Investigation of Various Events Occurring in the Brain Tissue After Calvarial Defects in Rats

Bone damage and accidents, traumas can alter people's normal life, and damage the soft tissues. In this study, we aimed to investigate in calvarial defects in rats depending on the severity of cerebral contusion injury occurring in the temporal region. The rats were randomly divided into two gr...

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Autores principales:	Tas,Mahmut, Gok,Ertugrul, Ekinci,Cenap, Deveci,Engin, Deveci,Senay
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2016
Materias:	Calvarial defects Rat Cerebrum Immunohistochemistry
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000100005
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spelling	oai:scielo:S0717-950220160001000052016-05-02Investigation of Various Events Occurring in the Brain Tissue After Calvarial Defects in RatsTas,MahmutGok,ErtugrulEkinci,CenapDeveci,EnginDeveci,Senay Calvarial defects Rat Cerebrum Immunohistochemistry Bone damage and accidents, traumas can alter people's normal life, and damage the soft tissues. In this study, we aimed to investigate in calvarial defects in rats depending on the severity of cerebral contusion injury occurring in the temporal region. The rats were randomly divided into two groups: group 1 (control group), critical size cranial model with no treatment (n= 10); group 2 (14-day synthetic graft group given 7th day DEXA), critical size cranial model treated with Dexamethasone (0.05 mg/kg intramuscular injection) +Synthetic graft (n= 10) One calvarium defect of 7 mm was made in the parietal bone of each animal under general anesthesia. Calvarial defect results in dilatation of blood vessels, hemorrhage and deterioration was observed in glial fibrillary structures. Additionally, the increase in vascular endothelial growth factor expression showed a positive reaction with glial fibrillary acid protein astrocytes extensions. Apoptotic glial cells stained positive with Bcl-2. Calvarial defects caused by mild brain injury, to be induced by inflammatory cytokines, interrupting glial fibrillary degeneration by affecting the blood brain barrier is thought to promote apoptotic changes.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.34 n.1 20162016-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000100005en10.4067/S0717-95022016000100005
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Calvarial defects Rat Cerebrum Immunohistochemistry
spellingShingle	Calvarial defects Rat Cerebrum Immunohistochemistry Tas,Mahmut Gok,Ertugrul Ekinci,Cenap Deveci,Engin Deveci,Senay Investigation of Various Events Occurring in the Brain Tissue After Calvarial Defects in Rats
description	Bone damage and accidents, traumas can alter people's normal life, and damage the soft tissues. In this study, we aimed to investigate in calvarial defects in rats depending on the severity of cerebral contusion injury occurring in the temporal region. The rats were randomly divided into two groups: group 1 (control group), critical size cranial model with no treatment (n= 10); group 2 (14-day synthetic graft group given 7th day DEXA), critical size cranial model treated with Dexamethasone (0.05 mg/kg intramuscular injection) +Synthetic graft (n= 10) One calvarium defect of 7 mm was made in the parietal bone of each animal under general anesthesia. Calvarial defect results in dilatation of blood vessels, hemorrhage and deterioration was observed in glial fibrillary structures. Additionally, the increase in vascular endothelial growth factor expression showed a positive reaction with glial fibrillary acid protein astrocytes extensions. Apoptotic glial cells stained positive with Bcl-2. Calvarial defects caused by mild brain injury, to be induced by inflammatory cytokines, interrupting glial fibrillary degeneration by affecting the blood brain barrier is thought to promote apoptotic changes.
author	Tas,Mahmut Gok,Ertugrul Ekinci,Cenap Deveci,Engin Deveci,Senay
author_facet	Tas,Mahmut Gok,Ertugrul Ekinci,Cenap Deveci,Engin Deveci,Senay
author_sort	Tas,Mahmut
title	Investigation of Various Events Occurring in the Brain Tissue After Calvarial Defects in Rats
title_short	Investigation of Various Events Occurring in the Brain Tissue After Calvarial Defects in Rats
title_full	Investigation of Various Events Occurring in the Brain Tissue After Calvarial Defects in Rats
title_fullStr	Investigation of Various Events Occurring in the Brain Tissue After Calvarial Defects in Rats
title_full_unstemmed	Investigation of Various Events Occurring in the Brain Tissue After Calvarial Defects in Rats
title_sort	investigation of various events occurring in the brain tissue after calvarial defects in rats
publisher	Sociedad Chilena de Anatomía
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000100005
work_keys_str_mv	AT tasmahmut investigationofvariouseventsoccurringinthebraintissueaftercalvarialdefectsinrats AT gokertugrul investigationofvariouseventsoccurringinthebraintissueaftercalvarialdefectsinrats AT ekincicenap investigationofvariouseventsoccurringinthebraintissueaftercalvarialdefectsinrats AT deveciengin investigationofvariouseventsoccurringinthebraintissueaftercalvarialdefectsinrats AT devecisenay investigationofvariouseventsoccurringinthebraintissueaftercalvarialdefectsinrats
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Investigation of Various Events Occurring in the Brain Tissue After Calvarial Defects in Rats

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