Effects of Polymeric Zinc Propylen-Bis-Dithiocarbamate (Propineb) on Nasal Mucosa in Rats

The objective of this study was to evaluate the histopathologic and immunohistochemical effects of propineb on rat nasal mucosa. Twenty adult Sprague-Dawley rats weighing 180220 g, were used as experimental animals. The rats were divided into propineb and control groups. The control group received...

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Autores principales:	Samanci,Baver, Arslan,Eda, Samanci,Seyla Bolukbasi, Caypinar,Basak, Deveci,Engin, Söker,Sevda, Seker,Ugur
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2016
Materias:	Propineb Nasal mucosa Proliferating Cell Nuclear Antigen (PCNA) CD34
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000100013
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spelling	oai:scielo:S0717-950220160001000132016-05-02Effects of Polymeric Zinc Propylen-Bis-Dithiocarbamate (Propineb) on Nasal Mucosa in RatsSamanci,BaverArslan,EdaSamanci,Seyla BolukbasiCaypinar,BasakDeveci,EnginSöker,SevdaSeker,Ugur Propineb Nasal mucosa Proliferating Cell Nuclear Antigen (PCNA) CD34 The objective of this study was to evaluate the histopathologic and immunohistochemical effects of propineb on rat nasal mucosa. Twenty adult Sprague-Dawley rats weighing 180220 g, were used as experimental animals. The rats were divided into propineb and control groups. The control group received distilled water with spray at the same time period. The experiment was terminated after three weeks. In each case, sections of the nosewere taken. In experimental group, microscopic examination of nasal respiratory mucosa revealed that degenerative changes in epithelium were observed in sections of propineb-treated group. There were also leukocyte infiltration and vascular dilatation detected in the connective tissue.We detected CD34-immunoreactive mononuclear cells and endothel cells in the lamina propria of propineb group. In propineb group compared to the control group, the respiratory epithelium, goblet and basal cell nuclei were stained positive for PCNA. Propineb inhalation may be irritating to the nasal mucosa.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.34 n.1 20162016-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000100013en10.4067/S0717-95022016000100013
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Propineb Nasal mucosa Proliferating Cell Nuclear Antigen (PCNA) CD34
spellingShingle	Propineb Nasal mucosa Proliferating Cell Nuclear Antigen (PCNA) CD34 Samanci,Baver Arslan,Eda Samanci,Seyla Bolukbasi Caypinar,Basak Deveci,Engin Söker,Sevda Seker,Ugur Effects of Polymeric Zinc Propylen-Bis-Dithiocarbamate (Propineb) on Nasal Mucosa in Rats
description	The objective of this study was to evaluate the histopathologic and immunohistochemical effects of propineb on rat nasal mucosa. Twenty adult Sprague-Dawley rats weighing 180220 g, were used as experimental animals. The rats were divided into propineb and control groups. The control group received distilled water with spray at the same time period. The experiment was terminated after three weeks. In each case, sections of the nosewere taken. In experimental group, microscopic examination of nasal respiratory mucosa revealed that degenerative changes in epithelium were observed in sections of propineb-treated group. There were also leukocyte infiltration and vascular dilatation detected in the connective tissue.We detected CD34-immunoreactive mononuclear cells and endothel cells in the lamina propria of propineb group. In propineb group compared to the control group, the respiratory epithelium, goblet and basal cell nuclei were stained positive for PCNA. Propineb inhalation may be irritating to the nasal mucosa.
author	Samanci,Baver Arslan,Eda Samanci,Seyla Bolukbasi Caypinar,Basak Deveci,Engin Söker,Sevda Seker,Ugur
author_facet	Samanci,Baver Arslan,Eda Samanci,Seyla Bolukbasi Caypinar,Basak Deveci,Engin Söker,Sevda Seker,Ugur
author_sort	Samanci,Baver
title	Effects of Polymeric Zinc Propylen-Bis-Dithiocarbamate (Propineb) on Nasal Mucosa in Rats
title_short	Effects of Polymeric Zinc Propylen-Bis-Dithiocarbamate (Propineb) on Nasal Mucosa in Rats
title_full	Effects of Polymeric Zinc Propylen-Bis-Dithiocarbamate (Propineb) on Nasal Mucosa in Rats
title_fullStr	Effects of Polymeric Zinc Propylen-Bis-Dithiocarbamate (Propineb) on Nasal Mucosa in Rats
title_full_unstemmed	Effects of Polymeric Zinc Propylen-Bis-Dithiocarbamate (Propineb) on Nasal Mucosa in Rats
title_sort	effects of polymeric zinc propylen-bis-dithiocarbamate (propineb) on nasal mucosa in rats
publisher	Sociedad Chilena de Anatomía
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000100013
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Effects of Polymeric Zinc Propylen-Bis-Dithiocarbamate (Propineb) on Nasal Mucosa in Rats

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