SSG), trained group (TG) and trained on steroids group (TSG). The animals were trained on voluntary exercise wheel twice a week during 12 weeks, and were subsequently euthanized by decapitation. Groups TSG and SSG received intramuscular injections of 5 mg / kg of the AAS. It was found that there was a greater cellularity in TSG, suggesting interference between androgen therapy and physical training on the mount of cells in the seminiferous epithelium. Comparing the TSG group with the SG, it is noticed that the physical training associated with the use of steroid tends to affect cell division without compromise, however, the number of spermatogonia, did not significantly vary compared to the control group. Finally, it seems that there was no significant statistical difference among the groups in terms of spermatogenesis yield, so that can not be said that the use of nandrolone decanoate, with or without the physical training, interfere with fertility.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.33 n.3 20152015-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000300046en10.4067/S0717-95022015000300046
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Spermatogenesis Anabolic agents Nandrolone Exercise Fertility
spellingShingle	Spermatogenesis Anabolic agents Nandrolone Exercise Fertility Maia,Bernardo Porto Silveira,Jéssica de Oliveira Borges,Mariana Garcia Lisboa Pereira,Danilo Ales Ponzi Pinheiro,Julyara Lima Freitas,Jofre Jacob da Silva Kietzer,Katia Simone Effects of Nandrolone Decanoate on Spermatogenesis in Wistar Rats With and Without Physical Training
description	Androgenic anabolic steroids (AAS) are artificial testosterone analogues, used as medicine in chronic diseases, because they increase protein synthesis generating muscle hypertrophy. Its effect has caught the attention of athletes and gym users, thus their consumption has become epidemic, due to easy marketing, the immediate results and the false impression that it doesn't carry health risks. Such risks may globally harm the body. This study aims to investigate the influence on spermatogenesis of using nandrolone decanoate with or without physical training. Twenty-four rats, divided into four groups were used: sedentary group (SG), sedentary on steroids group (SSG), trained group (TG) and trained on steroids group (TSG). The animals were trained on voluntary exercise wheel twice a week during 12 weeks, and were subsequently euthanized by decapitation. Groups TSG and SSG received intramuscular injections of 5 mg / kg of the AAS. It was found that there was a greater cellularity in TSG, suggesting interference between androgen therapy and physical training on the mount of cells in the seminiferous epithelium. Comparing the TSG group with the SG, it is noticed that the physical training associated with the use of steroid tends to affect cell division without compromise, however, the number of spermatogonia, did not significantly vary compared to the control group. Finally, it seems that there was no significant statistical difference among the groups in terms of spermatogenesis yield, so that can not be said that the use of nandrolone decanoate, with or without the physical training, interfere with fertility.
author	Maia,Bernardo Porto Silveira,Jéssica de Oliveira Borges,Mariana Garcia Lisboa Pereira,Danilo Ales Ponzi Pinheiro,Julyara Lima Freitas,Jofre Jacob da Silva Kietzer,Katia Simone
author_facet	Maia,Bernardo Porto Silveira,Jéssica de Oliveira Borges,Mariana Garcia Lisboa Pereira,Danilo Ales Ponzi Pinheiro,Julyara Lima Freitas,Jofre Jacob da Silva Kietzer,Katia Simone
author_sort	Maia,Bernardo Porto
title	Effects of Nandrolone Decanoate on Spermatogenesis in Wistar Rats With and Without Physical Training
title_short	Effects of Nandrolone Decanoate on Spermatogenesis in Wistar Rats With and Without Physical Training
title_full	Effects of Nandrolone Decanoate on Spermatogenesis in Wistar Rats With and Without Physical Training
title_fullStr	Effects of Nandrolone Decanoate on Spermatogenesis in Wistar Rats With and Without Physical Training
title_full_unstemmed	Effects of Nandrolone Decanoate on Spermatogenesis in Wistar Rats With and Without Physical Training
title_sort	effects of nandrolone decanoate on spermatogenesis in wistar rats with and without physical training
publisher	Sociedad Chilena de Anatomía
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000300046
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Effects of Nandrolone Decanoate on Spermatogenesis in Wistar Rats With and Without Physical Training

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