Ultrastructure of Fetal Mice Hepatocytes Exposed in Utero to Diazepam

Previous research has shown that fetal mice hepatic cells from females treated with diazepam (Valium) during pregnancy depict cytoplasmic and nuclear modifications when observed with photonic microscope. The purpose of this work is to investigate if diazepam administered subcutaneously (SC) to pregn...

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Autores principales:	Márquez-Orozco,María Cristina, de la Fuente-Juárez,Graciela, Márquez-Orozco,Amalia
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2015
Materias:	Benzodiazepines Diazepam Fetal hepatocytes Ultrastructure
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000400040
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spelling	oai:scielo:S0717-950220150004000402016-03-22Ultrastructure of Fetal Mice Hepatocytes Exposed in Utero to DiazepamMárquez-Orozco,María Cristinade la Fuente-Juárez,GracielaMárquez-Orozco,Amalia Benzodiazepines Diazepam Fetal hepatocytes Ultrastructure Previous research has shown that fetal mice hepatic cells from females treated with diazepam (Valium) during pregnancy depict cytoplasmic and nuclear modifications when observed with photonic microscope. The purpose of this work is to investigate if diazepam administered subcutaneously (SC) to pregnant mice females induces ultraestructural alterations in the cytoplasmic organelles and nucleus to fetal hepatocytes. Transmission electron microscopy observations of fetal hepatocytes from pregnant females treated with a single daily dose of diazepam 2.7 mg/kg/bw/SC administered from 6th to 15th days of gestation revealed that they frequently presented disorganized and dilated rough endoplasmic reticulum cisterns, membranous elements, abundant Golgi complex and glycogen granules, around large vacuoles. The voluminous nucleus shows atypical distribution of chromatin. These alterations could modify the hepatocyte's physiology and probably persist after birth.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.33 n.4 20152015-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000400040en10.4067/S0717-95022015000400040
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Benzodiazepines Diazepam Fetal hepatocytes Ultrastructure
spellingShingle	Benzodiazepines Diazepam Fetal hepatocytes Ultrastructure Márquez-Orozco,María Cristina de la Fuente-Juárez,Graciela Márquez-Orozco,Amalia Ultrastructure of Fetal Mice Hepatocytes Exposed in Utero to Diazepam
description	Previous research has shown that fetal mice hepatic cells from females treated with diazepam (Valium) during pregnancy depict cytoplasmic and nuclear modifications when observed with photonic microscope. The purpose of this work is to investigate if diazepam administered subcutaneously (SC) to pregnant mice females induces ultraestructural alterations in the cytoplasmic organelles and nucleus to fetal hepatocytes. Transmission electron microscopy observations of fetal hepatocytes from pregnant females treated with a single daily dose of diazepam 2.7 mg/kg/bw/SC administered from 6th to 15th days of gestation revealed that they frequently presented disorganized and dilated rough endoplasmic reticulum cisterns, membranous elements, abundant Golgi complex and glycogen granules, around large vacuoles. The voluminous nucleus shows atypical distribution of chromatin. These alterations could modify the hepatocyte's physiology and probably persist after birth.
author	Márquez-Orozco,María Cristina de la Fuente-Juárez,Graciela Márquez-Orozco,Amalia
author_facet	Márquez-Orozco,María Cristina de la Fuente-Juárez,Graciela Márquez-Orozco,Amalia
author_sort	Márquez-Orozco,María Cristina
title	Ultrastructure of Fetal Mice Hepatocytes Exposed in Utero to Diazepam
title_short	Ultrastructure of Fetal Mice Hepatocytes Exposed in Utero to Diazepam
title_full	Ultrastructure of Fetal Mice Hepatocytes Exposed in Utero to Diazepam
title_fullStr	Ultrastructure of Fetal Mice Hepatocytes Exposed in Utero to Diazepam
title_full_unstemmed	Ultrastructure of Fetal Mice Hepatocytes Exposed in Utero to Diazepam
title_sort	ultrastructure of fetal mice hepatocytes exposed in utero to diazepam
publisher	Sociedad Chilena de Anatomía
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000400040
work_keys_str_mv	AT marquezorozcomariacristina ultrastructureoffetalmicehepatocytesexposedinuterotodiazepam AT delafuentejuarezgraciela ultrastructureoffetalmicehepatocytesexposedinuterotodiazepam AT marquezorozcoamalia ultrastructureoffetalmicehepatocytesexposedinuterotodiazepam
_version_	1718444940216762368

Ultrastructure of Fetal Mice Hepatocytes Exposed in Utero to Diazepam

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