Evaluation of Placental Epigenetic Changes due to Morphine Consumption

Based on previous studies, a variety of bioenvironmental elements including inappropriate nutrition, diseases, infections, stressors, and medications are involved in epigenetic changes. Drug abuse is one of the most important causes of epigenetic changes and a concern in today's world. Studies...

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Autores principales:	Kazemi,Masoomeh, Tekieh,Elaheh, Golabi,Sahar, Sahraei,Hedayat
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2016
Materias:	Development Morphine Embryo Epigenetic Pregnancy Placenta
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000100036
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spelling	oai:scielo:S0717-950220160001000362016-05-02Evaluation of Placental Epigenetic Changes due to Morphine ConsumptionKazemi,MasoomehTekieh,ElahehGolabi,SaharSahraei,Hedayat Development Morphine Embryo Epigenetic Pregnancy Placenta Based on previous studies, a variety of bioenvironmental elements including inappropriate nutrition, diseases, infections, stressors, and medications are involved in epigenetic changes. Drug abuse is one of the most important causes of epigenetic changes and a concern in today's world. Studies have shown that morphine use by pregnant mothers causes several disorders in mothers in addition to transferring abnormalities to the next generation (placenta and embryo). Epigenetic factors such as morphine cause changes in gene expression in placenta as the first embryonic defense barrier. Because placenta does all the nutritional exchanges between mother's and embryo's blood, placental health guarantees normal embryonic development. Many studies have been conducted on defects caused by epigenetic factors including medication use. Opioid abuse including morphine abuse has endangered health of many people. Morphine changes gene expression by binding to opioid receptors on placental villi. Based on the studies, major epigenetic changes due to drug use are mediated by DNA methylation and histone changes. Recognizing different epigenetic factors and their effect on placental and embryonic development is among modern studies. The importance of recognizing epigenetic changes caused by drug abuse by pregnant mothers can be the most important way to prevent adulthood diseases in the embryo and in some cases miscarriage. Changes induced by epigenetic factors can be moderated or reversed by controlling the epigenetic factors. This study is a review of changes caused by morphine use by pregnant rats on development of placenta.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.34 n.1 20162016-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000100036en10.4067/S0717-95022016000100036
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Development Morphine Embryo Epigenetic Pregnancy Placenta
spellingShingle	Development Morphine Embryo Epigenetic Pregnancy Placenta Kazemi,Masoomeh Tekieh,Elaheh Golabi,Sahar Sahraei,Hedayat Evaluation of Placental Epigenetic Changes due to Morphine Consumption
description	Based on previous studies, a variety of bioenvironmental elements including inappropriate nutrition, diseases, infections, stressors, and medications are involved in epigenetic changes. Drug abuse is one of the most important causes of epigenetic changes and a concern in today's world. Studies have shown that morphine use by pregnant mothers causes several disorders in mothers in addition to transferring abnormalities to the next generation (placenta and embryo). Epigenetic factors such as morphine cause changes in gene expression in placenta as the first embryonic defense barrier. Because placenta does all the nutritional exchanges between mother's and embryo's blood, placental health guarantees normal embryonic development. Many studies have been conducted on defects caused by epigenetic factors including medication use. Opioid abuse including morphine abuse has endangered health of many people. Morphine changes gene expression by binding to opioid receptors on placental villi. Based on the studies, major epigenetic changes due to drug use are mediated by DNA methylation and histone changes. Recognizing different epigenetic factors and their effect on placental and embryonic development is among modern studies. The importance of recognizing epigenetic changes caused by drug abuse by pregnant mothers can be the most important way to prevent adulthood diseases in the embryo and in some cases miscarriage. Changes induced by epigenetic factors can be moderated or reversed by controlling the epigenetic factors. This study is a review of changes caused by morphine use by pregnant rats on development of placenta.
author	Kazemi,Masoomeh Tekieh,Elaheh Golabi,Sahar Sahraei,Hedayat
author_facet	Kazemi,Masoomeh Tekieh,Elaheh Golabi,Sahar Sahraei,Hedayat
author_sort	Kazemi,Masoomeh
title	Evaluation of Placental Epigenetic Changes due to Morphine Consumption
title_short	Evaluation of Placental Epigenetic Changes due to Morphine Consumption
title_full	Evaluation of Placental Epigenetic Changes due to Morphine Consumption
title_fullStr	Evaluation of Placental Epigenetic Changes due to Morphine Consumption
title_full_unstemmed	Evaluation of Placental Epigenetic Changes due to Morphine Consumption
title_sort	evaluation of placental epigenetic changes due to morphine consumption
publisher	Sociedad Chilena de Anatomía
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000100036
work_keys_str_mv	AT kazemimasoomeh evaluationofplacentalepigeneticchangesduetomorphineconsumption AT tekiehelaheh evaluationofplacentalepigeneticchangesduetomorphineconsumption AT golabisahar evaluationofplacentalepigeneticchangesduetomorphineconsumption AT sahraeihedayat evaluationofplacentalepigeneticchangesduetomorphineconsumption
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Evaluation of Placental Epigenetic Changes due to Morphine Consumption

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