Maternal Malnutrition Diet During Lactation Period Leads to Incomplete Catch-Up Growth in Femur of the Pups at Adulthood

The aim of this study was to evaluate the effects of maternal protein and energy restriction during lactation, analyzing on morphological dimensions whether there was catch-up growth through normative nutrition restored, as well as on mechanical axis of femur of the offspring at adulthood. At partur...

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Autores principales: Babinski,Monique S. D, Ramos,Cristiane F, Fernandes,Rodrigo M. P, Cardoso,Gilberto P, Babinski,Marcio A
Lenguaje:English
Publicado: Sociedad Chilena de Anatomía 2016
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000100011
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spelling oai:scielo:S0717-950220160001000112016-05-02Maternal Malnutrition Diet During Lactation Period Leads to Incomplete Catch-Up Growth in Femur of the Pups at AdulthoodBabinski,Monique S. DRamos,Cristiane FFernandes,Rodrigo M. PCardoso,Gilberto PBabinski,Marcio A Rats Femur Undernutrition Growth Morphometry The aim of this study was to evaluate the effects of maternal protein and energy restriction during lactation, analyzing on morphological dimensions whether there was catch-up growth through normative nutrition restored, as well as on mechanical axis of femur of the offspring at adulthood. At parturition, Wistar rat dams were randomly assigned to the following groups: 1) control group (C) - free access to a standard laboratory diet containing 23 % protein, 2) protein-energy restricted group (PER) - free access to an isoenergetic, protein-restricted diet containing 8 % protein, and 3) energy-restricted group (ER) ­ fed with restricted amounts of a standard laboratory diet. At weaning, all pups were separated of dams and received free access to a standard laboratory diet containing 23 % protein until 180 days, when the rats were anesthetized and sacrificed. The dimensions of excised pup femur were measured directly using pre-established anatomical points. Morphometric analysis of the femur (macroscopic) showed that most of the measurements in the ER and PER groups were significantly lower than in the control group, with the greatest reductions occurring in the PER group and several structural abnormalities. Our results show that protein and energy restriction during lactation leads to an incomplete catch-up growth in adulthood. The femur showed significant reduction in most of the parameters in the two treated groups, particularly the PER group, when compared to the control group.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.34 n.1 20162016-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000100011en10.4067/S0717-95022016000100011
institution Scielo Chile
collection Scielo Chile
language English
topic Rats
Femur
Undernutrition
Growth
Morphometry
spellingShingle Rats
Femur
Undernutrition
Growth
Morphometry
Babinski,Monique S. D
Ramos,Cristiane F
Fernandes,Rodrigo M. P
Cardoso,Gilberto P
Babinski,Marcio A
Maternal Malnutrition Diet During Lactation Period Leads to Incomplete Catch-Up Growth in Femur of the Pups at Adulthood
description The aim of this study was to evaluate the effects of maternal protein and energy restriction during lactation, analyzing on morphological dimensions whether there was catch-up growth through normative nutrition restored, as well as on mechanical axis of femur of the offspring at adulthood. At parturition, Wistar rat dams were randomly assigned to the following groups: 1) control group (C) - free access to a standard laboratory diet containing 23 % protein, 2) protein-energy restricted group (PER) - free access to an isoenergetic, protein-restricted diet containing 8 % protein, and 3) energy-restricted group (ER) ­ fed with restricted amounts of a standard laboratory diet. At weaning, all pups were separated of dams and received free access to a standard laboratory diet containing 23 % protein until 180 days, when the rats were anesthetized and sacrificed. The dimensions of excised pup femur were measured directly using pre-established anatomical points. Morphometric analysis of the femur (macroscopic) showed that most of the measurements in the ER and PER groups were significantly lower than in the control group, with the greatest reductions occurring in the PER group and several structural abnormalities. Our results show that protein and energy restriction during lactation leads to an incomplete catch-up growth in adulthood. The femur showed significant reduction in most of the parameters in the two treated groups, particularly the PER group, when compared to the control group.
author Babinski,Monique S. D
Ramos,Cristiane F
Fernandes,Rodrigo M. P
Cardoso,Gilberto P
Babinski,Marcio A
author_facet Babinski,Monique S. D
Ramos,Cristiane F
Fernandes,Rodrigo M. P
Cardoso,Gilberto P
Babinski,Marcio A
author_sort Babinski,Monique S. D
title Maternal Malnutrition Diet During Lactation Period Leads to Incomplete Catch-Up Growth in Femur of the Pups at Adulthood
title_short Maternal Malnutrition Diet During Lactation Period Leads to Incomplete Catch-Up Growth in Femur of the Pups at Adulthood
title_full Maternal Malnutrition Diet During Lactation Period Leads to Incomplete Catch-Up Growth in Femur of the Pups at Adulthood
title_fullStr Maternal Malnutrition Diet During Lactation Period Leads to Incomplete Catch-Up Growth in Femur of the Pups at Adulthood
title_full_unstemmed Maternal Malnutrition Diet During Lactation Period Leads to Incomplete Catch-Up Growth in Femur of the Pups at Adulthood
title_sort maternal malnutrition diet during lactation period leads to incomplete catch-up growth in femur of the pups at adulthood
publisher Sociedad Chilena de Anatomía
publishDate 2016
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000100011
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